Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

British Journal of Haematology

Volumn 168, Issue 4, 2015, Pages 553-556

  van der Land, Veronica ^a   Hijmans, Channa T ^a   de Ruiter, Marieke ^a   Mutsaerts, Henri J M M ^b   Cnossen, Marjon H ^c   Engelen, Marc ^a   Majoie, Charles B L M ^b   Nederveen, Aart J ^b   Grootenhuis, Martha A ^a   Fijnvandraat, Karin ^a  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Neurocognitive functioning; Sickle cell disease; Silent cerebral infarcts

Indexed keywords

ADOLESCENT; ARTICLE; ASSESSMENT OF HUMANS; BEHAVIOUR RATING INVENTORY OF EXECUTIVE FUNCTION METACOGNITION INDEX; BEHAVIOUR RATING INVENTORY OF EXECUTIVE FUNCTION TOTAL SCORE; BRAIN SIZE; CHILD; CLINICAL ARTICLE; COGNITION ASSESSMENT; COGNITIVE FATIGUE SUBSCALE; EXECUTIVE FUNCTION; FATIGUE; FATIGUE TOTAL SCORE; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MALE; NERVOUS SYSTEM PARAMETERS; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; PREDICTOR VARIABLE; PROSPECTIVE STUDY; SICKLE CELL ANEMIA; WHITE MATTER; WHITE MATTER HYPERINTENSITY; BRAIN; CEREBRAL INFARCTION; COGNITION DISORDERS; COMPLICATION; INTELLIGENCE; INTELLIGENCE TEST; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGY; THINKING;

ADOLESCENT; ANEMIA, SICKLE CELL; BRAIN; CEREBRAL INFARCTION; CHILD; COGNITION DISORDERS; FATIGUE; FEMALE; HUMANS; INTELLIGENCE; INTELLIGENCE TESTS; MAGNETIC RESONANCE IMAGING; MALE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; THINKING; WHITE MATTER;

EID: 84923107854     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13179     Document Type: Article

References (15)

1. Bender, R. & Lange, S. (2001) Adjusting for multiple testing-when and how? Journal of Clinical Epidemiology, 54, 343-349.
2. Bernaudin, F., Verlhac, S., Freard, F., Roudot-Thoraval, F., Benkerrou, M., Thuret, I., Mardini, R., Vannier, J.P., Ploix, E., Romero, M., Casse-Perrot, C., Helly, M., Gillard, E., Sebag, G., Kchouk, H., Pracros, J.P., Finck, B., Dacher, J.N., Ickowicz, V., Raybaud, C., Poncet, M., Lesprit, E., Reinert, P.H. & Brugieres, P. (2000) Multicenter prospective study of children with sickle cell disease: radiographic and psychometric correlation. Journal of Child Neurology, 15, 333-343.
3. Bernaudin, F., Verlhac, S., Arnaud, C., Kamdem, A., Chevret, S., Hau, I., Coïc, L., Leveillé, E., Lemarchand, E., Lesprit, E., Abadie, I., Medejel, N., Madhi, F., Lemerle, S., Biscardi, S., Bardakdjian, J., Galactéros, F., Torres, M., Kuentz, M., Ferry, C., Socié, G., Reinert, P. & Delacourt, C. (2011) Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort. Blood, 117, 1130-1140.
4. Birdsill, A.C., Koscik, R.L., Jonaitis, E.M., Johnson, S.C., Okonkwo, O.C., Hermann, B.P., LaRue, A., Sager, M.A. & Bendlin, B.B. (2014) Regional white matter hyperintensities: Aging, Alzheimer's disease risk, and cognitive function. Neurobiology of Aging, 35, 769-776.
5. DeBaun, M.R., Gordon, M., McKinstry, R.C., Noetzel, M.J., White, D.A., Sarnaik, S.A., Meier, E.R., Howard, T.H., Majumdar, S., Inusa, B.P.D., Telfer, P.T., Kirby-Allen, M., McCavit, T.L., Kamdem, A., Airewele, G., Woods, G.M., Berman, B., Panepinto, J.A., Fuh, B.R., Kwiatkowski, J.L., King, A.A., Fixler, J.M., Rhodes, M.M., Thompson, A.A., Heiny, M.E., Redding-Lallinger, R.C., Kirkham, F.J., Dixon, N., Gonzalez, C.E., Kalinyak, K.A., Quinn, C.T., Strouse, J.J., Miller, J.P., Lehmann, H., Kraut, M.A., Ball, W.S., Hirtz, D. & Casella, J.F. (2014) Controlled Trial of Transfusions for Silent Cerebral Infarcts in Sickle Cell Anemia. The New England Journal of Medicine, 371, 699-710.
6. Hijmans, C.T., Grootenhuis, M.A., Oosterlaan, J., Heijboer, H., Peters, M. & Fijnvandraat, K. (2010) Neurocognitive deficits in children with sickle cell disease are associated with the severity of anemia. Pediatric Blood & Cancer, 56, 783-788.
7. Kochunov, P., Coyle, T., Lancaster, J., Robin, D.A., Hardies, J., Kochunov, V., Bartzokis, G., Stanley, J., Royall, D., Schlosser, A.E., Null, M. & Fox, P.T. (2010) Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging. NeuroImage, 49, 1190-1199.
8. Kwiatkowski, J.L., Zimmerman, R.A., Pollock, A.N., Seto, W., Smith-Whitley, K., Shults, J., Blackwood-Chirchir, A. & Ohene-Fremping, K. (2009) Silent infarcts in young children with sickle cell disease. British Journal of Haematology, 146, 300-305.
9. Mackin, R.S., Insel, P., Truran, D., Vichinsky, E.P., Neumayr, L.D., Armstrong, F.D., Gold, J.I., Kesler, K., Brewer, J. & Weiner, M.W. (2014) Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition. Neurology, 82, 835-841.
10. Moser, F.G., Miller, S.T., Bello, J.A., Pegelow, C.H., Zimmerman, R.A., Wang, W.C., Ohene-frempong, K., Schwartz, A., Vichinsky, E.P., Gallagher, D. & Kinney, T.R. (1995) The spectrum of brain MR abnormalities in sickle-cell disease : a report from the Cooperative Study of Sickle Cell Disease. American Journal of Neuroradiology, 17, 965-972.
11. Schatz, J., White, D.A., Moinuddin, A., Armstrong, M. & DeBaun, M.R. (2002) Lesion burden and cognitive morbidity in children with sickle cell disease. Journal of Child Neurology, 17, 890-894.
12. Smith, E.E., Salat, D.H., Jeng, J., McCreary, C.R., Fischl, B., Schmahmann, J.D., Dickerson, B.C., Viswanathan, A., Albert, M.S., Blacker, D. & Greenberg, S.M. (2011) Correlations between MRI white matter lesion location and executive function and episodic memory. Neurology, 76, 1492-1499.
13. Steen, R.G., Miles, M.A., Helton, K.J., Strawn, S., Wang, W., Xiong, X. & Mulhern, R.K. (2003) Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit. American Journal of Neuroradiology, 24, 382-389.
14. Vichinsky, E.P., Neumayr, L.D., Gold, J.I., Weiner, M.W. & Rule, R.R. (2010) Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. Journal of the American Medical Association, 303, 1823-1831.
15. Wang, W., Enos, L., Gallagher, D., Thompson, R., Guarini, L., Vichinsky, E., Wright, E., Zimmerman, R. & Armstrong, F.D. (2001) Neuropsychologic performance in school-aged children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. The Journal of pediatrics, 139, 391-397.