Phenylthiocarbamide taste sensitivity is associated with sinonasal symptoms in healthy adults

International Forum of Allergy and Rhinology

Volumn 5, Issue 2, 2015, Pages 111-118

  Farquhar, Douglas R ^a   Kovatch, Kevin J ^a   Palmer, James N ^a   Shofer, Frances S ^a   Adappa, Nithin D ^a   Cohen, Noam A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Allergy; Bitter taste receptor; Quality of life; Rhinitis; Sinusitis; T2R gene; T2R38

Indexed keywords

PHENYLTHIOUREA; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

ADULT; ALLERGY; ARTICLE; ASTHMA; BITTER TASTE; COMMON COLD; COMORBIDITY; EAR INFECTION; FEMALE; HEALTH SURVEY; HUMAN; HUMAN EXPERIMENT; MALE; MIDDLE AGED; NORMAL HUMAN; NOSE ALLERGY; PARANASAL SINUS; PARANASAL SINUSITIS; PRIORITY JOURNAL; QUALITY OF LIFE; RECEPTOR SENSITIVITY; SEX DIFFERENCE; TASTE ACUITY; TASTE BUD; TONGUE; YOUNG ADULT; ADOLESCENT; AGED; DIAGNOSTIC USE; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT INFECTIONS; RHINITIS; SINUSITIS; TASTE;

ADOLESCENT; ADULT; AGED; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; PHENYLTHIOUREA; QUALITY OF LIFE; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATORY TRACT INFECTIONS; RHINITIS; SINUSITIS; TASTE; YOUNG ADULT;

EID: 84922628354     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21437     Document Type: Article

References (16)

1. Nathan RA, Meltzer EO, Derebery J, et al. The prevalence of nasal symptoms attributed to allergies in the United States: findings from the burden of rhinitis in an America survey. Allergy Asthma Proc. 2008;29:600-608.
2. Schappert SM. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1996. Vital Health Stat 13. 1998;134:1-37.
3. Pleis JR, Lucas JW, Ward BW. Summary health statistics for U.S. adults: National Health Interview Survey, 2008. Vital Health Stat 10. 2009;242:1-157.
4. Bhattacharyya N. Incremental health care utilization and expenditures for chronic rhinosinusitis in the United States. Ann Otol Rhinol Laryngol. 2011;120:423-427.
5. Braun T, Mack B, Kramer MF. Solitary chemosensory cells in the respiratory and vomeronasal epithelium of the human nose: a pilot study. Rhinology. 2011;49:507-512.
6. Shah AS, Ben-Shahar Y, Moninger TO, Kline JN, Welsh MJ. Motile cilia of human airway epithelia are chemosensory. Science. 2009;325:1131-1134.
7. Tizzano M, Cristofoletti M, Sbarbati A, Finger TE. Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med. 2011;11:3.
8. Cohen M, Kofonow J, Nayak JV, et al. Biofilms in chronic rhinosinusitis: a review. Am J Rhinol Allergy. 2009;23:255-260.
9. Suh JD, Cohen NA, Palmer JN. Biofilms in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2010;18:27-31.
10. Lee RJ, Xiong G, Kofonow JM, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest. 2012;122:4145-4159.
11. Reed DR, Knaapila A. Genetics of taste and smell: poisons and pleasures. Prog Mol Biol Transl Sci. 2010;94:213-240.
12. Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiology Behavior. 1994;56:1165-1171.
13. Adappa ND, Howland TJ, Palmer JN, et al. Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention. Int Forum Allergy Rhinol. 2013;3:184-187.
14. Adappa ND, Adappa ND, Zhang Z, et al. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol. 2014;4:3-7.
15. Verma P, Shetty V, Hegde AM. Propylthiouracil (PROP)-a tool to determine taster status in relation to caries experience, Streptococcus mutans levels and dietary preferences in children. J Clin Pediatr Dent. 2006;31:113-117.
16. Bufe B, Breslin PAS, Kuhn C, et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 2005;15:322-327.