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Volumn 8, Issue 4, 2015, Pages 463-480

Association between maternal MTHFR polymorphisms and nonsyndromic cleft lip with or without cleft palate in offspring, a meta-analysis based on 15 case-control studies

Author keywords

Cleft lip; Meta analysis; Methylenetetrahydrofolate reductase

Indexed keywords

METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

EID: 84922548794     PISSN: 2008076X     EISSN: 20080778     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (28)

References (53)
  • 1
    • 43649083220 scopus 로고    scopus 로고
    • Genetic Factors and Orofacial Clefting
    • Lidral AC, Moreno LM, Bullard SA. Genetic Factors and Orofacial Clefting. Semin Orthod. 2008; 14(2): 103-114
    • (2008) Semin Orthod , vol.14 , Issue.2 , pp. 103-114
    • Lidral, A.C.1    Moreno, L.M.2    Bullard, S.A.3
  • 2
    • 1642383053 scopus 로고    scopus 로고
    • The complex genetics of cleft lip and palate
    • Cobourne MT. The complex genetics of cleft lip and palate. Eur J Orthod. 2004; 26(1): 7-16
    • (2004) Eur J Orthod , vol.26 , Issue.1 , pp. 7-16
    • Cobourne, M.T.1
  • 3
    • 84922562029 scopus 로고    scopus 로고
    • Study on genetic locus of non-syndromic cleft lip with or without cleft palate
    • (in Chinese)
    • Sun H, Huang H. Study on genetic locus of non-syndromic cleft lip with or without cleft palate. International Journal of Oral Medicine Volume. 2000; 27(2): 100-103. (in Chinese)
    • (2000) International Journal of Oral Medicine Volume , vol.27 , Issue.2 , pp. 100-103
    • Sun, H.1    Huang, H.2
  • 5
    • 70349097584 scopus 로고    scopus 로고
    • The genetics of isolated orofacial clefts: From genotypes to subphenotypes
    • Jugessur A, Farlie PG, Kilpatrick N. The genetics of isolated orofacial clefts: From genotypes to subphenotypes. Oral Dis. 2009; 15(7): 437-453
    • (2009) Oral Dis , vol.15 , Issue.7 , pp. 437-453
    • Jugessur, A.1    Farlie, P.G.2    Kilpatrick, N.3
  • 7
    • 0242600545 scopus 로고    scopus 로고
    • Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate?
    • Van Rooij IA, Vermeij-Keers C, Kluijtmans LA, Ocke MC, Zielhuis GA, Goorhuis-Brouwer SM, et al. Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate?. Am J Epidemiol. 2003; 157(7): 583-591
    • (2003) Am J Epidemiol , vol.157 , Issue.7 , pp. 583-591
    • Van Rooij, I.A.1    Vermeij-Keers, C.2    Kluijtmans, L.A.3    Ocke, M.C.4    Zielhuis, G.A.5    Goorhuis-Brouwer, S.M.6
  • 9
    • 33847786727 scopus 로고    scopus 로고
    • Folic acid supplements and risk of facial clefts: National population based case-control study
    • Wilcox AJ, Lie RT, Solvoll K, Taylor J, McConnaughey DR, Abyholm F, et al. Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ. 2007; 334(7591): 464
    • (2007) BMJ , vol.334 , Issue.7591 , pp. 464
    • Wilcox, A.J.1    Lie, R.T.2    Solvoll, K.3    Taylor, J.4    McConnaughey, D.R.5    Abyholm, F.6
  • 10
    • 53449091417 scopus 로고    scopus 로고
    • Folate intake, markers of folate status and oral clefts: Is the evidence converging?
    • Johnson CY, Little J. Folate intake, markers of folate status and oral clefts: is the evidence converging?. Int J Epidemiol. 2008; 37(5): 1041-1058
    • (2008) Int J Epidemiol , vol.37 , Issue.5 , pp. 1041-1058
    • Johnson, C.Y.1    Little, J.2
  • 11
    • 4043169859 scopus 로고    scopus 로고
    • Maternal MTHFR interacts with the offspring’s BCL3 genotypes, but not with TGFA, in increasing risk to non-syndromic cleft lip with or without cleft palate
    • Gaspar DA, Matioli SR, de Cassia Pavanello R, Araujo BC, Alonso N, Wyszynski D, et al. Maternal MTHFR interacts with the offspring’s BCL3 genotypes, but not with TGFA, in increasing risk to non-syndromic cleft lip with or without cleft palate. Eur J Hum Genet. 2004; 12(7): 521-526
    • (2004) Eur J Hum Genet , vol.12 , Issue.7 , pp. 521-526
    • Gaspar, D.A.1    Matioli, S.R.2    De Cassia Pavanello, R.3    Araujo, B.C.4    Alonso, N.5    Wyszynski, D.6
  • 12
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995; 10(1): 111-113
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 14
    • 0030955502 scopus 로고    scopus 로고
    • Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations
    • Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, et al. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet. 1997; 349(9065): 1591-1593
    • (1997) Lancet , vol.349 , Issue.9065 , pp. 1591-1593
    • Molloy, A.M.1    Daly, S.2    Mills, J.L.3    Kirke, P.N.4    Whitehead, A.S.5    Ramsbottom, D.6
  • 15
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
    • Van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet. 1998; 62(5): 1044-1051
    • (1998) Am J Hum Genet , vol.62 , Issue.5 , pp. 1044-1051
    • Van Der Put, N.M.1    Gabreels, F.2    Stevens, E.M.3    Smeitink, J.A.4    Trijbels, F.J.5    Eskes, T.K.6
  • 16
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998; 64(3): 169-172
    • (1998) Mol Genet Metab , vol.64 , Issue.3 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 17
    • 33646449190 scopus 로고    scopus 로고
    • MTHFR C677T and A1298C polymorphisms are risk factors for Down’s syndrome in Indian mothers
    • Rai AK, Singh S, Mehta S, Kumar A, Pandey LK, Raman R. MTHFR C677T and A1298C polymorphisms are risk factors for Down’s syndrome in Indian mothers. J Hum Genet. 2006; 51(4): 278-283
    • (2006) J Hum Genet , vol.51 , Issue.4 , pp. 278-283
    • Rai, A.K.1    Singh, S.2    Mehta, S.3    Kumar, A.4    Pandey, L.K.5    Raman, R.6
  • 18
    • 48649109174 scopus 로고    scopus 로고
    • Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C
    • Wan WD, Wang LJ, Zhou XP, Zhou DL, Zhang QG, Huang JL, et al. Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C. Zhonghua Zheng Xing Wai Ke Za Zhi. 2006; 22(1): 8-11
    • (2006) Zhonghua Zheng Xing Wai Ke Za Zhi , vol.22 , Issue.1 , pp. 8-11
    • Wan, W.D.1    Wang, L.J.2    Zhou, X.P.3    Zhou, D.L.4    Zhang, Q.G.5    Huang, J.L.6
  • 19
    • 67651034400 scopus 로고    scopus 로고
    • MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population
    • Ali A, Singh SK, Raman R. MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. Genet Test Mol Biomarkers. 2009; 13(3): 355-360
    • (2009) Genet Test Mol Biomarkers , vol.13 , Issue.3 , pp. 355-360
    • Ali, A.1    Singh, S.K.2    Raman, R.3
  • 20
    • 33644859355 scopus 로고    scopus 로고
    • Zhu H, et al.Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China
    • Zhu J, Ren A, Hao L, Pei L, Liu J, Zhu H, et al.Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China. Am J Med Genet A. 2006; 140(6): 551-557
    • (2006) Am J Med Genet A , vol.140 , Issue.6 , pp. 551-557
    • Zhu, J.1    Ren, A.2    Hao, L.3    Pei, L.4    Liu, J.5
  • 22
    • 79952118738 scopus 로고    scopus 로고
    • Relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate
    • Guo JZ, Song XM, Wang Y, Zhu WL, Li SQ, Li Y. Relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate. Beijing Da Xue Xue Bao. 2009; 41(4): 432-436
    • (2009) Beijing Da Xue Xue Bao , vol.41 , Issue.4 , pp. 432-436
    • Guo, J.Z.1    Song, X.M.2    Wang, Y.3    Zhu, W.L.4    Li, S.Q.5    Li, Y.6
  • 23
    • 65549155771 scopus 로고    scopus 로고
    • The common MTHFR C677T and A1298C variants are not associated with the risk of non-syndromic cleft lip/palate in northern Venezuela
    • Sozen MA, Tolarova MM, Spritz RA. The common MTHFR C677T and A1298C variants are not associated with the risk of non-syndromic cleft lip/palate in northern Venezuela. J Genet Genomics. 2009; 36(5): 283-288
    • (2009) J Genet Genomics , vol.36 , Issue.5 , pp. 283-288
    • Sozen, M.A.1    Tolarova, M.M.2    Spritz, R.A.3
  • 24
    • 0034686437 scopus 로고    scopus 로고
    • No evidence supporting MTHFR as a risk factorin the development of familial NSCLP
    • Blanton SH, Kolle BS, Hecht JT, Mulliken JB, Martin ER. No evidence supporting MTHFR as a risk factorin the development of familial NSCLP. Am J Med Genet. 2000; 92(5): 370-371
    • (2000) Am J Med Genet , vol.92 , Issue.5 , pp. 370-371
    • Blanton, S.H.1    Kolle, B.S.2    Hecht, J.T.3    Mulliken, J.B.4    Martin, E.R.5
  • 25
    • 80052113078 scopus 로고    scopus 로고
    • Allelic polymorphism of MTHFR, MTR and MTRR genes in patients with cleft lip and/or palate and their mothers
    • Chorna LB, Akopyan HR, Makukh HV, Fedoryk IM. Allelic polymorphism of MTHFR, MTR and MTRR genes in patients with cleft lip and/or palate and their mothers. Tsitol Genet. 2011; 45(3): 51-56
    • (2011) Tsitol Genet , vol.45 , Issue.3 , pp. 51-56
    • Chorna, L.B.1    Akopyan, H.R.2    Makukh, H.V.3    Fedoryk, I.M.4
  • 26
    • 82955187063 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and nonsyndromic orofacial clefts susceptibility in a southern Chinese population
    • Han Y, Pan Y, Du Y, Tong N, Wang M, Zhang Z, et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and nonsyndromic orofacial clefts susceptibility in a southern Chinese population. DNA Cell Biol. 2011; 30(12): 1063-1068
    • (2011) DNA Cell Biol , vol.30 , Issue.12 , pp. 1063-1068
    • Han, Y.1    Pan, Y.2    Du, Y.3    Tong, N.4    Wang, M.5    Zhang, Z.6
  • 27
    • 75449117469 scopus 로고    scopus 로고
    • TGFB3, and TGFA polymorphisms and their association with the risk of non-syndromic cleft lip and
    • Zhu J, Hao L, Li S, Bailey LB, Tian Y, Li Z. MTHFR, TGFB3, and TGFA polymorphisms and their association with the risk of non-syndromic cleft lip and cleft palate in China. Am J Med Genet A. 2010; 152A(2): 291-298
    • (2010) Am J Med Genet A , vol.152 , Issue.2 , pp. 291-298
    • Zhu, J.1    Hao, L.2    Li, S.3    Bailey, L.B.4    Tian, Y.5    Li, Z.6
  • 28
    • 0031785528 scopus 로고    scopus 로고
    • Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip
    • Shaw GM, Rozen R, Finnell RH, Todoroff K, Lammer EJ. Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip. Am J Med Genet. 1998; 80(3): 196-198
    • (1998) Am J Med Genet , vol.80 , Issue.3 , pp. 196-198
    • Shaw, G.M.1    Rozen, R.2    Finnell, R.H.3    Todoroff, K.4    Lammer, E.J.5
  • 29
    • 0038315197 scopus 로고    scopus 로고
    • Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads
    • Jugessur A, Wilcox AJ, Lie RT, Murray JC, Taylor JA, Ulvik A, et al. Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads. Am J Epidemiol. 2003; 157(12): 1083-1091
    • (2003) Am J Epidemiol , vol.157 , Issue.12 , pp. 1083-1091
    • Jugessur, A.1    Wilcox, A.J.2    Lie, R.T.3    Murray, J.C.4    Taylor, J.A.5    Ulvik, A.6
  • 31
    • 44649108372 scopus 로고    scopus 로고
    • Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe
    • Reutter H, Birnbaum S, Lacava AD, Mende M, Henschke H, Berge S, et al. Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe. Cleft Palate Craniofac J. 2008; 45(3): 267-271
    • (2008) Cleft Palate Craniofac J , vol.45 , Issue.3 , pp. 267-271
    • Reutter, H.1    Birnbaum, S.2    Lacava, A.D.3    Mende, M.4    Henschke, H.5    Berge, S.6
  • 33
    • 0042415793 scopus 로고    scopus 로고
    • Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip
    • Shotelersuk V, Ittiwut C, Siriwan P, Angspatt A. Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip. J Med Genet. 2003; 40(5): e64
    • (2003) J Med Genet , vol.40 , Issue.5 , pp. e64
    • Shotelersuk, V.1    Ittiwut, C.2    Siriwan, P.3    Angspatt, A.4
  • 34
    • 7244219970 scopus 로고    scopus 로고
    • Maternal MTHFR variant forms increase the risk in offspring of isolated non-syndromic cleft lip with or without cleft palate
    • Pezzetti F, Martinelli M, Scapoli L, Carinci F, Palmieri A, Marchesini J, et al. Maternal MTHFR variant forms increase the risk in offspring of isolated non-syndromic cleft lip with or without cleft palate. Hum Mutat. 2004; 24(1): 104-105
    • (2004) Hum Mutat , vol.24 , Issue.1 , pp. 104-105
    • Pezzetti, F.1    Martinelli, M.2    Scapoli, L.3    Carinci, F.4    Palmieri, A.5    Marchesini, J.6
  • 35
    • 84866746285 scopus 로고    scopus 로고
    • Association between parental MTHFR gene polymorphism 677C/T and nonsyndromic cleft lip and palate in offspring
    • Wang SM, Wang JH, Yu JC, Wei B, Wang KH, Liu JY, et al. Association between parental MTHFR gene polymorphism 677C/T and nonsyndromic cleft lip and palate in offspring. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012; 29(4): 464-467
    • (2012) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.29 , Issue.4 , pp. 464-467
    • Wang, S.M.1    Wang, J.H.2    Yu, J.C.3    Wei, B.4    Wang, K.H.5    Liu, J.Y.6
  • 38
    • 77949272183 scopus 로고    scopus 로고
    • The maternal homocysteine pathway is influenced by ri-boflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring
    • Vujkovic M, Steegers EA, van Meurs J, Yazdan-panah N, van Rooij IA, Uitterlinden AG, et al. The maternal homocysteine pathway is influenced by ri-boflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring. Eur J Clin Nutr. 2010; 64(3): 266-273
    • (2010) Eur J Clin Nutr , vol.64 , Issue.3 , pp. 266-273
    • Vujkovic, M.1    Steegers, E.A.2    Van Meurs, J.3    Yazdan-Panah, N.4    Van Rooij, I.A.5    Uitterlinden, A.G.6
  • 39
    • 33646765346 scopus 로고    scopus 로고
    • Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population
    • Mostowska A, Hozyasz KK, Jagodzinski PP. Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population. Clin Genet. 2006; 69(6): 512-517
    • (2006) Clin Genet , vol.69 , Issue.6 , pp. 512-517
    • Mostowska, A.1    Hozyasz, K.K.2    Jagodzinski, P.P.3
  • 40
    • 77955372062 scopus 로고    scopus 로고
    • Maternal genes and facial clefts in offspring: A comprehensive search for genetic associations in two population-based cleft studies from Scandinavia
    • Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, et al. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. PLoS One. 2010; 5(7): e11493
    • (2010) Plos One , vol.5 , Issue.7
    • Jugessur, A.1    Shi, M.2    Gjessing, H.K.3    Lie, R.T.4    Wilcox, A.J.5    Weinberg, C.R.6
  • 41
    • 84862780433 scopus 로고    scopus 로고
    • Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts
    • Shi M, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, et al. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. Am J Med Genet A. 2012; 158A(4): 784-794
    • (2012) Am J Med Genet A , vol.158 , Issue.4 , pp. 784-794
    • Shi, M.1    Murray, J.C.2    Marazita, M.L.3    Munger, R.G.4    Ruczinski, I.5    Hetmanski, J.B.6
  • 42
    • 84922559189 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase A1298C polymorphisms with non-syndromic cleft lip with or without cleft palate
    • Hu Y, Hou W, Chen EJ, Liu XH, Hou CL, Zhang XH. Association of methylenetetrahydrofolate reductase A1298C polymorphisms with non-syndromic cleft lip with or without cleft palate. Zhonghua Kou Qiang Yi Xue Za Zhi. 2011; 46(7): 394-397
    • (2011) Zhonghua Kou Qiang Yi Xue Za Zhi , vol.46 , Issue.7 , pp. 394-397
    • Hu, Y.1    Hou, W.2    Chen, E.J.3    Liu, X.H.4    Hou, C.L.5    Zhang, X.H.6
  • 43
    • 84865541363 scopus 로고    scopus 로고
    • Infants’ MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: A meta-analysis based on 17 case-control studies
    • Pan Y, Zhang W, Ma J, Du Y, Li D, Cai Q, et al. Infants’ MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case-control studies. Am J Med Genet A. 2012; 158A(9): 2162-2169
    • (2012) Am J Med Genet A , vol.158 , Issue.9 , pp. 2162-2169
    • Pan, Y.1    Zhang, W.2    Ma, J.3    Du, Y.4    Li, D.5    Cai, Q.6
  • 44
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414): 557-560
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 45
    • 48649107403 scopus 로고    scopus 로고
    • Folate and clefts of the lip and palate -a U.K.-based case-control study: Part II: Biochemical and genetic analysis
    • Little J, Gilmour M, Mossey PA, Fitzpatrick D, Cardy A, Clayton-Smith J, et al. Folate and clefts of the lip and palate -a U.K.-based case-control study: Part II: Biochemical and genetic analysis. Cleft Palate Craniofac J. 2008; 45(4): 428-438
    • (2008) Cleft Palate Craniofac J , vol.45 , Issue.4 , pp. 428-438
    • Little, J.1    Gilmour, M.2    Mossey, P.A.3    Fitzpatrick, D.4    Cardy, A.5    Clayton-Smith, J.6
  • 46
    • 0032751289 scopus 로고    scopus 로고
    • Role of the C677T polymorphism at the MTHFR gene on risk to non-syndromic cleft lip with/without cleft palate: Results from a case-control study in Brazil
    • Gaspar DA, Pavanello RC, Zatz M, Passos-Bueno MR, Andre M, Steman S, et al. Role of the C677T polymorphism at the MTHFR gene on risk to non-syndromic cleft lip with/without cleft palate: results from a case-control study in Brazil. Am J Med Genet. 1999; 87(2): 197-199
    • (1999) Am J Med Genet , vol.87 , Issue.2 , pp. 197-199
    • Gaspar, D.A.1    Pavanello, R.C.2    Zatz, M.3    Passos-Bueno, M.R.4    Re, M.5    Steman, S.6
  • 47
    • 0036096518 scopus 로고    scopus 로고
    • Maternal MTH-FR genotype contributes to the risk of non-syndromic cleft lip and palate
    • Prescott NJ, Winter RM, Malcolm S. Maternal MTH-FR genotype contributes to the risk of non-syndromic cleft lip and palate. J Med Genet. 2002; 39(5): 368-369
    • (2002) J Med Genet , vol.39 , Issue.5 , pp. 368-369
    • Prescott, N.J.1    Winter, R.M.2    Malcolm, S.3
  • 48
    • 0002106809 scopus 로고    scopus 로고
    • A common mutation in the MTHFR gene is a risk factor for non-syndromic cleft lip and palate anomalies
    • Tolarova MM, van Rooij IALM, Pastor M, Van der Put NMJ, Goldberg AC, Hol F, et al. A common mutation in the MTHFR gene is a risk factor for non-syndromic cleft lip and palate anomalies. Am J Hum Genet. 1998; 63: A27
    • (1998) Am J Hum Genet , vol.63 , pp. A27
    • Tolarova, M.M.1    Van Rooij, I.2    Pastor, M.3    Van Der Put, N.4    Goldberg, A.C.5    Hol, F.6
  • 49
    • 34247844422 scopus 로고    scopus 로고
    • Sayed-Tabatabaei F,Ursem N, Steegers E, Steegers-Theunissen R. Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: A meta-analysis
    • Verkleij-Hagoort A, Bliek J, Sayed-Tabatabaei F,Ursem N, Steegers E, Steegers-Theunissen R. Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis. Am J Med Genet A. 2007; 143A(9): 952-960
    • (2007) Am J Med Genet A , vol.143 , Issue.9 , pp. 952-960
    • Verkleij-Hagoort, A.1    Bliek, J.2
  • 51
    • 2942754073 scopus 로고    scopus 로고
    • Associations between maternal methylenetetrahy-drofolate reductase polymorphisms and adverse outcomes of pregnancy: The Hordaland Homocysteine Study
    • Nurk E, Tell GS, Refsum H, Ueland PM, Vollset SE. Associations between maternal methylenetetrahy-drofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study. Am J Med. 2004; 117(1): 26-31
    • (2004) Am J Med , vol.117 , Issue.1 , pp. 26-31
    • Nurk, E.1    Tell, G.S.2    Refsum, H.3    Ueland, P.M.4    Vollset, S.E.5
  • 52
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost. 1997; 78(1): 523-526
    • (1997) Thromb Haemost , vol.78 , Issue.1 , pp. 523-526
    • Rozen, R.1
  • 53
    • 0035067094 scopus 로고    scopus 로고
    • Ngo to neural tube defects (NTD) in a German populaET, Koch MC. Interaction of folate and homocysttion
    • Richter B, Stegmann K, Roper B, Boddeker I, Ngo to neural tube defects (NTD) in a German populaET, Koch MC. Interaction of folate and homocysttion. J Hum Genet. 2001; 46(3): 105-109
    • (2001) J Hum Genet , vol.46 , Issue.3 , pp. 105-109
    • Richter, B.1    Stegmann, K.2    Roper, B.3    Boddeker, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.