Age, sex, and racial influences on the Beckman Coulter AccuTnI+3 99th percentile

Clinica Chimica Acta

Volumn 444, Issue , 2015, Pages 149-153

  Greene, Dina N ^a   Leong, Thomas K ^a   Collinson, Paul O ^b   Kamer, Sandy M ^a   Huang, Karl ^a   Lorey, Thomas S ^a   Go, Alan S ^a,c,d  

^a KAISER PERMANENTE   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

99th percentile; AccuTnI+3; Beckman access; CTnI; False positive; Troponin

Indexed keywords

HETEROPHILE ANTIBODY; TROPONIN I;

ADULT; AGE; AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC KIT; FALSE POSITIVE RESULT; FEMALE; HUMAN; MALE; MIDDLE AGED; NORMAL HUMAN; PATIENT SELECTION; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RACE; SEX DIFFERENCE; UNITED STATES; VERY ELDERLY; ADOLESCENT; AGING; ANCESTRY GROUP; BIOASSAY; BLOOD; LABORATORY TEST; SENSITIVITY AND SPECIFICITY; SEXUAL DEVELOPMENT; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BIOLOGICAL ASSAY; CLINICAL LABORATORY TECHNIQUES; CONTINENTAL POPULATION GROUPS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SEX CHARACTERISTICS; TROPONIN I; YOUNG ADULT;

EID: 84923049837     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2015.02.005     Document Type: Article

References (29)

1. Thygesen K., Alpert J.S., Jaffe A.S., Simoons M.L., Chaitman B.R., White H.D., et al. Third universal definition of myocardial infarction. Circulation 2012, 126:2020-2035.
2. Sandoval Y., Apple F.S. The global need to define normality: the 99th percentile value of cardiac troponin. Clin Chem 2014, 60:455-462.
3. Collinson P.O., Heung Y.M., Gaze D., Boa F., Senior R., Christenson R., et al. Influence of population selection on the 99th percentile reference value for cardiac troponin assays. Clin Chem 2012, 58:219-225.
4. Eggers K.M., Jaffe A.S., Lind L., Venge P., Lindahl B. Value of cardiac troponin i cutoff concentrations below the 99th percentile for clinical decision-making. Clin Chem 2009, 55:85-92.
5. Eggers K.M., Lind L., Venge P., Lindahl B. Factors influencing the 99th percentile of cardiac troponin i evaluated in community-dwelling individuals at 70 and 75years of age. Clin Chem 2013, 59:1068-1073.
6. Koerbin G., Abhayaratna W.P., Potter J.M., Apple F.S., Jaffe A.S., Ravalico T.H., et al. Effect of population selection on 99th percentile values for a high sensitivity cardiac troponin i and t assays. Clin Biochem 2013, 46:1636-1643.
7. McKie P.M., Heublein D.M., Scott C.G., Gantzer M.L., Mehta R.A., Rodeheffer R.J., et al. Defining high-sensitivity cardiac troponin concentrations in the community. Clin Chem 2013, 59:1099-1107.
8. Gore M.O., Seliger S.L., Defilippi C.R., Nambi V., Christenson R.H., Hashim I.A., et al. Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin t assay. J Am Coll Cardiol 2014, 63:1441-1448.
9. Cardinaels E.P., Mingels A.M., Jacobs L.H., Meex S.J., Bekers O., van Dieijen-Visser M.P. A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead. Clin Chem Lab Med 2012, 50:791-806.
10. Krintus M., Kozinski M., Boudry P., Capell N.E., Koller U., Lackner K., et al. European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay. Clin Chem Lab Med 2014, 11:1657-1665.
11. Apple F.S., Ler R., Murakami M.M. Determination of 19 cardiac troponin i and t assay 99th percentile values from a common presumably healthy population. Clin Chem 2012, 58:1574-1581.
12. Franzini M., Lorenzoni V., Masotti S., Prontera C., Chiappino D., Latta D.D., et al. The calculation of the cardiac troponin t 99th percentile of the reference population is affected by age, gender, and population selection: a multicenter study in Italy. Clin Chim Acta 2015, 438:376-381.
13. Gaggin H.K., Dang P.V., Do L.D., deFilippi C.R., Christenson R.H., Lewandrowski E.L., et al. Reference interval evaluation of high-sensitivity troponin t and n-terminal b-type natriuretic peptide in Vietnam and the US: the North South East West Trial. Clin Chem 2014, 60:758-764.
14. BC Inc. AccuTnI+3 [Vol., Accessed July 2014]. https://www.Beckmancoulter.Com/wsrportal/bibliography?Docname=ds-18114_accutni+3_access_2_us.Pdf.
15. Storrow A.B., Christenson R.H., Nowak R.M., Diercks D.B., Singer A.J., Wu A.H., et al. Diagnostic performance of cardiac troponin i for early rule-in and rule-out of acute myocardial infarction: results of a prospective multicenter trial. Clin Biochem 2014, (epub ahead of print).
16. Levey A.S., Stevens L.A., Schmid C.H., Zhang Y.L., Castro A.F., Feldman H.I., et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009, 150:604-612.
17. Greene D.N., Holmes D.T., Liang J., Kwong S.L., Lorey T.S., Petrie M.S. Challenges in harmonizing integrated healthcare network laboratories: multi-center evaluation of the AccuTnI+3 troponin assay. Clin Biochem 2014, (epub ahead of print).
18. Hildebrandt P., Collinson P.O., Doughty R.N., Fuat A., Gaze D.C., Gustafsson F., et al. Age-dependent values of n-terminal pro-b-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. Eur Heart J 2010, 31:1881-1889.
19. Clerico A., Giannoni A., Vittorini S., Passino C. Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones. Am J Physiol Heart Circ Physiol 2011, 301:H12-H20.
20. Clerico A., Fontana M., Vittorini S., Emdin M. The search for a pathophysiological link between gender, cardiac endocrine function, body mass regulation and cardiac mortality: proposal for a working hypothesis. Clin Chim Acta 2009, 405:1-7.
21. Clerico A., Giannoni A., Vittorini S., Emdin M. The paradox of low BNP levels in obesity. Heart Fail Rev 2012, 17:81-96.
22. Storrow A.B., Nowak R.M., Diercks D.B., Singer A.J., Wu A.H., Kulstad E., et al. Absolute and relative changes (delta) in troponin i for early diagnosis of myocardial infarction: results of a prospective multicenter trial. Clin Biochem 2014, (epub ahead of print).
23. Apple F.S. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem 2009, 55:1303-1306.
24. Shah A.S., Griffiths M., Lee K.K., McAllister D.A., Hunter A.L., Ferry A.V., et al. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study. BMJ 2015, 350:g7873.
25. Eggers K.M., Johnston N., James S., Lindahl B., Venge P. Cardiac troponin i levels in patients with non-st-elevation acute coronary syndrome-the importance of gender. Am Heart J 2014, 168:317-324.
26. Dallmeier D., Denkinger M., Peter R., Rapp K., Jaffe A.S., Koenig W., et al. Sex-specific associations of established and emerging cardiac biomarkers with all-cause mortality in older adults: The ActiFE Study. Clin Chem 2014, 2:389-399.
27. Ungerer J.P., Marquart L., O'Rourke P.K., Wilgen U., Pretorius C.J. Concordance, variance, and outliers in 4 contemporary cardiac troponin assays: implications for harmonization. Clin Chem 2012, 58:274-283.
28. Ungerer J.P., Pretorius C.J., Dimeski G., O'Rourke P.K., Tyack S.A. Falsely elevated troponin i results due to outliers indicate a lack of analytical robustness. Ann Clin Biochem 2010, 47:242-247.
29. Pretorius C.J., Dimeski G., O'Rourke P.K., Marquart L., Tyack S.A., Wilgen U., et al. Outliers as a cause of false cardiac troponin results: investigating the robustness of 4 contemporary assays. Clin Chem 2011, 57:710-718.