A comparison of dexmedetomidine and placebo on the plasma concentrations of NGF, BDNF, GDNF, and epinephrine during severe alcohol withdrawal

Alcohol

Volumn 49, Issue 1, 2015, Pages 15-19

  Reynolds, Paul M ^a,b   Mueller, Scott W ^a   MacLaren, Robert ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO HOSPITAL   (United States)

Author keywords

Alcohol withdrawal; Brain derived neurotrophic growth factor; Dexmedetomidine; Epinephrine; Glial cell derived neurotrophic growth factor; Nerve growth factor

Indexed keywords

ADRENALIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DEXMEDETOMIDINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LORAZEPAM; NERVE GROWTH FACTOR; PLACEBO; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; NGF PROTEIN, HUMAN;

ADRENALIN BLOOD LEVEL; ALCOHOL WITHDRAWAL; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG MEGADOSE; HUMAN; LOW DRUG DOSE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; ALCOHOLISM; BLOOD; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; FEMALE; MALE; PLACEBO EFFECT; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ALCOHOLISM; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; EPINEPHRINE; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MALE; NERVE GROWTH FACTOR; PLACEBO EFFECT; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84922683783     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2014.11.006     Document Type: Article

References (24)

1. Airaksinen M.S., Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nature Reviews. Neuroscience 2002, 3:383-394.
2. Bleich S., Hillemacher T. Homocysteine, alcoholism and its molecular networks. Pharmacopsychiatry 2009, 42(Suppl 1):S102-S109.
3. Blum R., Konnerth A. Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions. Physiology (Bethesda) 2005, 20:70-78.
4. Carnicella S., Ahmadiantehrani S., Janak P.H., Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcoholism: Clinical and Experimental Research 2009, 33:1012-1024.
5. Costa M.A., Girard M., Dalmay F., Malauzat D. Brain-derived neurotrophic factor serum levels in alcohol-dependent subjects 6 months after alcohol withdrawal. Alcoholism: Clinical and Experimental Research 2011, 35:1966-1973.
6. Degos V., Charpentier T.L., Chhor V., Brissaud O., Lebon S., Schwendimann L., et al. Neuroprotective effects of dexmedetomidine against glutamateagonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology 2013, 118:1123-1132.
7. Heberlein A., Muschler M., Wilhelm J., Frieling H., Lenz B., Gröschl M., et al. BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal. Progress in Neuro-psychopharmacology & Biological Psychiatry 2010, 34:1060-1064.
8. Huang M.C., Chen C.H., Chen C.H., Liu S.C., Ho C.J., Shen W.W., et al. Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal. Alcohol and Alcoholism 2008, 43:241-245.
9. Huang T.L., Hung Y.Y. Lorazepam reduces the serum brain-derived neurotrophic factor level in schizophrenia patients with catatonia. Progress in Neuro-psychopharmacology & Biological Psychiatry 2009, 33:158-159.
10. Huopaniemi L., Keist R., Randolph A., Certa U., Rudolph U. Diazepam-induced adaptive plasticity revealed by alpha1 GABAA receptor-specific expression profiling. Journal of Neurochemistry 2004, 88:1059-1067.
11. Jeanblanc J., He D.Y., Carnicella S., Kharazia V., Janak P.H., Ron D. Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. The Journal of Neuroscience 2009, 29:13494-13502.
12. Jung M.E., Metzger D.B. Alcohol withdrawal and brain injuries: beyond classical mechanisms. Molecules 2010, 15:4984-5011.
13. Juric D.M., Loncar D., Carman-Krzan M. Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1- and beta1/beta2-adrenergic receptors. Neurochemistry International 2008, 52:297-306.
14. Karagülle D., Heberlein A., Wilhelm J., Frieling H., Kornhuber J., Bleich S., et al. Biological markers for alcohol withdrawal seizures: a retrospective analysis. European Addiction Research 2012, 18:97-102.
15. Köhler S., Klimke S., Hellweg R., Lang U.E. Serum brain-derived neurotrophic factor and nerve growth factor concentrations change after alcohol withdrawal: preliminary data of a case-control comparison. European Addiction Research 2013, 19:98-104.
16. Lewin G.R., Barde Y.A. Physiology of the neurotrophins. Annual Review of Neuroscience 1996, 19:289-317.
17. Logrip M.L., Janak P.H., Ron D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression. Journal of Neurochemistry 2009, 109:1459-1468.
18. Mueller S.W., Preslaski C.R., Kiser T.H., Fish D.N., Lavelle J.C., Malkoski S.P., et al. Arandomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal. Critical Care Medicine 2013, 42:1131-1139.
19. Preslaski C.R., Mueller S.W., Wempe M.F., MacLaren R. Stability of dexmedetomidine in polyvinyl chloride bags containing 0.9% sodium chloride injection. American Journal of Health-System Pharmacy 2013, 70:1336-1341.
20. Talke P., Richardson C.A., Scheinin M., Fisher D.M. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesthesia and Analgesia 1997, 85:1136-1142.
21. Ting-A-Kee R., Vargas-Perez H., Bufalino M.R., Bahi A., Dreyer J.L., Tyndale R.F., et al. Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. The European Journal of Neuroscience 2013, 37:996-1003.
22. Vutskits L., Lysakowski C., Czarnetzki C., Jenny B., Copin J.C., Tramèr M.R. Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial. Neurochemical Research 2008, 33:1325-1331.
23. Yan M., Dai H., Ding T., Dai A., Zhang F., Yu L., et al. Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochemistry International 2011, 58:549-557.
24. Yang L., Xu J.M., Jiang X., Ruan W., Cui Y., He L. Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: a double-blind, randomized and placebo-controlled study. Upsala Journal of Medical Sciences 2013, 118:235-239.