Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: A blinded interventional pilot study

British Journal of Anaesthesia

Volumn 114, Issue 2, 2015, Pages 244-251

  West, M A ^a,b   Loughney, L ^a,c   Lythgoe, D ^d   Barben, C P ^a   Sripadam, R ^e   Kemp, G J ^b   Grocott, M P W ^a,b,c,f,g   Jack, S ^a,b,c,f,g  

^a ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e CLATTERBRIDGE CENTRE FOR ONCOLOGY   (United Kingdom)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^g University Hospital Southampton NHS Foundation Trust   (United Kingdom)

Author keywords

anaerobic threshold; cardiopulmonary exercise test; exercise; prehabilitation; rectal cancer; surgery

Indexed keywords

CAPECITABINE; HEMOGLOBIN; LACTIC ACID;

ADJUVANT CHEMORADIOTHERAPY; ADULT; AGED; ARTICLE; CANCER MORTALITY; CARDIOPULMONARY EXERCISE TEST; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; FEASIBILITY STUDY; FEMALE; FITNESS; FOLLOW UP; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GAS EXCHANGE; HUMAN; MALE; MORBIDITY; MULTIMODALITY CANCER THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PILOT STUDY; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECTUM CANCER; ADJUVANT THERAPY; ANAEROBIC THRESHOLD; CLINICAL TRIAL; EXERCISE TEST; MIDDLE AGED; MORTALITY; MOTOR ACTIVITY; PHYSICAL EDUCATION; PHYSIOLOGY; PREOPERATIVE CARE; PROCEDURES; RECTAL NEOPLASMS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANAEROBIC THRESHOLD; COHORT STUDIES; EXERCISE TEST; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; NEOADJUVANT THERAPY; PHYSICAL EDUCATION AND TRAINING; PHYSICAL FITNESS; PILOT PROJECTS; PREOPERATIVE CARE; RECTAL NEOPLASMS;

EID: 84922561350     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu318     Document Type: Article

References (40)

1. Statistical Bulletin Cancer registrations in England, 2010
2. Statistical Bulletin Cancer Incidence and Mortality in the United Kingdom, 2008-10
3. Finan P, Greenaway K. National Bowel Cancer Audit, 2012
4. Habr-Gama A, Perez RO, Nadalin W, et al. Operative versus nonoperative treatment for Stage 0 distal rectal cancer following chemoradiation therapy. Ann Surg 2004; 240: 711-8
5. Chau I, Brown G, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 2006; 24: 668-74
6. Mohiuddin M, Winter K, Mitchell E, et al. Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012. J Clin Oncol 2006; 24: 650-5
7. Bosset JF, Collette L, Calais G, et al.Chemotherapywith preoperative radiotherapy in rectal cancer. N Engl J Med 2006; 355: 1114-23
8. Gérard JP, Conroy T, Bonnetain F, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006; 24: 4620-5
9. Swellengrebel HAM, Marijnen CAM, Verwaal VJ, et al. Toxicity and complications of preoperative chemoradiotherapy for locally advanced rectal cancer. Br J Surg 2011; 98: 418-26
10. Marijen C, Kapiteijn E, vab de Velde C, et al. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a mulitcenter randomized trial. J Clin Oncol 2002; 20: 817-25
11. Kehlet H. Manipulation of the metabolic response in clinical practice. World J Surg 2000; 24: 690-5
12. Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg 2002; 183: 630-41
13. Ditmyer N, Topp R, Pifer M. Prehabilitation in preparation for orthopaedic surgery. Orthop Nurs 2002; 21: 43-51
14. Carli F, Charlebois P, Stein B, et al. Randomized clinical trial of prehabilitation in colorectal surgery. Br J Surg 2010; 97: 1187-97
15. Singh F, Newton R, GalvaoD, Spry N, Baker M.A systematic reviewof pre-surgical exercise intervention studies with cancer patients. Surg Oncol 2013; 22: 92-104
16. DohertyAFO, WestM, Jack S, GrocottMPW. Preoperative aerobic exercise training in elective intra-cavity surgery: a systematic review. Br J Anaesth 2013; 110: 679-89
17. Lai CW, Minto G, Challand CP, et al. Patients inability to perform a preoperative cardiopulmonary exercise test or demonstrate an anaerobic threshold is associated with inferior outcomes after major colorectal surgery. Br J Anaesth 2013; 111: 607-11
18. WilsonRJT, DaviesS, YatesD, RedmanJ, StoneM.Impairedfunctional capacity is associated with all-cause mortality after major elective intra-abdominal surgery. Br J Anaesth 2010; 105: 297-303
19. Snowden CP, Prentis J, Jacques B, et al. Cardiorespiratory fitness predicts mortality and hospital length of stay after major elective surgery in older people. Ann Surg 2013; 257: 999-1004
20. West M, Jack S, Grocott MPW. Perioperative cardiopulmonary exercise testing in the elderly. Best Pract Res Clin Anaesthesiol 2011; 25: 427-37
21. Carlisle J, Swart M. Mid-term survival after abdominal aortic aneurysm surgery predicted by cardiopulmonary exercise testing. Br J Surg 2007; 94: 966-9
22. Silver JK, Baima J. Cancer prehabilitation: an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil 2013; 92: 715-27
23. Sobin LH, Fleming ID. TNM classification of malignant tumors. Cancer 1997; 80: 1803-4
24. Oken MM, Creech RH, Tormey DC, et al. Toxicityand response criteria of the Eastern Cooperative Oncology Group.AmJ Clin Oncol 1982;5: 649-55
25. RostonW, Whipp B, Davis J, CunninghamD, Effros R, Wasserman K. Oxygen uptake kinetics and lactate concentration during exercise in humans. Am Rev Respir Dis 1987; 135: 1080-4
26. MacFarlane JK, Ryall RDH, Heald RJ. Mesorectal excision for rectal cancer. Lancet 1993; 341: 457-60
27. West MA, Lythgoe D, Barben C, et al. Cardiopulmonary exercise variables are associated with postoperative morbidity after major colonic surgery: a prospective blinded observational study. Br J Anaesth 2014; 112: 665-71
28. BromageSJ, CunliffeWJ.Validation of the CR-POSSUMrisk-adjusted scoring system for major colorectal cancer surgery in a single center. Dis Colon Rectum 2007; 50: 192-6
29. West MA, Jack S, Kemp G, Barben C, Grocott M. The effect of neoadjuvant chemoradiotherapy on fitness in patients undergoing rectal cancer surgery-fitfor surgery?AmJRespir CritCareMed2012;185: A6395
30. Hennis PJ, MealePM, GrocottMPW.Cardiopulmonaryexercisetesting for the evaluation of perioperative risk in non-cardiopulmonary surgery. Postgrad Med J 2011; 87: 550-7
31. Smith TB, Stonell C, Purkayastha S, Paraskevas P. Cardiopulmonary exercise testing as a risk assessment method in non cardiopulmonary surgery: a systematic review. Anaesthesia 2009; 64: 883-93
32. Piepoli MF, Davos C, Francis DP, Coats AJS. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). Br Med J 2004; 328: 189
33. Riario-Sforza GG, Incorvaia C, Paterniti F, et al. Effects of pulmonary rehabilitation on exercise capacity in patients with COPD: a number needed to treat study. Int J Chron Obstruct Pulmon Dis 2009; 4: 315-9
34. Sandercock G, Hurtado V, Cardoso F. Changes in cardiorespiratory fitness in cardiac rehabilitation patients: a meta-analysis. Int J Cardiol 2013; 167: 894-902
35. Li C, Carli F, Lee L, et al. Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study. Surg Endosc 2013; 27: 1072-82
36. Kim DJ, Mayo NE, Carli F, Montgomery DL, Zavorsky GS. Responsive measures to prehabilitation in patients undergoing bowel resection surgery. Tohoku J Exp Med 2009; 217: 109-15
37. Dronkers JJ, LambertsH, ReutelingspergerIMMD, et al. Preoperative therapeutic programme for elderly patients scheduled for elective abdominal oncological surgery: a randomized controlled pilot study. Clin Rehabil 2010; 24: 614-22
38. Kothmann E, Batterham AM, Owen SJ, et al. Effect of short-term exercise training on aerobic fitness in patients with abdominal aortic aneurysms: a pilot study. Br J Anaesth 2009; 103: 505-10
39. Choi BCK, Pak AWP, Choi JCL, Choi ECL. Daily step goal of 10, 000 steps: a literature review. Clin Invest Med 2007; 30: 146-51
40. Snowden CP, Prentis JM, Anderson HL, et al. Submaximal cardiopulmonary exercise testing predicts complications and hospital length of stay in patients undergoing major elective surgery. Ann Surg 2010; 251: 535-41