Are we ready to incorporate sperm DNA-fragmentation testing into our male infertility work-up? A plea for more robust studies

Reproductive BioMedicine Online

Volumn 30, Issue 2, 2015, Pages 111-112

  Drobnis, Erma Z ^a   Johnson, Martin H ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT;

DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DNA FRAGMENTATION; EDITORIAL; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MALE; MALE FERTILITY; MALE INFERTILITY; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; SEMEN ANALYSIS; SENSITIVITY AND SPECIFICITY; INFERTILITY THERAPY; INFERTILITY, MALE; METABOLISM; SPERM; SPERMATOZOON;

DNA FRAGMENTATION; HUMANS; INFERTILITY, MALE; MALE; REPRODUCTIVE TECHNIQUES, ASSISTED; SEMEN; SPERMATOZOA;

EID: 84922518886     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2014.12.001     Document Type: Editorial

References (13)

1. ASRM Practice Committee, 2013. The clinical utility of sperm DNA integrity testing: a guideline. Fertil. Steril. 99, 673-677.
2. Barratt, L.R., Aitken, R.J., Björndahl, L., Carrell, D.T., de Boer, P., Kvist, U., Lewis, S.E.M., Perreault, S.D., Perry, M.J., Ramos, L., Robaire, B., Ward, S., Zini, A., 2010. Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications - a position report. Hum. Reprod. 25, 824-838.
3. Gunalp, S., Onculoglu, C., Gurgan, T., Kruger, T.F., Lombard, C.J., 2001. A study of semen parameters with emphasis on sperm morphology in a fertile population: an attempt to develop clinical thresholds. Hum. Reprod. 16, 110-114.
4. Kovac, J.R., Pastuszak, A.W., Lamb, D.J., 2013. The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility. Fertil. Steril. 99, 998-1007.
5. Menkveld, R., Wong, W.Y., Lombard, C.J., Wezels, A.M.M., Thomas, C.M.G., Merkus, H.M.W.M., Steegers-Theunissen, P.M., 2001. Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds. Hum. Reprod. 16, 1165-1171.
6. Oleszczuk, K., Augustinsson, L., Bayat, N., Giwercman, A., Bungum, M., 2013. Prevalence of high DNA fragmentation index in male partners of unexplained infertile couples. Andrology 1, 357-360.
7. Ombelet, W., Bosmans, E., Janssen, M., Cox, A., Vlasselaer, J., Gyselaers, W., Vandeput, H., Gielen, J., Pollet, H., Maes, M., Steeno, O., Kruger, T., 1997. Semen parameters in a fertile versus subfertile population: a need for change in the interpretation of semen testing. Hum. Reprod. 12, 987-993.
8. Osman, A., Alsomait, H., Seshadri, T., El-Toukhy, T., Khalaf, Y., 2015. The impact of sperm DNA fragmentation on live birth rate following IVF or ICSI: a systematic review and meta-analysis. Reprod. Biomed. Online (in press).
9. Ribas-Maynou, J., Garcia-Peiro, A., Fernandez-Encinas, A., Abad, C., Amengual, M.J., Prada, E., Navarro, J., Benet, J., 2013. Comprehensive analysis of sperm DNA fragmentation by five different assays: TUNEL assay, SCSA, SCD test and alkaline and neutral Comet assay. Andrology 1, 715-722.
10. Sergerie, M., Laforest, G., Bujan, L., Bissonnette, F., Bleau, G., 2005. Sperm DNA fragmentation: threshold value in male fertility. Hum. Reprod. 20, 3446-3451.
11. Simon, L., Lutton, D., McManus, J., Lewis, S.E.M., 2011. Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success. Fertil. Steril. 95, 652-657.
12. Venkatesh, S., Singh, A., Shamsi, M.B., Thilagavathi, J., Kumar, R., Mitra, D.K., Dada, R., 2011. Clinical significance of sperm DNA damage threshold value in the assessment of male infertility. Reprod. Sci. 18, 1005-1013.
13. Zini, A., 2011. Are sperm chromatin and DNA defects relevant in the clinic? Syst. Biol. Reprod. Med. 57, 78-85.