Apparent histological changes of adipocytes after treatment with CL 316,243, a β-3-adrenergic receptor agonist

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 669-676

  Ghorbani, Masoud ^a,b   Teimourian, Shahram ^c   Farzad, Reza ^a   Asl, Nabiollah Namvar ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b UNIVERSITY OF OTTAWA   (Canada)

^c IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Brown adipose tissue; Cellularity of adipose tissue; Obesity; Thermogenesis; Uncoupling protein; Zucker rats

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; FATTY ACID; GLUCOSE; INSULIN; UNCOUPLING PROTEIN 1; 1,3 DIOXOLANE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; DISODIUM (R,R)-5-(2-((2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)-AMINO)PROPYL)-1,3-BENZODIOXOLE-2,3-DICARBOXYLATE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENERGY BALANCE; ENERGY EXPENDITURE; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HISTOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; LEYDIG CELL; LIPOLYSIS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; RAT; RESTING METABOLIC RATE; THERMOGENESIS; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECTS; METABOLISM; PATHOLOGY; RABBIT; STRUCTURE ACTIVITY RELATION; ZUCKER RAT;

ADIPOCYTES; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; DIOXOLES; MOLECULAR STRUCTURE; RABBITS; RATS; RATS, ZUCKER; RECEPTORS, ADRENERGIC, BETA-3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922876425     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S73891     Document Type: Article

References (22)

1. Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr. Differentiation of receptor systems activated by sympathomimetic amines. Nature. 1967;214(5088):597–598.
2. Bloom JD, Dutia MD, Johnson BD, et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 16,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. J Med Chem. 1992;35(16):3081–3084.
3. Arch JR, Kaumann AJ. Beta 3 and atypical beta-adrenoceptors. Med Res Rev. 1993;13(6):663–729.
4. Himms-Hagen J. Brown adipose tissue thermogenesis and obesity. Prog Lipid Res. 1989;28(2):67–115.
5. Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984;64(1):1–64.
6. Rousset S, Alves-Guerra MC, Mozo J, et al. The biology of mitochon-drial uncoupling proteins. Diabetes. 2004;53 Suppl 1:S130–S135.
7. Yoshida T, Umekawa T, Kumamoto K, et al. Beta 3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers. Am J Physiol. 1998;274(3 Pt 1):E469–E475.
8. Himms-Hagen J, Triandafillou J, Begin-Heick N, Ghorbani M, Kates AL. Apparent lack of beta 3-adrenoceptors and of insulin regulation of glucose transport in brown adipose tissue of guinea pigs. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1995;268(1):R98–R104.
9. Dolan JA, Muenkel HA, Burns MG, et al. Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines. J Pharmacol Exp Ther. 1994;269(3):1000–1006.
10. Ghorbani M, Claus TH, Himms-Hagen J. Hypertrophy of Brown Adipocites in Brown and White Adipose Tissue and Reversal of Diet-Induced Obesity in Rats Treated with a β3-Adrenoceptor Agonist. Biochem Pharmacol. 1997;54(1):121–131.
11. Bray GA. Commentary on classics in obesity. 5. Fat cell theory and units of knowledge. Obes Res. 1993;1(5):403–407.
12. Phillips FC, Cleary MP. Metabolic measurements among homozygous (fa/fa) obese, heterozygous (Fa/fa) lean and homozygous (Fa/Fa) lean Zucker rat pups at 17 days of age. J Nutr. 1994;124(8):1230–7123.
13. Géloën A, Collet AJ, Bukowiecki LJ. Role of sympathetic innervation in brown adipocyte proliferation. Am J Physiol. 1992;263(6 Pt 2): R1176–R1181.
14. Hirsch J, Gallian E. Methods for the determination of adipose cell size in man and animals. J Lipid Res. 1968;9(1):110–119.
15. Ma SW, Foster DO. Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo. Can J Physiol Pharmacol. 1986;64(5):609–614.
16. Ghorbani M, Shafiee Ardestani M, Hatami Gigloo S, Ahangari Cohan R, Nouri Inanlou D, Ghorban P. Anti Diabetic effect of CL 316,243 (A β3-Adrenergic Agonist) By Down Regulation of Tumour Necrosis Factor (TNF-α) Expression. Plos One. 2012;7(10):e45874.
17. No JI, Yang JY, Hyun HJ, Yeon CS, Choi HJ. Factors Associated with Serum Levels of Carcinoembryonic Antigen in Healthy Non-smokers. Korean J Fam Med. 2013;34(6):413–419.
18. Ghorbani M, Himms-Hagen J. Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord. 1997; 21(6):465–475.
19. Sanchez-Gurmaches J, Guertin DA. Adipocyte lineages: Tracing back the origins of fat. Biochim Biophys Acta. 2013;1842(3):340–351.
20. Macotela Y, Emanuelli B, Mori MA, et al. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes. 2012; 61(7):1691–1699.
21. Milam KM, Keesey RE, Storlien LH, Stern JS. Developmental study of adipose cellularity in lateral hypothalamic-lesioned Zucker obese rats. Am J Physiol. 1982;242(3):R311–R317.
22. Cousin B, Cinti S, Morroni M, et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci. 1992;103(Pt 4):931–942.