Bleeding reduction after topical application of tranexamic acid together with Betadine solution in total knee arthroplasty. A randomised controlled study

Orthopaedics and Traumatology: Surgery and Research

Volumn 101, Issue 1, 2015, Pages 83-87

  Carvalho, L H ^a,b   Frois Temponi, E ^a   Machado Soares, L F ^a   Goncalves M B J ^a   Paiva Costa, L ^a   Tavares de Souza, M L A ^a  

^a HOSPITAL MADRE TERESA   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Blood loss; Povidone iodine solution; Total knee arthroplasty; Tranexamic acid

Indexed keywords

ENOXAPARIN; HEMOGLOBIN; PLACEBO; POVIDONE IODINE; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; TOPICAL ANTIINFECTIVE AGENT;

AGED; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOSIS PREVENTION; TOPICAL TREATMENT; TOTAL KNEE REPLACEMENT; VENOUS THROMBOEMBOLISM; ADVERSE EFFECTS; DOSE RESPONSE; DRUG COMBINATION; FOLLOW UP; KNEE ARTHROPLASTY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AGED; ANTI-INFECTIVE AGENTS, LOCAL; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; POSTOPERATIVE HEMORRHAGE; POVIDONE-IODINE; PROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 84922922275     PISSN: None     EISSN: 18770568     Source Type: Journal    
DOI: 10.1016/j.otsr.2014.10.013     Document Type: Article

References (26)

1. Irisson E., Hémon Y., Pauly V., Parratte S., Argenson J.N., Kerbaul F. Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery. Orthop Traumatol Surg Res 2012, 98:477-483.
2. Biarnés Suñé A., Ciércoles Jiménez E., Márquez Martínez E., Medel Rebollo J., Godet Gimeno C., Roigé Solé J. Risk factors for transfusion in primary knee arthroplasty. Rev Esp Anestesiol Reanim 2006, 53(1):18-24. [Spanish].
3. Dillon C.F., Rasch E.K., Gu Q., Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94. J Rheumatol 2006, 33:2271-2279.
4. Good L., Peterson E., Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003, 90(5):569-596.
5. Sehat K.R., Evans R.L., Newman J.H. Hidden blood loss following hip and knee arthroplasty. Correct management of blood loss should take hidden loss into account. J Bone Joint Surg Br 2004, 86:561-565.
6. Bierbaum B.E., Callaghan J.J., Galante J.O., Rubash H.E., Tooms R.E., Welch R.B. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 1999, 81:2-10.
7. Bong M.R., Patel V., Chang E., Issack P.S., Hebert R., Di Cesare P.E. Risks associated with blood transfusion after total knee arthroplasty. J Arthroplasty 2004, 19:281-287.
8. Freedman J., Luke K., Monga N., Lincoln S., Koen R., Escobar M., et al. A provincial program of blood conservation: The Ontario Transfusion Coordinators (ONTraC). Transfus Apher Sci 2005, 33:343-349.
9. Wong J., Abrishami A., El Beheiry H., Mahomed N.N., Roderick Davey J., Gandhi R., et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a Randomized controlled trial. J Bone Joint Surg Am 2010, 92:2503-2513.
10. Roy S.P., Tanki U.F., Dutta A., JainSK NagiON. Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2012, 20:2494-2501.
11. Seo J.G., Moon Y.W., Park S.H., Kim S.M., Ko K.R. The comparative efficacies of intra-articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2013, 21:1869-1874.
12. Kim T.K., Chang C.B., Koh I.J. Practical issues for the use of tranexamic acid in total knee arthroplasty: a systematic review. Knee Surg Sports Traumatol Arthrosc 2014, 22:1849-1858.
13. Hill R.L., Casewell M.W. The in-vitro activity of povidone-iodine cream against Staphylococcus aureus and its bioavailability in nasal secretions. J Hosp Infect 2000, 45:198-205.
14. Reimer K., Wichelhaus T.A., Schafer V., et al. Antimicrobial effectiveness of povidone-iodine and consequences for new application areas. Dermatology 2002, 204(Suppl.1):114-120.
15. Brown N.M., Cipriano C.A., Moric M., Sporer S.M., Della Valle C.J. Dilute betadine lavage before closure for the prevention of acute postoperative deep periprosthetic joint infection. J Arthroplasty 2012, 27:27-30.
16. Chundamala J., Wright J.G. The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review. Can J Surg 2007, 50:473-481.
17. Cheng M.T., Chang M.C., Wang S.T., et al. Efficacy of dilute betadine solution irrigation in the prevention of postoperative infection of spinal surgery. Spine 2005, 30:1689-1693.
18. Dunn C.J., Goa K.L. Tranexamic acid: a review of its use in surgery and other indications. Drugs 1999, 57:1005-1032.
19. Engel J.M., Jojaus T., Ruwoldt R., et al. Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin. Anesth Analg 2001, 92:775.
20. Alshryda S., Sarda P., Sukeik M., et al. Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg Br 2011, 93-B:1577-1585.
21. Wind T.C., Barfield W.R., Moskal J.T. The effect of tranexamic acid on blood loss and transfusion rate in primary total knee arthroplasty. J Arthroplasty 2013, 28:1080-1083.
22. Eubanks J.D. Antifibrinolytics in major orthopaedic surgery. J Am Acad Orthop Surg 2010, 18:132-138.
23. Wu L.D., Chen W.P., Yang Z.G. Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Am 2012, 94:1153-1159.
24. Graham I.D., Alvarez G., Tetroe J., McAuley L., Laupacis A. Factors influencing the adoption of blood alternatives to minimize allogeneic transfusion: the perspective of eight Ontario hospitals. Can J Surg 2002, 45:132-140.
25. Li Z.J., Fu X., Tian P., Liu W.X., Li Y.M., Zheng Y.F., et al. Fibrin sealant before wound closure in total knee arthroplasty reduced blood loss: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 2014, Feb 12, [Epub ahead of print].
26. Massin P., Scemama C., Jeanrot C., Boyer P. Does fibrin sealant use in total knee replacement reduce transfusion rates? A non-randomised comparative study. Orthop Traumatol Surg Res 2012, 98(2):180-185.