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Bioorganic and Medicinal Chemistry

Volumn 23, Issue 5, 2015, Pages 1157-1168

Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists

(8) Hu, Suwen a Wang, Zhilong b Hou, Tingjun a,c Ma, Xiaodong a Li, Jing b Liu, Tao a Xie, Xin b Hu, Yongzhou a

a ZHEJIANG UNIVERSITY (China)

b INSTITUTE OF GEOLOGY AND GEOPHYSICS (China)

c SOOCHOW UNIVERSITY (China)

Author keywords

2 Methylpiperazine derivatives; Anti HIV 1 agent; CCR5 antagonist

Indexed keywords

1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [2 METHYL 4 (4 METHYLBENZYL)PIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (2 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 CYANOBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZOYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL) 1,4 DIAZEPAN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL] 1 (METHYLSULFONYL)PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 3 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROPHENYLSULFONYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLORO 4 METHYLPHENYL) N [3 [5 (4 FLUOROBENZYL) 2 ,5 DIAZABICYCLO[2.2.1]HEPTAN 2 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N (3 CHLOROPHENYL) N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N [3 (4 BENZYL 2 METHYLPIPERAZIN 1 YL)PROPYL] N (3 CHLORO 4 METHYLPHENYL)PIPERIDINE 4 CARBOXAMIDE; 1 ACETYL N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL] N PHENYLPIPERIDINE 4 CARBOXAMIDE; 1 BENZOYL N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]PIPERIDINE 4 CARBOXAMIDE; 2 METHYLPIPERAZINE DERIVATIVE; ANTIVIRUS AGENT; CALCIUM; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; MARAVIROC; N (3 CHLORO 4 METHYLPHENYL) 4 FLUORO N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]BENZAMIDE; N (3 CHLORO 4 METHYLPHENYL) N [3 [4 (4 FLUOROBENZYL) 2 METHYLPIPERAZIN 1 YL]PROPYL]ACETAMIDE; UNCLASSIFIED DRUG; 2-METHYLPIPERAZINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CCR5 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR5; PIPERAZINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CALCIUM MOBILIZATION ASSAY; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; VIRUS IDENTIFICATION; VIRUS INFECTIVITY; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; HAMSTER; HUMAN; PATHOGENICITY; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; ANTI-HIV AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; HIV-1; HUMANS; PIPERAZINES; RECEPTORS, CCR5;

EID: 84923083716 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.12.052 Document Type: Article

Times cited : (13)

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