Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, Quantification, and Measurement of Biological Activities In Vitro and In Vivo

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Kitamura, Seiya ^a   Morisseau, Christophe ^a   Inceoglu, Bora ^a   Kamita, Shizuo G ^a   De Nicola, Gina R ^b   Nyegue, Maximilienne ^c   Hammock, Bruce D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 (4 METHOXYBENZYL)UREA; 1,3 BIS(4 METHOXYBENZYL)UREA; 1,3 DIBENZYLUREA; ANALGESIC AGENT; EPOXIDE HYDROLASE; PENTADIPLANDRA BRAZZEANA EXTRACT; PLANT EXTRACT; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; UREA; ENZYME INHIBITOR; EPHX2 PROTEIN, HUMAN; EPHX2 PROTEIN, RAT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; IC50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY PAIN; LIQUID CHROMATOGRAPH; MALE; MASS SPECTROMETRY; MEDICINAL PLANT; NOCICEPTION; NONHUMAN; PENTADIPLANDRA BRAZZEANA; PLANT ROOT; QUANTITATIVE ASSAY; RAT; ANALGESIA; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DISEASE MODEL; ENZYMOLOGY; HUMAN; ISOLATION AND PURIFICATION; NOCICEPTIVE PAIN; ROSALES;

PENTADIPLANDRA BRAZZEANA; RATTUS;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; NOCICEPTIVE PAIN; PAIN MANAGEMENT; PLANT ROOTS; RATS; ROSALES;

EID: 84922572660     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117438     Document Type: Article

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