A CALR mutation preceding BCR-ABL1 in an atypical myeloproliferative neoplasm

New England Journal of Medicine

Volumn 372, Issue 7, 2015, Pages 688-690

  Cabagnols, Xénia ^a   Cayuela, Jean Michel ^b   Vainchenker, William ^c  

^a INSERM   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CALRETICULIN; DASATINIB; ERYTHROPOIETIN; HEMOGLOBIN; HYDROXYUREA; IMATINIB; PEGINTERFERON ALPHA; BCR-ABL1 FUSION PROTEIN, HUMAN;

AGED; ANEMIA; BONE MARROW BIOPSY; CASE REPORT; DISEASE CLASSIFICATION; ERYTHROCYTE; FEMALE; FUSION GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; LETTER; LEUKOCYTE COUNT; MYELOPROLIFERATIVE NEOPLASM; PHILADELPHIA 1 CHROMOSOME; PHYSICAL EXAMINATION; SPLENOMEGALY; THROMBOCYTOSIS; CHRONIC MYELOID LEUKEMIA; GENETICS; MUTATION; MYELOPROLIFERATIVE DISORDER;

AGED; CALRETICULIN; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MUTATION; MYELOPROLIFERATIVE DISORDERS; THROMBOCYTOSIS;

EID: 84922726865     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1413718     Document Type: Letter

References (5)

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2. Them NC, Kralovics R. Genetic basis of MPN: beyond JAK2-V617F. Curr Hematol Malig Rep 2013;8:299-306.
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4. Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 2013;369:2391-405.
5. Yamada O, Mahfoudhi E, Plo I, et al. Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone. J Clin Oncol 2014;32(21):e76-e79.