Shorter time to target temperature is associated with poor neurologic outcome in post-arrest patients treated with targeted temperature management

Resuscitation

Volumn 88, Issue , 2015, Pages 114-119

  Perman, Sarah M ^a   Ellenberg, Jonas H ^b   Grossestreuer, Anne V ^b   Gaieski, David F ^b   Leary, Marion ^b   Abella, Benjamin S ^b   Carr, Brendan G ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cardiac arrest; Prognosis; Resuscitation; Targeted temperature management

Indexed keywords

ADULT; AFRICAN AMERICAN; ARTICLE; BRAIN HEMORRHAGE; BRAIN INJURY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEART ARREST; HUMAN; INCIDENCE; INDUCED HYPOTHERMIA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RETURN OF SPONTANEOUS CIRCULATION; SURVIVOR; TARGETED TEMPERATURE MANAGEMENT; TEMPERATURE; TIME; TREATMENT WITHDRAWAL; ADVERSE EFFECTS; BODY TEMPERATURE; BRAIN ISCHEMIA; CLINICAL TRIAL; DISEASE MANAGEMENT; MULTICENTER STUDY; PATHOPHYSIOLOGY; PENNSYLVANIA; PHYSIOLOGY; PROCEDURES; PROGNOSIS; REGISTER; RESUSCITATION; RISK ASSESSMENT; TIME FACTOR;

BODY TEMPERATURE; BRAIN ISCHEMIA; CARDIOPULMONARY RESUSCITATION; DISEASE MANAGEMENT; FEMALE; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; INCIDENCE; MALE; MIDDLE AGED; PENNSYLVANIA; PROGNOSIS; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; TIME FACTORS;

EID: 84922771313     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2014.10.018     Document Type: Article

References (22)

1. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563. 10.1056/NEJMoa003289.
2. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346(8):549-556. Hypothermia after Cardiac Arrest Study Group.
3. Polderman K.H. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med 2009, 37:S186-S202. 10.1097/CCM.0b013e3181aa5241.
4. Che D., Li L., Kopil C.M., Liu Z., Guo W., Neumar R.W. Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest*. Crit Care Med 2011, 39:1423-1430. 10.1097/CCM.0b013e318212020a.
5. Wolff B., Machill K., Schumacher D., Schulzki I., Werner D. Early achievement of mild therapeutic hypothermia and the neurologic outcome after cardiac arrest. Int J Cardiol 2009, 133:223-228. 10.1016/j.ijcard.2007.12.039.
6. Sendelbach S., Hearst M.O., Johnson P.J., Unger B.T., Mooney M.R. Effects of variation in temperature management on cerebral performance category scores in patients who received therapeutic hypothermia post cardiac arrest. Resuscitation 2012, 10.1016/j.resuscitation.2011.12.026.
7. Nielsen N., Hovdenes J., Nilsson F., et al. Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest. Acta Anaesthesiol Scand 2009, 53:926-934. 10.1111/j. 1399-6576.2009.02021.x.
8. Haugk M., Testori C., Sterz F., et al. Relationship between time to target temperature and outcome in patients treated with therapeutic hypothermia after cardiac arrest. Crit Care 2011, 15:R101. 10.1186/cc10116.
9. Neumar R.W., Nolan J.P., Adrie C., et al. Post-Cardiac Arrest Syndrome Epidemiology, Pathophysiology, Treatment, and Prognostication A Consensus Statement From the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008, 118:2452-2483. 10.1161/CIRCULATIONAHA.108.190652.
10. Oddo M., Schaller M.-D., Feihl F., Ribordy V., Liaudet L. From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest. Crit Care Med 2006, 34:1865-1873. 10.1097/01.CCM.0000221922.08878.49.
11. Gaieski D.F., Fuchs B., Carr B.G., Merchant R., et al. Practical implementation of therapeutic hypothermia after cardiac arrest. Hosp Pract 2009, 37:71-83.
12. Jennett B., Bond M. Assessment of outcome after severe brain damage: a practical scale. Lancet 1975, 305:480-484. 10.1016/S0140-6736(75)92830-5.
13. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med 1986, 314:397-403. Brain Resuscitation Clinical Trial I Study group (BRCT-1).
14. Becker L.B., Aufderheide T.P., Geocadin R.G., et al. Primary outcomes for resuscitation science studies a consensus statement from the American Heart Association. Circulation 2011, 124:2158-2177. 10.1161/CIR.0b013e3182340239.
15. Chan P.S., Nallamothu B.K., Krumholz H.M., et al. Long-term outcomes in elderly survivors of in-hospital cardiac arrest. N Engl J Med 2013, 368:1019-1026. 10.1056/NEJMoa1200657.
16. Benz-Woerner J., Delodder F., Benz R., et al. Body temperature regulation and outcome after cardiac arrest and therapeutic hypothermia. Resuscitation 2012, 83:338-342. 10.1016/j.resuscitation.2011.10.026.
17. Morrison S.F., Nakamura K. Central neural pathways for thermoregulation. Front Biosci J Virtual Libr 2011, 16:74-104.
18. Nair S.U., Lundbye J.B. The occurrence of shivering in cardiac arrest survivors undergoing therapeutic hypothermia is associated with a good neurologic outcome. Resuscitation 2013, 84:626-629. 10.1016/j.resuscitation.2012.11.018.
19. Samaniego E.A., Persoon S., Wijman C.A.C. Prognosis after cardiac arrest and hypothermia: a new paradigm. Curr Neurol Neurosci Rep 2010, 11:111-119. 10.1007/s11910-010-0148-9.
20. Friberg H., Rundgren M., Westhall E., Nielsen N., Cronberg T. Continuous evaluation of neurological prognosis after cardiac arrest. Acta Anaesthesiol Scand 2013, 57:6-15. 10.1111/j. 1399-6576.2012.02736.x.
21. Sawyer K.N., Kurz M.C., Elswick R.K. Virginia Commonwealth University ARCTIC Investigators. An investigation of a hypothermic to ischemic ratio in patients following out-of-hospital cardiac arrest presenting with a shockable rhythm. Ther Hypothermia Temp Manag 2014, 4:72-78. 10.1089/ther.2013.0023.
22. Nielsen N., Wetterslev J., Cronberg T., et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013, 369:2197-2206. 10.1056/NEJMoa1310519.