Structure-activity relationship for the oxadiazole class of antibiotics

Journal of Medicinal Chemistry

Volumn 58, Issue 3, 2015, Pages 1380-1389

  Spink, Edward ^a   Ding, Derong ^a   Peng, Zhihong ^a   Boudreau, Marc A ^a   Leemans, Erika ^a   Lastochkin, Elena ^a   Song, Wei ^a   Lichtenwalter, Katerina ^a   O'Daniel, Peter I ^a   Testero, Sebastian A ^a   Pi, Hualiang ^a   Schroeder, Valerie A ^a   Wolter, William R ^a   Antunes, Nuno T ^a   Suckow, Mark A ^a   Vakulenko, Sergei ^a   Chang, Mayland ^a   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (1H INDOL 5 YL) 3 [4 [4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1,2,4 OXADIAZOLE; ANTIBIOTIC AGENT; OXADIAZOLE DERIVATIVE; PENICILLIN BINDING PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; BIOSYNTHESIS; CELL WALL; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT STAPHYLOCOCCUS AUREUS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXADIAZOLES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922819956     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501661f     Document Type: Article

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