메뉴 건너뛰기




Volumn 70, Issue 3, 2015, Pages 213-222

Resistance patterns and outcomes in intensive care unit (ICU)-acquired pneumonia. Validation of European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organisms

Author keywords

Appropriate antibiotic treatment; Intensive care; MDR; MDROs; Pneumonia; Sepsis; VAP

Indexed keywords

ACINETOBACTER; ADULT; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; DISEASE CLASSIFICATION; ENTEROBACTERIACEAE; ENTEROCOCCUS; FEMALE; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; INTENSIVE CARE UNIT; LEUKOCYTOSIS; LEUKOPENIA; LUNG INFILTRATE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIDRUG RESISTANCE; OBSERVATIONAL STUDY; PROPHYLAXIS; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; PUBLIC HEALTH; RISK FACTOR; SALMONELLA; SHIGELLA; STAPHYLOCOCCUS AUREUS; SURVIVAL; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; VENTILATOR ASSOCIATED PNEUMONIA; CLINICAL TRIAL; CROSS INFECTION; LENGTH OF STAY; MICROBIOLOGY; MIDDLE AGED; MULTICENTER STUDY; PNEUMONIA, BACTERIAL; PUBLIC HEALTH SERVICE; STATISTICAL MODEL; UNITED STATES; VALIDATION STUDY; VERY ELDERLY;

EID: 84922927615     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2014.10.004     Document Type: Article
Times cited : (131)

References (24)
  • 1
    • 0036151784 scopus 로고    scopus 로고
    • Factors impacting on the problem of antibiotic resistance
    • Available from:, [Internet]
    • Levy S.B. Factors impacting on the problem of antibiotic resistance. J Antimicrob Chemother 2002, 49(1):25-30. Available from:, [Internet]. http://jac.oxfordjournals.org/content/49/1/25.abstract.
    • (2002) J Antimicrob Chemother , vol.49 , Issue.1 , pp. 25-30
    • Levy, S.B.1
  • 2
    • 77950255824 scopus 로고    scopus 로고
    • The 10 x '20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020
    • Available from:, [Internet, cited 2014 Mar 29]
    • The 10 x '20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin Infect Dis 2010, 50(8):1081-1083. Available from:, [Internet, cited 2014 Mar 29]. http://www.ncbi.nlm.nih.gov/pubmed/20214473.
    • (2010) Clin Infect Dis , vol.50 , Issue.8 , pp. 1081-1083
  • 3
    • 84922862775 scopus 로고    scopus 로고
    • Risks for multidrug-resistant pathogens in the ICU
    • 9000, Publish Ah. Available from
    • Martín-Loeches I, Diaz E, Vallés J. Risks for multidrug-resistant pathogens in the ICU. Curr Opin Crit Care [Internet]. 9000; Publish Ah. Available from: http://journals.lww.com/co-criticalcare/Fulltext/publishahead/Risks_for_multidrug_resistant_pathogens_in_the.99492.aspx.
    • Curr Opin Crit Care [Internet]
    • Martín-Loeches, I.1    Diaz, E.2    Vallés, J.3
  • 4
    • 0036498656 scopus 로고    scopus 로고
    • Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our Worst Nightmare?
    • Available from:, [Internet]
    • Livermore D.M. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our Worst Nightmare?. Clin Infect Dis 2002, 34(5):634-640. Available from:, [Internet]. http://cid.oxfordjournals.org/content/34/5/634.abstract.
    • (2002) Clin Infect Dis , vol.34 , Issue.5 , pp. 634-640
    • Livermore, D.M.1
  • 5
    • 57749107808 scopus 로고    scopus 로고
    • Bad bugs, no drugs: no ESKAPE! an updatefrom the Infectious Diseases Society of America
    • Available from:, [Internet cited 2012 Nov 1]
    • Boucher H.W., Talbot G.H., Bradley J.S., Edwards J.E., Gilbert D., Rice L.B., et al. Bad bugs, no drugs: no ESKAPE! an updatefrom the Infectious Diseases Society of America. Clin Infect Dis 2009, 48(1):1-12. Available from:, [Internet cited 2012 Nov 1]. http://cid.oxfordjournals.org/content/48/1/1.abstract.
    • (2009) Clin Infect Dis , vol.48 , Issue.1 , pp. 1-12
    • Boucher, H.W.1    Talbot, G.H.2    Bradley, J.S.3    Edwards, J.E.4    Gilbert, D.5    Rice, L.B.6
  • 7
    • 84857646835 scopus 로고    scopus 로고
    • Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
    • Available from:, [Internet cited 2014 Jan 26]
    • Magiorakos A.-P., Srinivasan A., Carey R.B., Carmeli Y., Falagas M.E., Giske C.G., et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012, 18(3):268-281. Available from:, [Internet cited 2014 Jan 26]. http://www.ncbi.nlm.nih.gov/pubmed/21793988.
    • (2012) Clin Microbiol Infect , vol.18 , Issue.3 , pp. 268-281
    • Magiorakos, A.-P.1    Srinivasan, A.2    Carey, R.B.3    Carmeli, Y.4    Falagas, M.E.5    Giske, C.G.6
  • 8
    • 0035864837 scopus 로고    scopus 로고
    • Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    • Availablefrom:, [Internet]
    • Hilbert G., Gruson D., Vargas F., Valentino R., Gbikpi-Benissan G., Dupon M., et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001, 344(7):481-487. Availablefrom:, [Internet]. http://www.nejm.org/doi/full/10.1056/NEJM200102153440703.
    • (2001) N Engl J Med , vol.344 , Issue.7 , pp. 481-487
    • Hilbert, G.1    Gruson, D.2    Vargas, F.3    Valentino, R.4    Gbikpi-Benissan, G.5    Dupon, M.6
  • 9
    • 0025809112 scopus 로고
    • Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid
    • Available from:, [Internet, cited 2014 Jun 6]
    • Pugin J., Auckenthaler R., Mili N., Janssens J.P., Lew P.D., Suter P.M. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 1991, 143(5 Pt 1):1121-1129. Available from:, [Internet, cited 2014 Jun 6]. http://www.ncbi.nlm.nih.gov/pubmed/2024824.
    • (1991) Am Rev Respir Dis , vol.143 , Issue.5 , pp. 1121-1129
    • Pugin, J.1    Auckenthaler, R.2    Mili, N.3    Janssens, J.P.4    Lew, P.D.5    Suter, P.M.6
  • 10
    • 84875424552 scopus 로고    scopus 로고
    • Potentially resistant microorganisms in incubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors
    • Available from:, [Internet. Springer-Verlag; cited 2013 Mar 4]
    • Martin-Loeches I., Deja M., Koulenti D., Dimopoulos G., Marsh B., Torres A., et al. Potentially resistant microorganisms in incubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med 2013, 672-681. Available from:, [Internet. Springer-Verlag; cited 2013 Mar 4]. http://www.ncbi.nlm.nih.gov/pubmed/23358539.
    • (2013) Intensive Care Med , pp. 672-681
    • Martin-Loeches, I.1    Deja, M.2    Koulenti, D.3    Dimopoulos, G.4    Marsh, B.5    Torres, A.6
  • 11
    • 13644269309 scopus 로고    scopus 로고
    • Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia
    • Available from:, [Internet, cited 2012 Oct 28]
    • Pneumonia H. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171(4):388-416. Available from:, [Internet, cited 2012 Oct 28]. http://www.ncbi.nlm.nih.gov/pubmed/15699079.
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.4 , pp. 388-416
    • Pneumonia, H.1
  • 12
    • 77749343661 scopus 로고    scopus 로고
    • Validation of the American Thoracic Society-Infectious Diseases Society of America guidelines for hospital-acquired pneumonia in the intensive care unit
    • Available from:, [Internet, cited 2012 Dec 12]
    • Ferrer M., Liapikou A., Valencia M., Esperatti M., Theessen A., Antonio Martinez J., et al. Validation of the American Thoracic Society-Infectious Diseases Society of America guidelines for hospital-acquired pneumonia in the intensive care unit. Clin Infect Dis 2010, 50(7):945-952. Available from:, [Internet, cited 2012 Dec 12]. http://www.ncbi.nlm.nih.gov/pubmed/20175690.
    • (2010) Clin Infect Dis , vol.50 , Issue.7 , pp. 945-952
    • Ferrer, M.1    Liapikou, A.2    Valencia, M.3    Esperatti, M.4    Theessen, A.5    Antonio Martinez, J.6
  • 13
    • 43349093647 scopus 로고    scopus 로고
    • Effects of systemic antibiotic therapy on bacterial persistence in the respiratory tract of mechanically ventilated patients
    • Available from:, [Internet, cited 2014 Aug 30]
    • Visscher S., Schurink C.A.M., Melsen W.G., Lucas P.J.F., Bonten M.J.M. Effects of systemic antibiotic therapy on bacterial persistence in the respiratory tract of mechanically ventilated patients. Intensive Care Med 2008, 34(4):692-699. Available from:, [Internet, cited 2014 Aug 30]. http://www.ncbi.nlm.nih.gov/pubmed/18180901.
    • (2008) Intensive Care Med , vol.34 , Issue.4 , pp. 692-699
    • Visscher, S.1    Schurink, C.A.M.2    Melsen, W.G.3    Lucas, P.J.F.4    Bonten, M.J.M.5
  • 14
    • 84922862774 scopus 로고    scopus 로고
    • Recurrence of Gram-negative nosocomial pneumonia in the critically ill patient following short-course antibiotic therapy
    • Available from:, [Internet, cited 2014 Aug 30]
    • Pugh R., Cooke R., Dempsey G. Recurrence of Gram-negative nosocomial pneumonia in the critically ill patient following short-course antibiotic therapy. Crit Care 2007, 11(Suppl. 4):P33. Available from:, [Internet, cited 2014 Aug 30]. http://ccforum.com/content/11/S4/P33.
    • (2007) Crit Care , vol.11 , pp. P33
    • Pugh, R.1    Cooke, R.2    Dempsey, G.3
  • 15
    • 84873714375 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012
    • Available from:, [Internet, cited 2013 Feb 27]
    • Dellinger R.P., Levy M.M., Rhodes A., Annane D., Gerlach H., Opal S.M., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013, 39(2):165-228. Available from:, [Internet, cited 2013 Feb 27]. http://www.ncbi.nlm.nih.gov/pubmed/23361625.
    • (2013) Intensive Care Med , vol.39 , Issue.2 , pp. 165-228
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3    Annane, D.4    Gerlach, H.5    Opal, S.M.6
  • 16
    • 0028784689 scopus 로고
    • Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome
    • Available from:, [Internet, cited 2013 Mar 29]
    • Marshall J.C., Cook D.J., Christou N.V., Bernard G.R., Sprung C.L., Sibbald W.J. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995, 23(10):1638-1652. Available from:, [Internet, cited 2013 Mar 29]. http://www.ncbi.nlm.nih.gov/pubmed/7587228.
    • (1995) Crit Care Med , vol.23 , Issue.10 , pp. 1638-1652
    • Marshall, J.C.1    Cook, D.J.2    Christou, N.V.3    Bernard, G.R.4    Sprung, C.L.5    Sibbald, W.J.6
  • 17
    • 1842738502 scopus 로고    scopus 로고
    • Causes and predictors of nonresponse to treatment of intensive care unit-acquired pneumonia
    • Available from:, [Internet, cited 2013 Mar 29]
    • Ioanas M., Ferrer M., Cavalcanti M., Ferrer R., Ewig S., Filella X., et al. Causes and predictors of nonresponse to treatment of intensive care unit-acquired pneumonia. Crit Care Med 2004, 32(4):938-945. Available from:, [Internet, cited 2013 Mar 29]. http://www.ncbi.nlm.nih.gov/pubmed/15071382.
    • (2004) Crit Care Med , vol.32 , Issue.4 , pp. 938-945
    • Ioanas, M.1    Ferrer, M.2    Cavalcanti, M.3    Ferrer, R.4    Ewig, S.5    Filella, X.6
  • 18
    • 79952420498 scopus 로고    scopus 로고
    • Current concepts in antimicrobial therapy against resistant gram-negative organisms: extended-spectrum beta-lactamase-producing enterobacteriaceae, carbapenem-resistant enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa
    • Available from:, [Internet, cited 2013 Mar 2]
    • Kanj S.S., Kanafani Z.A. Current concepts in antimicrobial therapy against resistant gram-negative organisms: extended-spectrum beta-lactamase-producing enterobacteriaceae, carbapenem-resistant enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa. Mayo Clin Proc 2011, 86(3):250-259. Available from:, [Internet, cited 2013 Mar 2]. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3046948%26tool=pmcentrez%26rendertype=abstract.
    • (2011) Mayo Clin Proc , vol.86 , Issue.3 , pp. 250-259
    • Kanj, S.S.1    Kanafani, Z.A.2
  • 19
    • 78650211212 scopus 로고    scopus 로고
    • Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients
    • Available from:, [Internet, cited 2014 Aug 30]
    • Esperatti M., Ferrer M., Theessen A., Liapikou A., Valencia M., Saucedo L.M., et al. Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients. Am J Respir Crit Care Med 2010, 182(12):1533-1539. Available from:, [Internet, cited 2014 Aug 30]. http://www.ncbi.nlm.nih.gov/pubmed/20693381.
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.12 , pp. 1533-1539
    • Esperatti, M.1    Ferrer, M.2    Theessen, A.3    Liapikou, A.4    Valencia, M.5    Saucedo, L.M.6
  • 20
    • 27744470133 scopus 로고    scopus 로고
    • Both early-onset and late-onset ventilator-associated pneumonia are caused mainly by potentially multiresistant bacteria
    • Available from:, [Internet, cited 2014 Mar 12]
    • Giantsou E., Liratzopoulos N., Efraimidou E., Panopoulou M., Alepopoulou E., Kartali-Ktenidou S., et al. Both early-onset and late-onset ventilator-associated pneumonia are caused mainly by potentially multiresistant bacteria. Intensive Care Med 2005, 31(11):1488-1494. Available from:, [Internet, cited 2014 Mar 12]. http://www.ncbi.nlm.nih.gov/pubmed/16151723.
    • (2005) Intensive Care Med , vol.31 , Issue.11 , pp. 1488-1494
    • Giantsou, E.1    Liratzopoulos, N.2    Efraimidou, E.3    Panopoulou, M.4    Alepopoulou, E.5    Kartali-Ktenidou, S.6
  • 21
    • 27144434764 scopus 로고    scopus 로고
    • Impact of clinical guidelines in the management of severe hospital-acquired pneumonia
    • Available from:, [Internet, cited 2014 May 9]
    • Soo Hoo G.W., Wen Y.E., Nguyen T.V., Goetz M.B. Impact of clinical guidelines in the management of severe hospital-acquired pneumonia. Chest 2005, 128(4):2778-2787. Available from:, [Internet, cited 2014 May 9]. http://www.ncbi.nlm.nih.gov/pubmed/16236955.
    • (2005) Chest , vol.128 , Issue.4 , pp. 2778-2787
    • Soo Hoo, G.W.1    Wen, Y.E.2    Nguyen, T.V.3    Goetz, M.B.4
  • 22
    • 0142211279 scopus 로고    scopus 로고
    • Are infections due to resistant pathogens associated with a worse outcome in critically ill patients?
    • Available from:, [Internet, cited 2013 Dec 18]
    • Peres-Bota D., Rodriguez H., Dimopoulos G., DaRos A., Mélot C., Struelens M.J., et al. Are infections due to resistant pathogens associated with a worse outcome in critically ill patients?. JInfect 2003, 47(4):307-316. Available from:, [Internet, cited 2013 Dec 18]. http://www.ncbi.nlm.nih.gov/pubmed/14556755.
    • (2003) JInfect , vol.47 , Issue.4 , pp. 307-316
    • Peres-Bota, D.1    Rodriguez, H.2    Dimopoulos, G.3    DaRos, A.4    Mélot, C.5    Struelens, M.J.6
  • 23
    • 84863190438 scopus 로고    scopus 로고
    • Carbapenem antibiotics for serious infections
    • Available from:, [Internet, cited 2014 Aug 30]
    • Hawkey P.M., Livermore D.M. Carbapenem antibiotics for serious infections. BMJ 2012, 344:e3236. Available from:, [Internet, cited 2014 Aug 30]. http://www.ncbi.nlm.nih.gov/pubmed/22654063.
    • (2012) BMJ , vol.344 , pp. e3236
    • Hawkey, P.M.1    Livermore, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.