MGMT methylation in glioblastoma: Tale of the tail

Neuro-Oncology

Volumn 17, Issue 1, 2015, Pages 167-168

  Shah, Nameeta ^a   Schroeder, Brett ^a   Cobbs, Charles ^a  

^a SWEDISH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; ALKYLATING AGENT; DACARBAZINE; DNA LIGASE; DNA METHYLTRANSFERASE; MGMT PROTEIN, HUMAN; TEMOZOLOMIDE; TUMOR SUPPRESSOR PROTEIN;

CANCER SURVIVAL; GENE EXPRESSION; GLIOBLASTOMA; HEALTH CARE QUALITY; HUMAN; LETTER; PROGRESSION FREE SURVIVAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; TRANSCRIPTION INITIATION SITE; ANALOGS AND DERIVATIVES; DNA METHYLATION; GENETICS; KAPLAN MEIER METHOD; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS, ALKYLATING; DACARBAZINE; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; GLIOBLASTOMA; HUMANS; KAPLAN-MEIER ESTIMATE; PROMOTER REGIONS, GENETIC; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEINS;

EID: 84922536674     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou319     Document Type: Letter

References (5)

1. Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005; 352(10):997-1003.
2. Gilbert MR,Wang M, Aldape KD, et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol. 2013;31(32):4085-4091.
3. Shah N, Lin B, Sibenaller Z, et al. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM. PloS One. 2011;6(1):e16146.
4. Vlassenbroeck I, Califice S, Diserens AC, et al. Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma. J Mol Diagn. 2008;10(4):332-337.
5. Jeuken JW, Cornelissen SJ, Vriezen M, et al. MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas. Lab Invest. 2007;87(10):1055-1065.