High frequency of Merkel cell polyomavirus DNA in the urine of kidney transplant recipients and healthy controls

Journal of Clinical Virology

Volumn 61, Issue 4, 2014, Pages 565-570

  Signorini, Lucia ^a   Belingheri, Mirco ^b   Ambrogi, Federico ^a   Pagani, Elisabetta ^c   Binda, Sandro ^d   Ticozzi, Rosalia ^a   Ferraresso, Mariano ^a   Ghio, Luciana ^b   Giacon, Bruno ^e   Ferrante, Pasquale ^a,f   Delbue, Serena ^a,g  

^a UNIVERSITY OF MILAN   (Italy)

^b Clinica Pediatrica De Marchi   (Italy)

^c Azienda Sanitaria dell'Alto Adige   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e Nephrology and Dialysis Unit Comprensorio Sanitario di Bolzano Azienda Sanitaria dell'Alto Adige   (Italy)

^f Health Science Foundation   (Italy)

^g ISTITUTO CLINICO CITTÀ STUDI   (Italy)

Author keywords

Kidney transplant recipients; Merkel cell polyomavirus; Polyomaviruses; Urinary excretion

Indexed keywords

DEOXYRIBONUCLEASE I; GENOMIC DNA; VIRUS DNA;

ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GRAFT RECIPIENT; HUMAN; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; MERKEL CELL POLYOMAVIRUS; MOLECULAR DIAGNOSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; URINALYSIS; URINARY EXCRETION; VIRUS LOAD; VIRUS REACTIVATION; VIRUS STRAIN; ADOLESCENT; AGED; GENETICS; INFANT; ISOLATION AND PURIFICATION; KIDNEY TRANSPLANTATION; MIDDLE AGED; NORMAL HUMAN; POLYOMAVIRUS; PRESCHOOL CHILD; URINE; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; FEMALE; HEALTHY VOLUNTEERS; HUMANS; INFANT; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POLYOMAVIRUS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSPLANT RECIPIENTS; URINE; VIRAL LOAD; YOUNG ADULT;

EID: 84922647746     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2014.10.012     Document Type: Article

References (26)

1. Kean J.M., Rao S., Wang M., Garcea R.L. Seroepidemiology of human Polyomaviruses. PLoS Pathog 2009, 5(3). article ID: e1000363.
2. White M.K., Gordon J., Khalili K. The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology. PLoS Pathog 2013, 9(March (3)):e1003206.
3. Drachenberg C.B., Hirsch H.H., Papadimitriou J.C., Gosert R., Wali R.K., Munivenkatappa R., et al. Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. Transplantation 2007, 84(August (3)):323-330.
4. Delbue S., Ferraresso M., Ghio L., Carloni C., Carluccio S., Belingheri M., et al. A review on JC virus infection in kidney transplant recipients. Clin Dev Immunol 2013, 2013:926391.
5. Polo C., Pérez J.L., Mielnichuck A., Fedele C.G., Niubò J., Tenorio A. Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children. Clin Microbiol Infect 2004, 10:640-644.
6. Kantola K., Sadeghi M., Lahtinen A., Koskenvuo M., Aaltonen L.M., Möttönen M., et al. Merkel cell polyomavirus DNA in tumor-free tonsillar tissues and upper respiratory tract samples: implications for respiratory transmission and latency. J Clin Virol 2009, 45(August (4)):292-295.
7. Feng H., Shuda M., Chang Y., Moore P.S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008, 319(5866):1096-1100.
8. Hussein M.I., Anastasi B., Singer J., Lacey S.F. A comparative study of Merkel cell, BK and JC polyomavirus infections in renal transplant recipients and healthy subjects. J Clin Virol 2010, 49(2):137-140.
9. Mertz K.D., Junt T., Schmid M., Pfaltz M., Kempf W. Inflammatory monocytes are a reservoir for Merkel cell polyomavirus. J Investig Dermatol 2010, 130(April (4)):1146-1151.
10. Rianthavorn P., Posuwan N., Payungporn S., Theamboonlers A., Poovorawan Y. Polyomavirus reactivation in pediatric patients with systemic lupus erythematosus. Tohoku J Exp Med 2012, 228(3):197-204.
11. Bofill-Mas S., Rodriguez-Manzano J., Calgua B., Carratala A., Girones R. Newly described human polyomaviruses Merkel cell, KI and WU are present in urban sewage and may represent potential environmental contaminants. Virol J 2010, 7(June):141.
12. Delbue S., Tremolada S., Elia F., Carloni C., Amico S., Tavazzi E., et al. Lymphotropic polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects. J Clin Virol 2010, 47(February (2)):156-160.
13. Goh S., Lindau C., Tiveljung-Lindell A., Allander T. Merkel cell polyomavirus in respiratory tract secretions. Emerg Infect Dis 2009, 15:489-491.
14. Delbue S., Ferraresso M., Elia F., Belingheri M., Carloni C., Signorini L., et al. Investigation of polyomaviruses replication in pediatric patients with nephropathy receiving rituximab. J Med Virol 2012, 84(9):1464-1470.
15. Agostini H.T., Ryschkewitsch C.F., Stoner G.L. Genotype profile of human polyomavirus JC excreted in urine of immunocompetent individuals. J Clin Microbiol 1996, 34:159-164.
16. Ault G.S., Stoner G.L. Human polyomavirus JC promoter/enhancer rearrangement patterns from progressive multifocal leukoencephalopathy brain are unique derivatives of a single archetypal structure. J Gen Virol 1993, 74:1499-1507.
17. Jensen P.N., Major E.O. Review. A classification scheme for human polyomavirus JCV variants based on the nucleotide sequence of the noncoding regulatory region. J Neurovirol 2001, 7:280-287.
18. Jin L., Gibson P.E., Knowles W.A., Clewley J.P. BK virus antigenic variants: sequence analysis within the capsid VP1 epitope. J Med Virol 1993, 39:50-56.
19. R Core Team R: a language and environment for statisticalcomputing 2014, R Foundation for Statistical Computing, Vienna, Austria, http://www. R-project.org/.
20. Zhong S., Zheng H.Y., Suzuki M., Chen Q., Ikegaya H., Aoki N., et al. Age-related urinary excretion of BK polyomavirus by nonimmunocompromised individuals. J Clin Microbiol 2007, 45(1):193-198.
21. Pires E.P., Bernardino-Vallinoto C.V., Alves D.M., Migone S.R., Machado L.F., Ishak M.O., et al. Prevalence of infection by JC and BK polyomaviruses in kidney transplant recipients and patients with chronic renal disease. Transpl Infect Dis 2011, 13(6):633-637.
22. Martel-Jantin C., Pedergnana V., Nicol J.T., Leblond V., Trégouët D.A., Tortevoye P., et al. Merkel cell Polyomavirus infection occurs during early childhood and is transmitted between siblings. J Clin Virol 2013, 58(September (1)):288-291.
23. Kumar A., Chen T., Pakkanen S., Kantele A., Söderlund-Venermo M., Hedman K., et al. T-helper cell-mediated proliferation and cytokine responses against recombinant Merkel cell polyomavirus-like particles. PLoS ONE 2011, 6:e25751.
24. van der Meijden E., Bialasiewicz S., Rockett R.J., Tozer S.J., Sloots T.P., Feltkamp M.C. Different serologic behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 polyomaviruses found on the skin. PLOS ONE 2013, 8(November (11)):e81078.
25. Laude H.C., Jonchère B., Maubec E., Carlotti A., Marinho E., Couturaud B., et al. Distinct Merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma. PLoS Pathog 2010, 6(August (8)):e1001076.
26. van der Meijden E., Wunderink H.F., van der Blij-de Brouwer C.S., Zaaijer H.L., Rotmans J.I., Bavinck J.N., et al. Human polyomavirus 9 infection in kidney transplant patients. Emerg Infect Dis 2014, 20(6):991-999.