Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

Oncotarget

Volumn 6, Issue 4, 2015, Pages 2064-2075

  Pandey, Poomy ^a   Rachagani, Satyanarayana ^b   Das, Srustidhar ^b   Seshacharyulu, Parthasarathy ^b   Sheinin, Yuri ^b   Naslavsky, Naava ^b   Pan, Zenggang ^c   Smith, Brittney L ^a   Peters, Haley L ^a,d   Radhakrishnan, Prakash ^a   McKenna, Nicole R ^a,e   Panapakkam Giridharan, Sai Srinivas ^b,f   Haridas, Dhanya ^b   Kaur, Sukhwinder ^b   Hollingsworth, Michael A ^a,b,c   MacDonald, Richard G ^a,b   Meza, Jane L ^a   Caplan, Steve ^a,b   Batra, Surinder K ^a,b,c   Solheim, Joyce C ^a,b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

^f UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Actin; Amyloid precursor like protein 2; Metastasis; Migration; Pancreatic cancer

Indexed keywords

AMYLOID PRECURSOR LIKE PROTEIN 2; AMYLOID PRECURSOR PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; APLP2 PROTEIN, HUMAN; DOXYCYCLINE; NERVE PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DIAPHRAGM METASTASIS; DOWN REGULATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LYMPH NODE METASTASIS; MESENTERY LYMPH NODE; METASTASIS; MOUSE; NONHUMAN; OVARY METASTASIS; PANCREAS CANCER; PERITONEUM METASTASIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; SMALL INTESTINE METASTASIS; SPLEEN METASTASIS; ANIMAL; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; FLOW CYTOMETRY; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER TUMOR; LUNG TUMOR; METABOLISM; NUDE MOUSE; PANCREAS TUMOR; PATHOLOGY; RNA INTERFERENCE; SECONDARY; TUMOR CELL LINE; TUMOR VOLUME;

ACTIN CYTOSKELETON; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; DOXYCYCLINE; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; LUNG NEOPLASMS; MICE, NUDE; NERVE TISSUE PROTEINS; PANCREATIC NEOPLASMS; RNA INTERFERENCE; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84923013443     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2990     Document Type: Article

References (24)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90.
2. Michl P, Gress TM. Current concepts and novel targets in advanced pancreatic cancer. Gut. 2013; 62: 317-326.
3. Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, Della Peruta M, Bassi C, Miyazaki K, Sorio C. Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers. FASEB J. 2005; 19: 1125-1127.
4. Tuli A, Sharma M, Wang X, Simone LC, Capek HL, Cate S, Hildebrand WH, NasLavsky N, Caplan S, Solheim JC. Amyloid precursor-like protein 2 association with HLA class I molecules. Cancer Immunol Immunother. 2009; 58: 1419-1431.
5. Peters HL, Tuli A, Wang X, Liu C, Pan Z, Ouellette MM, Hollingsworth MA, MacDonald RG, Solheim JC. Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells. Int J Oncol. 2012; 41: 1464-1474.
6. Abba MC, Drake JA, Hawkins KA, Hu Y, Sun H, Notcovich C, Gaddis S, Sahin A, Baggerly K, Aldaz CM. Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression. Breast Cancer Res. 2004; 6: 499-513.
7. Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability. J Cell Sci. 2012; 125:4219-4229.
8. Tuli A, Sharma M, McIlhaney MM, Talmadge JE, Naslavsky N, Caplan S, Solheim JC. Amyloid precursor-lie protein 2 increases the endocytosis, instability, and turnover of the H2-Kd MHC class I molecule. J Immunol. 2008; 181: 1978-1987.
9. Tuli A, Sharma M, Capek HL, Naslavsky N, Caplan S, Solheim JC. Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation. J Biol Chem. 2009; 284: 34296-34307.
10. Chang MY, Chan CK, Braun KR, Green PS, O'Brien KD, Chait A, Day AJ, Wight TN. Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix. J Biol Chem. 2012; 287: 14122-14135.
11. Yamaguchi H, Wyckoff J, Condeelis J. Cell migration in tumors. Curr Opin Cell Biol. 2005; 17: 559-564.
12. Weaver AM. Invadopodia: specialized cell structures for cancer invasion. Clin Exp Metastasis. 2006; 23: 97-105.
13. Yamaguchi H, Condeelis J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta. 2007; 1773: 642-652.
14. Hall A. The cytoskeleton and cancer. Cancer Metastasis Rev. 2009; 28: 5-14.
15. McLoughlin DM, Miller CCJ. The FE65 proteins and Alzheimer's disease. J Neurosci Res. 2008; 86: 744-754.
16. Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997; 272: 32869-32877.
17. Gertler F and Condeelis J. Metastasis: tumor cells becoming MENAcing. Trends Cell Biol. 2011; 21: 81-90.
18. Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res. 2004; 64: 622-630.
19. Guo J, Thinakaran G, Guo Y, Sisodia SS, Yu FX. A role for amyloid precursor-like protein 2 in corneal epithelial would healing. Invest Ophthalmol Vis Sci. 1998; 39: 292-300.
20. Pino MS, Balsamo M, Di Modugno F, Mottolese M, Alessio M, Melucci E, Milella M, McConkey DJ, Philippar U, Gertler FB, Natali PG, Nistico P. Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res. 2008; 14: 4943-4950.
21. Pandey P, Seshacharyulu P, Das S, Rachagani S, Ponnusamy MP, Yan Y, Johansson SL, Datta K, Lin ML, Batra SK. Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway. Brit J Cancer 2013; 108:2590-2600.
22. Iwamura T, Katsuki T, Ide K. Establishment and characterization of a human pancreatic cancer cell line (SUIT-2) producing carcinoembryonic antigen and carbohydrate antigen 19-9. Jpn J Cancer Res. 1987; 78:54-62.
23. Taniguchi S, Iwamura T, Katsuki T. Correlation between spontaneous metastatic potential and type I collagenolytic activity in a human pancreatic cancer cell line (SUIT-2) and sublines. Clin Exp Metastasis 1992; 10:259-266.
24. Tsutsumida H, Swanson BJ, Singh PK, Caffrey TC, Kitajima S, Goto M, Yonezawa S, Hollingsworth MA. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clin Cancer Res. 2006; 12:2976-2987.