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Volumn 54, Issue 2, 2015, Pages 678-682

Chemical assembly systems: Layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

Author keywords

Active pharmaceutical ingredients; Chemical assembly; Divergent synthesis; Flow chemsitry; amino acids

Indexed keywords

AMINO ACIDS; ASSEMBLY; BATCH DATA PROCESSING; CHEMICAL REACTIONS; CUSTOMER SATISFACTION;

EID: 84922798889     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201409765     Document Type: Article
Times cited : (122)

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    • note
    • The only change to the reaction conditions required occurs in module 3 for trisubstituted alkenes (gabapentin precursor); see the Supporting Information.
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    • note
    • The active enantiomer is (S)-pregabalin. While this system represents a racemic synthesis, the enatiopure material can easily be obtained through co-crystallization with (S)-mandelic acid; see the Supporting Information for details.
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    • The overall yield of gabapentin with respect to the other γ-amino acids can be attributed to incomplete conversion in module 3; see Table S6 and related discussion in the Supporting Information for details.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.