In search of evidence-based treatment for concussion: Characteristics of current clinical trials

Brain Injury

Volumn 29, Issue 3, 2015, Pages 300-305

  Burke, Matthew J ^a   Fralick, Michael ^b   Nejatbakhsh, Nasrin ^c   Tartaglia, Maria C ^a,d   Tator, Charles H ^c,d  

^a Division of Neurology   (Canada)

^b General Internal Medicine   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Brain concussion; Brain injuries; Clinical trials; Post concussion syndrome; Therapeutics

Indexed keywords

ARTICLE; BRAIN CONCUSSION; BRAIN INJURY; CLINICAL TRIAL (TOPIC); COGNITIVE THERAPY; DIET SUPPLEMENTATION; EVIDENCE BASED PRACTICE; HUMAN; NEUROPSYCHOLOGICAL TEST; REST; TRAUMATIC BRAIN INJURY; EVIDENCE BASED MEDICINE; INJURY SCALE; PROCEDURES; RETROSPECTIVE STUDY;

BRAIN CONCUSSION; CLINICAL TRIALS AS TOPIC; COGNITIVE THERAPY; EVIDENCE-BASED MEDICINE; HUMANS; NEUROPSYCHOLOGICAL TESTS; RETROSPECTIVE STUDIES; TRAUMA SEVERITY INDICES;

EID: 84922832779     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.3109/02699052.2014.974673     Document Type: Article

References (34)

1. McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorák J, Echemendia RJ, Engebretsen L, Johnston K, Kutcher JS, Raftery M, et al. Consensus statement on concussion in sport: The 4th International Conference on Concussion in Sport held in Zurich, November 2012. British Journal of Sports Medicine 2013;47: 250-258
2. Collins MW, Lovell MR, Mckeag DB. Current issues in managing sports-related concussion. The Journal of the American Medical Association 1999;282:2283-2285
3. Giza CC, Kutcher JS, Ashwal S, Barth J, Getchius TS, Gioia GA, Gronseth GS, Guskiewicz K, ManDel S, Manley G, et al. Summary of eviDence-based guiDeline update: Evaluation and management of concussion in sports: Report of the GuiDeline Development Subcommittee of the American AcaDemy of Neurology. Neurology 2013;80:2250-2257
4. Harmon KG, Drezner JA, Gammons M, Guskiewicz K, Halstead M, Herring S, Kutcher J, Pana A, Putukian M, Roberts W. American Medical Society for Sports Medicine position statement: Concussion in sport. British Journal of Sports Medicine 2013;47: 15-26
5. SchneiDer KJ, Iverson GL, Emery CA, McCrory P, Herring SA, Meeuwisse WH. The effects of rest and treatment following sportrelated concussion: A systematic review of the literature. British Journal of Sports Medicine 2013;47:304-307
6. Zarin DA, Tse T, Williams RJ, Califf RM, IDe NC. The ClinicalTrials.gov results database: Update and key issues. New England Journal of Medicine 2011;364:852-860
7. Dickersin K, Rennie D. The evolution of trial registries and their use to assess the clinical trial enterprise. The Journal of the American Medical Association 2012;307:1861-1864
8. De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, et al. Clinical trial registration: A statement from the International Committee of Medical Journal Editors. New England Journal of Medicine 2004; 351:1250-1251
9. Zarin DA, Tse T, IDe NC. Trial registration at ClinicalTrials.gov between May and October 2005. New England Journal of Medicine 2005;353:2279-2287
10. International Standards for Clinical Trial Registries [Internet]. World Health Organization; Available online at: http://www.who. int/ictrp/en, accessed 22 September 2013
11. Petraglia AL, Maroon JC, Bailes JE. From the field of play to the field of combat: A review of the pharmacological management of concussion. Neurosurgery 2012;70:1520-1533
12. Petraglia AL, Winkler EA, Bailes JE. Stuck at the bench: Potential natural neuroprotective compounds for concussion. Surgical Neurology International 2011;2:146
13. Barkhoudarian G, Hovda DA, Giza CC. The molecular pathophysiology of concussive brain injury. Clinics in Sports Medicine 2011;30:33-48
14. Tator CH. Concussions and their consequences: Current diagnosis, management and prevention. Canadian Medical Association Journal 2013;185:975-979
15. Califf R, Zarin D, Kramer JM, Sherman R, Aberle L, Tasneem A. Characteristics of clinical trials registered in ClinicalTrials.gov, 2007-2010. The Journal of the American Medical Association 2012;307:1838-1847
16. De Kruijk JR, Leffers P, Meerhoff S, Rutten J, Twijnstra A. Effectiveness of bed rest after mild traumatic brain injury: A randomised trial of no versus six days of bed rest. Journal of Neurology Neurosurgery, and Psychiatry 2002;73:167-172
17. Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. soldiers returning from Iraq. New England Journal of Medicine 2008;358:453-463
18. Meehan III WP. Medical therapies for concussion. Clinics in Sports Medicine 2011;30:115-124
19. Kirkwood MW, Yeates KO, Wilson PE. Pediatric-sport related concussion: A review of clinical management of an oft-neglected population. Pediatrics 2006;117:1359-1374
20. McCrory P, Collie A, AnDerson V, Davis G. Can we manage sportrelated concussion in children the same as adults? British Journal of Sports Medicine 2004;38:516-519
21. Bakhos LL, Lockhart GR, Myers R, Linakis JG. Emergency Department visits for concussion in young child athletes. Pediatrics 2010;126:e55-e556
22. Yusuf S, Collins R, Peto R. Why do we need some large, simple randomized trials? Statistics in Medicine 1984;3:409-422
23. DerSimonian R, Laird N. Meta-Analysis in clinical trials. Controlled Clinical Trials 1986;7:177-188
24. Comper P, Bisschop SM, CarniDe N, Tricco A. A systematic review of treatments for mild traumatic brain injury. Brain Injury 2005;19: 863-880
25. Tator CH. Lets standardize the Definition of concussion and get reliable inciDence data. The Canadian Journal of Neurological Sciences 2009;36:405-406
26. National Institute of Neurologic DisorDers and Stroke Common Data Elements [Internet]. Bethesda, MD: National Institute of Health; Available online at: http://www.commondataelements. ninds.nih.gov, accessed 5 March 2014
27. Moher D, Schulz KF, Altman D. CONSORT Group (Consolidated Standards of Reporting Trials). The CONSORT statement: Revised recommendations for improving the quality of reports of parallelgroup randomized trials. The Journal of the American Medical Association 2001;285:1987-1991
28. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ, GRADE Working Group. GRADE: An emerging consensus on rating quality of eviDence and strength on recommendations. British Medical Journal 2008;336:924-926
29. Jeter CB, HergenroeDer GW, Hylin MJ, ReDell JB, Moore AN, Dash PK. Biomarkers for the diagnosis and prognosis of mild traumatic brain injury/concussion. Journal of Neurotrauma 2013; 30:657-670
30. Zetterberg H, Smith DH, Blennow K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nature Reviews. Neurology 2013;9:201-210
31. Bigler ED. Neuroimaging biomarkers in mild traumatic brain injury. Neuropsychology Review 2013;23:169-209
32. Todd JL, White KR, Chiswell K, Tasneem A, Palmer SM. Using ClinicalTrials.gov to unDerstand the state of clinical research in pulmonary, critical care, and sleep medicine. Annals of the American Thoracic Society 2013;10:411-417
33. Belanger HG, Proctor-Weber Z, Kretzmer T, Kim M, French LM, VanDerploeg RD. Symptom complaints following reports of blast versus non-blast mild TBI: Does mechanism of injury matter? The Clinical Neuropsychologist 2011;25:702-715
34. Erickson JC. Treatment outcomes of chronic post-traumatic headaches after mild head trauma in US soldiers: An observational study. Headache 2011;51:932-944