Revisiting mendelian randomization studies of the effect of body mass index on depression

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 168, Issue 2, 2015, Pages 108-115

  Walter, Stefan ^a,b   Kubzansky, Laura D ^a   Koenen, Karestan C ^c   Liang, Liming ^a   Tchetgen Tchetgen, Eric J ^a   Cornelis, Marilyn C ^a   Chang, Shun Chiao ^a   Rimm, Eric ^a   Kawachi, Ichiro ^a   Glymour, M Maria ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Colombia University ^*  (United States)

Author keywords

Adiposity; Causation; FTO; Genetic; Instrumental variable analysis; Obesity

Indexed keywords

MELANOCORTIN 4 RECEPTOR;

ADULT; AGE DISTRIBUTION; ALLELE; ARTICLE; BODY MASS; DEPRESSION; DEPRESSION ASSESSMENT; FAT MASS; FEMALE; GENETIC ANALYSIS; GERIATRIC DEPRESSION SCALE; HUMAN; MAJOR CLINICAL STUDY; MENDELIAN RANDOMIZATION ANALYSIS; MENTAL HEALTH; MIDDLE AGED; PRIORITY JOURNAL; QUASI EXPERIMENTAL STUDY; RISK ASSESSMENT; SELF REPORT; VALIDITY; BIOLOGICAL MODEL; GENETICS; GENOTYPE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BODY MASS INDEX; DEPRESSION; FEMALE; GENOTYPE; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84923070179     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32286     Document Type: Article

References (24)

1. Angrist JD, Krueger AB. 1994. Split Sample Instrumental Variables. National Bureau of Economic Research Technical Paper 150.
2. Angrist JD, Krueger AB. 1995. Split-Sample Instrumental Variables Estimates of the Return to Schooling. J Bus Econ Stat 13 (2):225-235.
3. Brundtland GH. 2001. From the World Health Organization. Mental health: New understanding, new hope. JAMA 286(19):2391.
4. Colditz GA, Hankinson SE. 2005. The Nurses' Health Study: Lifestyle and health among women. Nat Rev Cancer 5(5):388-396.
5. Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE. 2011. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 7(4):e1002033.
6. Chang S-C, Glymour MM, Walter S, Liang L, Koenen KC, Tchetgen EJ, Cornelis MC, Kawachi I, Rimm E, Kubzansky LD. 2014. Genome-wide polygenic scoring for a 14-year long-term average depression phenotype. Brain Behav 4(2):298-311.
7. Davey Smith, Ebrahim G. 2003. 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?. Int J Epidemiol 32(1):1-22.
8. Glymour MM, Tchetgen EJ, Robins JM. 2012. Credible Mendelian randomization studies: Approaches for evaluating the instrumental variable assumptions. Am J Epidemiol 175(4):332-339.
9. Jokela M, Elovainio M, Keltikangas-Jarvinen L, Batty GD, Hintsanen M, Seppala I, Kahonen M, Viikari JS, Raitakari OT, Lehtimaki T, Kivimaki M. 2012. Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score. Genes Brain Behav 11 (8):942-948.
10. Kivimäki M, Jokela M, Hamer M, Geddes J, Ebmeier K, Kumari M, Singh-Manoux A, Hingorani A, Batty GD. 2011. Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-sssociated (FTO) genotype-instrumented analysis. Am J Epidemiol 173(4):421-429.
11. Lawlor DA, Harbord RM, Tybjaerg Hansen, Palmer A, Zacho TM, Benn J, Timpson M, Davey NJ, Smith G, Nordestgaard BG. 2011. Using genetic loci to understand the relationship between adiposity and psychological distress: A mendelian randomization study in the copenhagen general population study of 53 221 adults. J Intern Med 269(5):525-537.
12. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. 2010. Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67(3):220-229.
13. Meyers AW, Klesges RC, Winders SE, Ward KD, Peterson BA, Eck LH. 1997. Are weight concerns predictive of smoking cessation? A prospective analysis. J Consult Clin Psychol 65(3):448-452.
14. Monsees GM, Tamimi RM, Kraft P. 2009. Genome-wide association scans for secondary traits using case-control samples. Genet Epidemiol 33(8):717-728.
15. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38(8):904-909.
16. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P, Ruderfer DM, McQuillin A, Morris DW. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256):748-752.
17. Richmond RC, Davey Smith, Ness G, den Hoed AR, McMahon M, Timpson G. 2014. Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. PLoS Med 11(3):e1001618.
18. Rimm EB, Stampfer MJ, Colditz GA, Chute CG, Litin LB, Willett WC. 1990. Validity of self-reported waist and hip circumferences in men and women. Epidemiology 1(6):466-473.
19. Samaan Z, Anand S, Zhang X, Desai D, Rivera M, Pare G, Thabane L, Xie C, Gerstein H, Engert JC, Craig I, Cohen-Woods S, Mohan V, Diaz R, Wang X, Liu L, Corre T, Preisig M, Kutalik Z, Bergmann S, Vollenweider P, Waeber G, Yusuf S, Meyre D. 2013. The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. Mol Psychiatry 18, 1281-1286.
20. Sharp LK, Lipsky MS. 2002. Screening for depression across the lifespan: A review of measures for use in primary care settings. Am Fam Physician 66(6):1001-1008.
21. Sheikh JI YJ. 1986. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. In: Brink TL e, editor. Clinical Gerontology: A Guide to Assessment and Intervention. New York: The Haworth Press. p 165-173.
22. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R. 2010. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42(11):937-948.
23. Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB, Furberg H, Sullivan PF, Marchini J, McCarthy MI, Steinthorsdottir V, Thorsteinsdottir U, Stefansson K. 2013. A common biological basis of obesity and nicotine addiction. Transl Psychiatry 3:e308.
24. Volkow ND, Wang GJ, Fowler JS, Telang F. 2008. Overlapping neuronal circuits in addiction and obesity: Evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci 363(1507):3191-3200.