Up regulation of liver-enriched transcription factors HNF4a and HNF6 and liver-specific microRNA (miR-122) by inhibition of let-7b in mesenchymal stem cells

Chemical Biology and Drug Design

Volumn 85, Issue 3, 2015, Pages 268-279

  Alizadeh, Effat ^a   Akbarzadeh, Abolfazl ^a   Eslaminejad, Mohamadreza Baghaban ^b   Barzegar, Abolfazl ^c   Hashemzadeh, Shahryar ^d   Nejati Koshki, Kazem ^a   Zarghami, Nosratollah ^a,e  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^c UNIVERSITY OF TABRIZ   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Adipose tissue; Hepatogenic differentiation; HNF4 ; HNF6; Inhibition; Let 7b; Mesenchymal stem cells; MiR 122

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HEPATOCYTE NUCLEAR FACTOR 6; MICRORNA; MICRORNA 122; MICRORNA LET7A; MICRORNA LET7B; MICRORNA LET7C; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, HUMAN; MIRN122 MICRORNA, HUMAN; MIRNLET7 MICRORNA, HUMAN;

ADULT; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER FUNCTION; MALE; MESENCHYMAL STEM CELL; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINDLE CELL; SUBCUTANEOUS FAT; UPREGULATION; ADIPOSE TISSUE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; G1 PHASE CELL CYCLE CHECKPOINT; GENETICS; LIVER; MESENCHYMAL STROMA CELL; METABOLISM;

ADIPOSE TISSUE; ADULT; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTE NUCLEAR FACTOR 6; HEPATOCYTES; HUMANS; LIVER; MALE; MESENCHYMAL STROMAL CELLS; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDES, ANTISENSE; UP-REGULATION;

EID: 84923020336     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12398     Document Type: Article

References (25)

1. Snykers S., De K.J., Tamara V., Rogiers V. (2011) Hepatic differentiation of mesenchymal stem cells: in vitro strategies. Methods Mol Biol;698:305-314.
2. Banas A. (2012) Purification of adipose tissue mesenchymal stem cells and differentiation toward hepaticlike cells. Methods Mol Bio;826:61-72.
3. Saulnier N., Piscaglia A.C., Puglisi M.A., Barba M., Arena V., Pani G., Alfieri S., Gasbarrini A. (2010) Molecular mechanisms underlying human adipose tissuederived stromal cells differentiation into a hepatocytelike phenotype. Dig Liver Dis;42:895-901.
4. Collino F., Bruno S., Deregibus M.C., Tetta C., Camussi G. (2011) MicroRNAs and mesenchymal stem cells. Vitam Horm;87:291-320.
5. Guo L., Zhao R.C., Wu Y. (2011) The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol;39:608-616.
6. Cui L., Zhou X., Li J., Wang L., Wang J., Li Q., Chu J., Zheng L., Wu Q., Han Z., Shi Y., Han Y., Fan D. (2012) Dynamic microRNA profiles of hepatic differentiated human umbilical cord lining-derived mesenchymal stem cells. PLoS ONE;7:e44737.
7. Sladek F.M., Zhong W.M., Lai E., Darnell J.E. Jr, Darnell J.E. Jr (1990) Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev;4:2353-2365.
8. Taraviras S., Monaghan A.P., Schutz G., Kelsey G. (1994) Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech Dev;48:67-79.
9. Deng X.G., Qiu R.L., Wu Y.H., Li Z.X., Xie P., Zhang J., Zhou J.J., Zeng L.X., Tang J., Maharjan A., Deng J.M. (2013) Overexpression of miR-122 promotes the hepatic differentiation and maturation of mouse ESCs through a miR-122/FoxA1/HNF4a-positive feedback loop. Liver Int;34:281-295.
10. Laudadio I., Manfroid I., Achouri Y., Schmidt D., Wilson M.D., Cordi S., Thorrez L., Knoops L., Jacquemin P., Schuit F., Pierreux C.E., Odom D.T., Peers B., Lemaigre F.P. (2012) A feedback loop between the liver-enriched transcription factor network and Mir-122 controls hepatocyte differentiation. Gastroenterology; 142:119-129.
11. Li Z.Y., Xi Y., Zhu W.N., Zeng C., Zhang Z.Q., Guo Z.C., Hao D.L., Liu G., Feng L., Chen H.Z., Chen F., Lv X., Liu D.P., Liang C.C. (2011) Positive regulation of hepatic miR-122 expression by HNF4 + |. J Hepatol; 55:602-611.
12. Wang K.H., Kao A.P., Singh S., Yu S.L., Kao L.P., Tsai Z.Y., Lin S.D., Li S.S. (2010) Comparative expression profiles of mRNAs and microRNAs among human mesenchymal stem cells derived from breast, face, and abdominal adipose tissues. Kaohsiung J Med Sci;26:113-122.
13. Seo M.J., Suh S.Y., Bae Y.C., Jung J.S. (2005) Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun;328:258-264.
14. Shafaei H., Esmaeili A., Mardani M., Razavi S., Hashemibeni B., Nasr-Esfahani M.H., Shiran M.B., Esfandiari E. (2011) Effects of human placental serum on proliferation and morphology of human adipose tissue-derived stem cells. Bone Marrow Transplant; 46:1464-1471.
15. Puglisi M.A., Saulnier N., Piscaglia A.C., Tondi P., Agnes S., Gasbarrini A. (2011) Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives. Eur Rev Med Pharmacol Sci;15:355-364.
16. Liu D., Fan J., Zeng W., Zhou Y., Ingvarsson S., Chen H. (2010) Quantitative analysis of miRNA expression in several developmental stages of human livers. Hepatol Res;40:813-822.
17. Gurtan A.M.S., Phillip A. (2013) The role of miRNAs in regulating gene expression networks. In I J Mol Bio;00:3582-3600.
18. Barh D.M., Malhotra R., Ravi B., Sindhurani P. (2010) MicroRNA let-7: an emerging next-generation cancer therapeutic. Curr Oncol;17:70-80.
19. Goff L.A., Boucher S., Ricupero C.L., Fenstermacher S., Swerdel M., Chase L.G., Adams C.C., Chesnut J., Lakshmipathy U., Hart R.P. (2008) Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Exp Hematol;36:1354-1369.
20. Koh W., Sheng C.T., Tan B., Lee Q.Y., Kuznetsov V., Kiang L.S., Tanavde V. (2010) Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha. BMC Genomics;11(Suppl 1):S6:1-15
21. Briancon N., Bailly A., Clotman F., Jacquemin P., Lemaigre F.P., Weiss M.C. (2004) Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver. J Biol Chem;279:33398-33408.
22. Talens-Visconti R., Bonora A., Jover R., Mirabet V., Carbonell F., Castell J.V., Gómez-Lechón M.J. (2006) Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J Gastroenterol; 12:5834-5845.
23. Doddapaneni R., Chawla Y.K., Das A., Kalra J.K., Ghosh S., Chakraborti A. (2013) Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells. J Cell Biochem; 114:1575-1583.
24. Xu H., He J.H., Xiao Z.-D., Zhang Q.-Q., Chen Y.-Q., Zhou H., Qu L.H. (2010) Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development. Hepatology;52:1431-1442.
25. Munoz-Alonso M.J., Leon J. (2003). G1 phase control and cell differentiation. In Johannes Boonstra, editor. Regulation of G1 Phase Progression. NY: Plenum Publishers; p. 236-246 Number of 236-46 pp.