Tomography of epidermal growth factor receptor binding to fluorescent Affibody in vivo studied with magnetic resonance guided fluorescence recovery in varying orthotopic glioma sizes

Journal of Biomedical Optics

Volumn 20, Issue 2, 2015, Pages

  Holt, Robert W ^a   Demers, Jennifer Lynn H ^b   Sexton, Kristian J ^b   Gunn, Jason R ^b   Davis, Scott C ^b   Samkoe, Kimberley S ^b,c   Pogue, Brian W ^a,b,c  

^a Lamont Doherty Earth Observatory   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

diffuse; diffuse optical tomography; fluorescence molecular tomography; magnetic resonance imaging; molecular; reconstruction; tomography

Indexed keywords

BINDING ENERGY; FLUORESCENCE; IMAGE RECONSTRUCTION; MAGNETIC RESONANCE IMAGING; OPTICAL TOMOGRAPHY; TOMOGRAPHY;

DIFFUSE; DIFFUSE OPTICAL TOMOGRAPHY; EPIDERMAL GROWTH FACTOR RECEPTORS; FLUORESCENCE MOLECULAR TOMOGRAPHY; MOLECULAR; PHARMACOKINETIC PROPERTIES; SPATIAL HETEROGENEITY; TOMOGRAPHIC TECHNIQUES;

TUMORS;

EPIDERMAL GROWTH FACTOR RECEPTOR; FLUORESCENT DYE; HYBRID PROTEIN; PROTEIN BINDING;

ANIMAL; BRAIN CHEMISTRY; BRAIN TUMOR; CHEMISTRY; GLIOMA; HEAD; HUMAN; IMAGE PROCESSING; METABOLISM; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; OPTICAL TOMOGRAPHY; PATHOLOGY; PROCEDURES; TUMOR CELL LINE;

ANIMALS; BRAIN CHEMISTRY; BRAIN NEOPLASMS; CELL LINE, TUMOR; FLUORESCENT DYES; GLIOMA; HEAD; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; TOMOGRAPHY, OPTICAL;

EID: 84922553497     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.20.2.026001     Document Type: Article

References (19)

1. K. M. Tichauer et al., "Advantages of a dual-tracer model over reference tissue models for binding potential measurement in tumors," Phys. Med. Biol. 57(20), 6647-6659 (2012).
2. K. M. Tichauer et al., "Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging," J. Biomed. Opt. 17(6), 066001 (2012).
3. S. C. Davis et al., "Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo," Proc. Natl. Acad. Sci. U S A 110(22), 9025-9030 (2013).
4. K. M. Tichauer et al., "Dual-tracer background subtraction approach for fluorescent molecular tomography," J. Biomed. Opt. 18(1), 016003 (2013).
5. M. A. Mintun et al., "A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography," Ann. Neurol. 15(3), 217-227 (1984).
6. M. Laruelle, M. Slifstein, and Y. Huang, "Positron emission tomography: imaging and quantification of neurotransporter availability," Methods 27(3), 287-299 (2002).
7. A. A. Lammertsma and S. P. Hume, "Simplified reference tissue model for PET receptor studies," Neuroimage 4(3), 153-158 (1996).
8. R. B. Innis et al., "Consensus nomenclature for in vivo imaging of reversibly binding radioligands," J. Cereb. Blood Flow Metab. 27(9), 1533-1539 (2007).
9. K. M. Tichauer et al., "In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging," Mol. Imaging Biol. 14(5), 584-592 (2012).
10. K. S. Samkoe et al., "High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas," Mol. Imaging Biol. 14(4), 472-479 (2012).
11. A. K. Liu, M. E. Macy, and N. K. Foreman, "Bevacizumab as therapy for radiation necrosis in four children with pontine gliomas," Int. J. Radiat. Oncol. Biol. Phys. 75(4), 1148-1154 (2009).
12. M. Ichise et al., "Strategies to improve neuroreceptor parameter estimation by linear regression analysis," J. Cereb. Blood Flow Metab. 22(10), 1271-1281 (2002).
13. S. C. Davis et al., "Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue," Rev. Sci. Instrum. 79(6), 064302 (2008).
14. S. C. Davis et al., "Comparing implementations of magnetic-resonanceguided fluorescence molecular tomography for diagnostic classification of brain tumors," J. Biomed. Opt. 15(5), 051602 (2010).
15. K. M. Tichauer et al., "Computed tomography-guided time-domain diffuse fluorescence tomography in small animals for localization of cancer biomarkers," J. Vis. Exp. 17(65), e4050 (2012).
16. K. S. Samkoe et al., "Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced MR image contrast but has higher positive predictive value," J. Biomed. Opt. 16(9), 096008 (2011).
17. K. Sexton et al., "Fluorescent Affibody peptide penetration in glioma margin is superior to full antibody," PLoS One 8(4), e60390 (2013).
18. M. Jermyn et al., "Fast segmentation and high-quality three-dimensional volume mesh creation from medical images for diffuse optical tomography," J. Biomed. Opt. 18(8), 086007 (2013).
19. www.nirfast.org.