Successful treatment of Morbihan disease with long-term minocycline and its association with mast cell infiltration

Acta Dermato-Venereologica

Volumn 95, Issue 3, 2015, Pages 368-369

  Fujimoto, Noriki ^a   Mitsuru, Mariko ^a   Tanaka, Toshihiro ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; BETAMETHASONE; FERRIC HYDROXIDE; MINOCYCLINE; MUCIN; STEROID; TRYPTASE; BIOLOGICAL MARKER;

AGED; ARTICLE; ASYMPTOMATIC DISEASE; CASE REPORT; CELL INFILTRATION; DERMIS; DRUG DOSE INCREASE; DRUG WITHDRAWAL; ERYTHEMA; EYELID EDEMA; FACE EDEMA; GRANULOMATOUS INFLAMMATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LONG TERM CARE; MALE; MAST CELL; MONONUCLEAR CELL; MORBIHAN DISEASE; PRIORITY JOURNAL; SKIN BIOPSY; SKIN FIBROSIS; TREATMENT RESPONSE; BIOPSY; DRUG ADMINISTRATION; DRUG EFFECTS; FACIAL DERMATOSES; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHEDEMA; TIME; TREATMENT OUTCOME;

AGED; BIOMARKERS; BIOPSY; DRUG ADMINISTRATION SCHEDULE; ERYTHEMA; FACIAL DERMATOSES; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHEDEMA; MALE; MAST CELLS; MINOCYCLINE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84922788641     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-1954     Document Type: Article

References (15)

1. Nagasaka T, Koyama T, Matsumura K, Chen KR. Persistent lymphoedema in Morbihan disease: formation of perilymphatic epithelioid cell granulomas as a possible pathogenesis. Clin Exp Dermatol 2008; 33: 764–767.
2. Veraldi S, Persico MC, Francia C. Morbihan syndrome. Indian Dermatol Online J 2013; 4: 122–124.
3. Degos R, Civatte J, Beuve-Méry M. Nouveau cas d’oedème érythémateux facial chronique. Bull Soc Fr Dermatol Syph 1973; 80: 257.
4. Smith LA, Cohen DE. Successful long-term use of oral isotretinoin for the management of Morbihan disease: a case series report and review of the literature. Arch Dermatol 2012; 148: 1395–1398.
5. Marzano AV, Vezzoli P, Alessi E. Elephantoid oedema of the eyelids. J Eur Acad Dermatol Venereol 2004; 18: 459–462.
6. Lai TF, Leibovitch I, James C, Huilgol SC, Selva D. Rosacea lymphoedema of the eyelid. Acta Ophthalmol Scand 2004; 82: 765–767.
7. Bechara FG, Jansen T, Losch R, Altmeyer P, Hoffmann K. Morbihan’s disease: treatment with CO2 laser blepharoplasty. J Dermatol 2004; 31: 113–115.
8. Hu SW, Robinson M, Meehan SA, Cohen DE. Morbihan disease. Dermatol Online J 2012; 18: 27.
9. Fujimoto N, Honda S, Nakanishi G, Tachibana T, Tanaka T. Acquired idiopathic penile lymphedema: Successful prevention of acute phase progression with low-dose corticosteroids. J Dermatol 2014; 41: 157–159.
10. Bernardini FP, Kersten RC, Khouri LM, Moin M, Kulwin DR, Mutasim DF. Chronic eyelid lymphedema and acne rosacea. Report of two cases. Ophthalmology 2000; 107: 2220–2223.
11. Ranu H, Lee J, Hee TH. Therapeutic hotline: Successful treatment of Morbihan’s disease with oral prednisolone and doxycycline. Dermatol Ther 2010; 23: 682–685.
12. Mazzatenta C, Giorgino G, Rubegni P, de Aloe G, Fimiani M. Solid persistent facial oedema (Morbihan’s disease) following rosacea, successfully treated with isotretinoin and ketotifen. Br J Dermatol 1997; 137: 1020–1021.
13. Jansen T, Plewig G. The treatment of rosaceous lymphoedema. Clin Exp Dermatol 1997; 22: 57.
14. Jungfer B, Jansen T, Przybilla B, Plewig G. Solid persistent facial edema of acne: successful treatment with isotretinoin and ketotifen. Dermatology 1993; 187: 34–37.
15. Sandler C, Ekokoski E, Lindstedt KA, Vainio PJ, Finel M, Sorsa T, et al. Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C. Inflamm Res 2005; 54: 304–312.