Biocontainment of genetically modified organisms by synthetic protein design

Nature

Volumn 518, Issue 7537, 2015, Pages 55-60

  Mandell, Daniel J ^a   Lajoie, Marc J ^a,b   Mee, Michael T ^a,c   Takeuchi, Ryo ^d   Kuznetsov, Gleb ^a   Norville, Julie E ^a   Gregg, Christopher J ^a   Stoddard, Barry L ^d   Church, George M ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Boston University   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ESCHERICHIA COLI PROTEIN; CODON;

AMINO ACID; ENZYME ACTIVITY; EVOLUTIONARY BIOLOGY; GENE TRANSFER; GENETICALLY MODIFIED ORGANISM; MUTAGENICITY; PROTEIN;

ARTICLE; AUXOTROPHY; BACTERIAL METABOLISM; BACTERIAL SURVIVAL; BACTERIUM ISOLATION; ECOSYSTEM; ENZYME STRUCTURE; ESCHERICHIA COLI; ESCHERICHIA COLI C321; GENETIC CODE; HORIZONTAL GENE TRANSFER; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSGENIC ORGANISM; BIOSYNTHESIS; CHEMISTRY; CODON; ENZYMOLOGY; ESSENTIAL GENE; EVOLUTION; GENETIC ENGINEERING; GENETIC SELECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAZARDOUS WASTE; METABOLISM; MICROBIAL VIABILITY; MUTATION; PROCEDURES; SAFETY; SYNTHETIC BIOLOGY;

ESCHERICHIA COLI;

AMINO ACIDS; BIOLOGICAL EVOLUTION; CODON; CONTAINMENT OF BIOHAZARDS; ECOSYSTEM; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE TRANSFER, HORIZONTAL; GENES, ESSENTIAL; GENETIC CODE; GENETIC ENGINEERING; MICROBIAL VIABILITY; MUTATION; ORGANISMS, GENETICALLY MODIFIED; SAFETY; SELECTION, GENETIC; SYNTHETIC BIOLOGY;

EID: 84923112573     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14121     Document Type: Article

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