메뉴 건너뛰기




Volumn 4, Issue DEC, 2014, Pages

Cardiovascular toxicities from systemic breast cancer therapy

Author keywords

Anthracycline; Breast cancer; Cardiotoxicity; Chemotherapy; Heart failure; Trastuzumab

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTHRACYCLINE; BEVACIZUMAB; BRAIN NATRIURETIC PEPTIDE; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DEFERASIROX; DNA TOPOISOMERASE (ATP HYDROLYSING); DOCETAXEL; DOXORUBICIN; ENALAPRIL; EPIRUBICIN; LAPATINIB; PACLITAXEL; PERTUZUMAB; PLACEBO; TRASTUZUMAB; TROPONIN I; UBIDECARENONE;

EID: 84922512485     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00346     Document Type: Review
Times cited : (22)

References (95)
  • 1
    • 84896506628 scopus 로고    scopus 로고
    • Cancer Treatment and Survivorship Facts and Figures, 2014-2015.
    • Atlanta: American Cancer Society
    • American Cancer Society. Cancer Treatment and Survivorship Facts and Figures, 2014-2015. Atlanta: American Cancer Society (2014).
    • (2014)
  • 2
    • 0032547564 scopus 로고    scopus 로고
    • Early breast cancer trialists' collaborative group
    • Polychemotherapy for early breast cancer: an overview of the randomised trials. Early breast cancer trialists' collaborative group. Lancet (1998) 352(9132):930-42. doi:10.1016/S0140-6736(98)03301-7
    • (1998) Lancet , vol.352 , Issue.9132 , pp. 930-942
  • 3
    • 0027471578 scopus 로고
    • Chemotherapy and survival in advanced breast cancer: the inclusion of doxorubicin in Cooper type regimens
    • A'Hern RP, Smith IE, Ebbs SR. Chemotherapy and survival in advanced breast cancer: the inclusion of doxorubicin in Cooper type regimens. Br J Cancer (1993) 67(4):801-5. doi:10.1038/bjc.1993.146
    • (1993) Br J Cancer , vol.67 , Issue.4 , pp. 801-805
    • A'Hern, R.P.1    Smith, I.E.2    Ebbs, S.R.3
  • 5
    • 0015849162 scopus 로고
    • A clinicopathologic analysis of adriamycin cardiotoxicity
    • Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer (1973) 32(2):302-14. doi:10.1002/1097-0142(197308)32:2<302::AID-CNCR2820320205>3.0.CO;2-2
    • (1973) Cancer , vol.32 , Issue.2 , pp. 302-314
    • Lefrak, E.A.1    Pitha, J.2    Rosenheim, S.3    Gottlieb, J.A.4
  • 6
    • 0025850827 scopus 로고
    • Cardiac toxicity 4 to 20 years after completing anthracycline therapy
    • Steinherz LJ, Steinherz PG, Tan CT, Heller G, Murphy ML. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA (1991) 266(12):1672-7. doi:10.1001/jama.266.12.1672
    • (1991) JAMA , vol.266 , Issue.12 , pp. 1672-1677
    • Steinherz, L.J.1    Steinherz, P.G.2    Tan, C.T.3    Heller, G.4    Murphy, M.L.5
  • 7
    • 0035155497 scopus 로고    scopus 로고
    • Anthracycline-induced clinical heart failure in a cohort of 607 children: long-term follow-up study.
    • Kremer LC, van Dalen EC, Offringa M, Ottenkamp J, Voute PA. Anthracycline-induced clinical heart failure in a cohort of 607 children: long-term follow-up study. J Clin Oncol (2001) 19(1):191-6.
    • (2001) J Clin Oncol , vol.19 , Issue.1 , pp. 191-196
    • Kremer, L.C.1    van Dalen, E.C.2    Offringa, M.3    Ottenkamp, J.4    Voute, P.A.5
  • 9
    • 0028348959 scopus 로고
    • Assessment of anthracycline cardiomyopathy by endomyocardial biopsy
    • Mackay B, Ewer MS, Carrasco CH, Benjamin RS. Assessment of anthracycline cardiomyopathy by endomyocardial biopsy. Ultrastruct Pathol (1994) 18(1-2):203-11. doi:10.3109/01913129409016291
    • (1994) Ultrastruct Pathol , vol.18 , Issue.1-2 , pp. 203-211
    • Mackay, B.1    Ewer, M.S.2    Carrasco, C.H.3    Benjamin, R.S.4
  • 10
    • 0038521374 scopus 로고    scopus 로고
    • Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
    • Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer (2003) 97(11):2869-79. doi:10.1002/cncr.11407
    • (2003) Cancer , vol.97 , Issue.11 , pp. 2869-2879
    • Swain, S.M.1    Whaley, F.S.2    Ewer, M.S.3
  • 11
    • 84888644213 scopus 로고    scopus 로고
    • Review and meta-analysis of incidence and clinical predictors of anthracycline cardiotoxicity
    • Lotrionte M, Biondi-Zoccai G, Abbate A, Lanzetta G, D'Ascenzo F, Malavasi V, et al. Review and meta-analysis of incidence and clinical predictors of anthracycline cardiotoxicity. Am J Cardiol (2013) 112(12):1980-4. doi:10.1016/j.amjcard.2013.08.026
    • (2013) Am J Cardiol , vol.112 , Issue.12 , pp. 1980-1984
    • Lotrionte, M.1    Biondi-Zoccai, G.2    Abbate, A.3    Lanzetta, G.4    D'Ascenzo, F.5    Malavasi, V.6
  • 12
    • 33644840267 scopus 로고    scopus 로고
    • Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study
    • Doyle JJ, Neugut AI, Jacobson JS, Grann VR, Hershman DL. Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol (2005) 23(34):8597-605. doi:10.1200/JCO.2005.02.5841
    • (2005) J Clin Oncol , vol.23 , Issue.34 , pp. 8597-8605
    • Doyle, J.J.1    Neugut, A.I.2    Jacobson, J.S.3    Grann, V.R.4    Hershman, D.L.5
  • 14
    • 84863001655 scopus 로고    scopus 로고
    • Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children
    • Visscher H, Ross CJ, Rassekh SR, Barhdadi A, Dube MP, Al-Saloos H, et al. Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children. J Clin Oncol (2012) 30(13):1422-8. doi:10.1200/JCO.2010.34.3467
    • (2012) J Clin Oncol , vol.30 , Issue.13 , pp. 1422-1428
    • Visscher, H.1    Ross, C.J.2    Rassekh, S.R.3    Barhdadi, A.4    Dube, M.P.5    Al-Saloos, H.6    Et, al.7
  • 15
    • 81855225220 scopus 로고    scopus 로고
    • Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes - a report from the Children's Oncology Group
    • Blanco JG, Sun CL, Landier W, Chen L, Esparza-Duran D, Leisenring W, et al. Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes - a report from the Children's Oncology Group. J Clin Oncol (2012) 30(13):1415-21. doi:10.1200/JCO.2011.34.8987
    • (2012) J Clin Oncol , vol.30 , Issue.13 , pp. 1415-1421
    • Blanco, J.G.1    Sun, C.L.2    Landier, W.3    Chen, L.4    Esparza-Duran, D.5    Leisenring, W.6
  • 16
    • 0020583667 scopus 로고
    • A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine
    • Myers C, Bonow R, Palmeri S, Jenkins J, Corden B, Locker G, et al. A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine. Semin Oncol (1983) 10(1 Suppl 1):53-5.
    • (1983) Semin Oncol , vol.10 , Issue.1 , pp. 53-55
    • Myers, C.1    Bonow, R.2    Palmeri, S.3    Jenkins, J.4    Corden, B.5    Locker, G.6
  • 18
    • 66949171305 scopus 로고    scopus 로고
    • Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron
    • Simunek T, Sterba M, Popelova O, Adamcova M, Hrdina R, Gersl V. Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol Rep (2009) 61(1):154-71. doi:10.1016/S1734-1140(09)70018-0
    • (2009) Pharmacol Rep , vol.61 , Issue.1 , pp. 154-171
    • Simunek, T.1    Sterba, M.2    Popelova, O.3    Adamcova, M.4    Hrdina, R.5    Gersl, V.6
  • 19
    • 0345306160 scopus 로고    scopus 로고
    • The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin
    • Hasinoff BB, Patel D, Wu X. The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin. Free Radic Biol Med (2003) 35(11):1469-79. doi:10.1016/j.freeradbiomed.2003.08.005
    • (2003) Free Radic Biol Med , vol.35 , Issue.11 , pp. 1469-1479
    • Hasinoff, B.B.1    Patel, D.2    Wu, X.3
  • 20
    • 84869209094 scopus 로고    scopus 로고
    • Identification of the molecular basis of doxorubicin-induced cardiotoxicity
    • Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med (2012) 18(11):1639-42. doi:10.1038/nm.2919
    • (2012) Nat Med , vol.18 , Issue.11 , pp. 1639-1642
    • Zhang, S.1    Liu, X.2    Bawa-Khalfe, T.3    Lu, L.S.4    Lyu, Y.L.5    Liu, L.F.6
  • 22
    • 0030991044 scopus 로고    scopus 로고
    • Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy
    • Swain SM, Whaley FS, Gerber MC, Ewer MS, Bianchine JR, Gams RA. Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy. J Clin Oncol (1997) 15(4):1333-40.
    • (1997) J Clin Oncol , vol.15 , Issue.4 , pp. 1333-1340
    • Swain, S.M.1    Whaley, F.S.2    Gerber, M.C.3    Ewer, M.S.4    Bianchine, J.R.5    Gams, R.A.6
  • 23
    • 0030904096 scopus 로고    scopus 로고
    • Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer
    • Swain SM, Whaley FS, Gerber MC, Weisberg S, York M, Spicer D, et al. Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol (1997) 15(4):1318-32.
    • (1997) J Clin Oncol , vol.15 , Issue.4 , pp. 1318-1332
    • Swain, S.M.1    Whaley, F.S.2    Gerber, M.C.3    Weisberg, S.4    York, M.5    Spicer, D.6
  • 24
    • 33645294906 scopus 로고    scopus 로고
    • Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy
    • Marty M, Espie M, Llombart A, Monnier A, Rapoport BL, Stahalova V. Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy. Ann Oncol (2006) 17(4):614-22. doi:10.1093/annonc/mdj134
    • (2006) Ann Oncol , vol.17 , Issue.4 , pp. 614-622
    • Marty, M.1    Espie, M.2    Llombart, A.3    Monnier, A.4    Rapoport, B.L.5    Stahalova, V.6
  • 25
    • 10544231456 scopus 로고    scopus 로고
    • Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer
    • Venturini M, Michelotti A, Del Mastro L, Gallo L, Carnino F, Garrone O, et al. Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer. J Clin Oncol (1996) 14(12):3112-20.
    • (1996) J Clin Oncol , vol.14 , Issue.12 , pp. 3112-3120
    • Venturini, M.1    Michelotti, A.2    Del Mastro, L.3    Gallo, L.4    Carnino, F.5    Garrone, O.6
  • 26
    • 0033113566 scopus 로고    scopus 로고
    • Use of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer
    • Seymour L, Bramwell V, Moran LA. Use of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. The provincial systemic treatment disease site group. Cancer Prev Control (1999) 3(2):145-59.
    • (1999) The provincial systemic treatment disease site group. Cancer Prev Control , vol.3 , Issue.2 , pp. 145-159
    • Seymour, L.1    Bramwell, V.2    Moran, L.A.3
  • 27
    • 0024573486 scopus 로고
    • The interaction of the cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yL)propane); its hydrolysis product (ICRF-198); and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin
    • Hasinoff BB. The interaction of the cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yL)propane); its hydrolysis product (ICRF-198); and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin. Agents Actions (1989) 26(3-4):378-85. doi:10.1007/BF01967305
    • (1989) Agents Actions , vol.26 , Issue.3-4 , pp. 378-385
    • Hasinoff, B.B.1
  • 28
    • 0027517827 scopus 로고
    • The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925
    • Hasinoff BB, Kala SV. The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925. Agents Actions (1993) 39(1-2):72-81. doi:10.1007/BF01975717
    • (1993) Agents Actions , vol.39 , Issue.1-2 , pp. 72-81
    • Hasinoff, B.B.1    Kala, S.V.2
  • 29
    • 84891009434 scopus 로고    scopus 로고
    • Topoisomerase 2beta: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity
    • Vejpongsa P, Yeh ET. Topoisomerase 2beta: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther (2014) 95(1):45-52. doi:10.1038/clpt.2013.201
    • (2014) Clin Pharmacol Ther , vol.95 , Issue.1 , pp. 45-52
    • Vejpongsa, P.1    Yeh, E.T.2
  • 30
    • 57449120634 scopus 로고    scopus 로고
    • Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy
    • Martin E, Thougaard AV, Grauslund M, Jensen PB, Bjorkling F, Hasinoff BB, et al. Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy. Toxicology (2009) 255(1-2):72-9. doi:10.1016/j.tox.2008.10.011
    • (2009) Toxicology , vol.255 , Issue.1-2 , pp. 72-79
    • Martin, E.1    Thougaard, A.V.2    Grauslund, M.3    Jensen, P.B.4    Bjorkling, F.5    Hasinoff, B.B.6
  • 31
    • 0024546425 scopus 로고
    • Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma
    • Hortobagyi GN, Frye D, Buzdar AU, Ewer MS, Fraschini G, Hug V, et al. Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma. Cancer (1989) 63(1):37-45. doi:10.1002/1097-0142(19890101)63:1<37::AID-CNCR2820630106>3.0.CO;2-Z
    • (1989) Cancer , vol.63 , Issue.1 , pp. 37-45
    • Hortobagyi, G.N.1    Frye, D.2    Buzdar, A.U.3    Ewer, M.S.4    Fraschini, G.5    Hug, V.6
  • 32
    • 77953931502 scopus 로고    scopus 로고
    • Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials.
    • Smith LA, Cornelius VR, Plummer CJ, Levitt G, Verrill M, Canney P, et al. Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials. BMC Cancer (2010) 10:337. doi:10.1186/1471-2407-10-337
    • (2010) BMC Cancer , vol.10 , pp. 337
    • Smith, L.A.1    Cornelius, V.R.2    Plummer, C.J.3    Levitt, G.4    Verrill, M.5    Canney, P.6
  • 34
    • 0021833736 scopus 로고
    • A prospective randomized comparison of epirubicin and doxorubicin in patients with advanced breast cancer
    • Jain KK, Casper ES, Geller NL, Hakes TB, Kaufman RJ, Currie V, et al. A prospective randomized comparison of epirubicin and doxorubicin in patients with advanced breast cancer. J Clin Oncol (1985) 3(6):818-26.
    • (1985) J Clin Oncol , vol.3 , Issue.6 , pp. 818-826
    • Jain, K.K.1    Casper, E.S.2    Geller, N.L.3    Hakes, T.B.4    Kaufman, R.J.5    Currie, V.6
  • 35
    • 0038783150 scopus 로고    scopus 로고
    • Epirubicin versus doxorubicin: which is the anthracycline of choice for the treatment of breast cancer?
    • Kaklamani VG, Gradishar WJ. Epirubicin versus doxorubicin: which is the anthracycline of choice for the treatment of breast cancer? Clin Breast Cancer (2003) 4(Suppl 1):S26-33. doi:10.3816/CBC.2003.s.012
    • (2003) Clin Breast Cancer , vol.4 , pp. S26-33
    • Kaklamani, V.G.1    Gradishar, W.J.2
  • 36
  • 37
  • 38
    • 49449107089 scopus 로고    scopus 로고
    • New insight into epirubicin cardiac toxicity: competing risks analysis of 1097 breast cancer patients
    • Ryberg M, Nielsen D, Cortese G, Nielsen G, Skovsgaard T, Andersen PK. New insight into epirubicin cardiac toxicity: competing risks analysis of 1097 breast cancer patients. J Natl Cancer Inst (2008) 100(15):1058-67. doi:10.1093/jnci/djn206
    • (2008) J Natl Cancer Inst , vol.100 , Issue.15 , pp. 1058-1067
    • Ryberg, M.1    Nielsen, D.2    Cortese, G.3    Nielsen, G.4    Skovsgaard, T.5    Andersen, P.K.6
  • 39
    • 19944396126 scopus 로고    scopus 로고
    • The role of the liposomal anthracyclines and other systemic therapies in the management of advanced breast cancer
    • Robert NJ, Vogel CL, Henderson IC, Sparano JA, Moore MR, Silverman P, et al. The role of the liposomal anthracyclines and other systemic therapies in the management of advanced breast cancer. Semin Oncol (2004) 31(6 Suppl 13):106-46. doi:10.1053/j.seminoncol.2004.09.018
    • (2004) Semin Oncol , vol.31 , Issue.6 , pp. 106-146
    • Robert, N.J.1    Vogel, C.L.2    Henderson, I.C.3    Sparano, J.A.4    Moore, M.R.5    Silverman, P.6
  • 41
    • 11144357506 scopus 로고    scopus 로고
    • Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    • O'Brien ME, Wigler N, Inbar M, Rosso R, Grischke E, Santoro A, et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol (2004) 15(3):440-9. doi:10.1093/annonc/mdh097
    • (2004) Ann Oncol , vol.15 , Issue.3 , pp. 440-449
    • O'Brien, M.E.1    Wigler, N.2    Inbar, M.3    Rosso, R.4    Grischke, E.5    Santoro, A.6
  • 42
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (1987) 235(4785):177-82. doi:10.1126/science.3798106
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 43
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens MA, Horten BC, Da Silva MM. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer (2004) 5(1):63-9. doi:10.3816/CBC.2004.n.011
    • (2004) Clin Breast Cancer , vol.5 , Issue.1 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    Da Silva, M.M.3
  • 44
    • 0026059293 scopus 로고
    • Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer
    • Kallioniemi OP, Holli K, Visakorpi T, Koivula T, Helin HH, Isola JJ. Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer. Int J Cancer (1991) 49(5):650-5. doi:10.1002/ijc.2910490504
    • (1991) Int J Cancer , vol.49 , Issue.5 , pp. 650-655
    • Kallioniemi, O.P.1    Holli, K.2    Visakorpi, T.3    Koivula, T.4    Helin, H.H.5    Isola, J.J.6
  • 45
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med (2001) 344(11):783-92. doi:10.1056/NEJM200103153441101
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3    Fuchs, H.4    Paton, V.5    Bajamonde, A.6
  • 46
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med (2005) 353(16):1673-84. doi:10.1056/NEJMoa052122
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3    Suman, V.J.4    Geyer, C.E.5    Davidson, N.E.6
  • 49
    • 80052728749 scopus 로고    scopus 로고
    • Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31
    • Perez EA, Romond EH, Suman VJ, Jeong JH, Davidson NE, Geyer CE Jr., et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol (2011) 29(25):3366-73. doi:10.1200/JCO.2011.35.0868
    • (2011) J Clin Oncol , vol.29 , Issue.25 , pp. 3366-3373
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3    Jeong, J.H.4    Davidson, N.E.5    Geyer, C.E.6
  • 50
    • 33344478381 scopus 로고    scopus 로고
    • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    • Joensuu H, Kellokumpu-Lehtinen PL, Bono P, Alanko T, Kataja V, Asola R, et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med (2006) 354(8):809-20. doi:10.1056/NEJMoa053028
    • (2006) N Engl J Med , vol.354 , Issue.8 , pp. 809-820
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.L.2    Bono, P.3    Alanko, T.4    Kataja, V.5    Asola, R.6
  • 51
    • 29744442709 scopus 로고    scopus 로고
    • Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31
    • Tan-Chiu E, Yothers G, Romond E, Geyer CE Jr, Ewer M, Keefe D, et al. Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol (2005) 23(31):7811-9. doi:10.1200/jco.2005.02.4091
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 7811-7819
    • Tan-Chiu, E.1    Yothers, G.2    Romond, E.3    Geyer, C.E.4    Ewer, M.5    Keefe, D.6
  • 52
    • 41649083764 scopus 로고    scopus 로고
    • Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial
    • Perez EA, Suman VJ, Davidson NE, Sledge GW, Kaufman PA, Hudis CA, et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol (2008) 26(8):1231-8. doi:10.1200/JCO.2007.13.5467
    • (2008) J Clin Oncol , vol.26 , Issue.8 , pp. 1231-1238
    • Perez, E.A.1    Suman, V.J.2    Davidson, N.E.3    Sledge, G.W.4    Kaufman, P.A.5    Hudis, C.A.6
  • 53
    • 84884418164 scopus 로고    scopus 로고
    • 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial
    • Goldhirsch A, Gelber RD, Piccart-Gebhart MJ, de Azambuja E, Procter M, Suter TM, et al. 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet (2013) 382(9897):1021-8. doi:10.1016/S0140-6736(13)61094-6
    • (2013) Lancet , vol.382 , Issue.9897 , pp. 1021-1028
    • Goldhirsch, A.1    Gelber, R.D.2    Piccart-Gebhart, M.J.3    de Azambuja, E.4    Procter, M.5    Suter, T.M.6
  • 54
    • 34548444589 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials.
    • Viani GA, Afonso SL, Stefano EJ, De Fendi LI, Soares FV. Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer (2007) 7:153. doi:10.1186/1471-2407-7-153
    • (2007) BMC Cancer , vol.7 , pp. 153
    • Viani, G.A.1    Afonso, S.L.2    Stefano, E.J.3    De Fendi, L.I.4    Soares, F.V.5
  • 56
    • 84905858933 scopus 로고    scopus 로고
    • Trastuzumab-associated cardiac events at 8 years of median follow-up in the herceptin adjuvant trial (BIG 1-01)
    • de Azambuja E, Procter MJ, van Veldhuisen DJ, Agbor-Tarh D, Metzger-Filho O, Steinseifer J, et al. Trastuzumab-associated cardiac events at 8 years of median follow-up in the herceptin adjuvant trial (BIG 1-01). J Clin Oncol (2014) 32(20):2159-65. doi:10.1200/JCO.2013.53.9288
    • (2014) J Clin Oncol , vol.32 , Issue.20 , pp. 2159-2165
    • de Azambuja, E.1    Procter, M.J.2    van Veldhuisen, D.J.3    Agbor-Tarh, D.4    Metzger-Filho, O.5    Steinseifer, J.6
  • 57
    • 77955284952 scopus 로고    scopus 로고
    • Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: a combined review of cardiac data from the National surgical adjuvant breast and bowel project B-31 and the North Central Cancer Treatment Group N9831 clinical trials
    • Russell SD, Blackwell KL, Lawrence J, Pippen JE Jr, Roe MT, Wood F, et al. Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: a combined review of cardiac data from the National surgical adjuvant breast and bowel project B-31 and the North Central Cancer Treatment Group N9831 clinical trials. J Clin Oncol (2010) 28(21):3416-21. doi:10.1200/JCO.2009.23.6950
    • (2010) J Clin Oncol , vol.28 , Issue.21 , pp. 3416-3421
    • Russell, S.D.1    Blackwell, K.L.2    Lawrence, J.3    Pippen, J.E.4    Roe, M.T.5    Wood, F.6
  • 58
    • 84866060182 scopus 로고    scopus 로고
    • Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study
    • Bowles EJ, Wellman R, Feigelson HS, Onitilo AA, Freedman AN, Delate T, et al. Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study. J Natl Cancer Inst (2012) 104(17):1293-305. doi:10.1093/jnci/djs317
    • (2012) J Natl Cancer Inst , vol.104 , Issue.17 , pp. 1293-1305
    • Bowles, E.J.1    Wellman, R.2    Feigelson, H.S.3    Onitilo, A.A.4    Freedman, A.N.5    Delate, T.6
  • 59
    • 84869125207 scopus 로고    scopus 로고
    • Seven-year follow-up assessment of cardiac function in NSABP B-31, a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel (ACP) with ACP plus trastuzumab as adjuvant therapy for patients with node-positive, human epidermal growth factor receptor 2-positive breast cancer
    • Romond EH, Jeong JH, Rastogi P, Swain SM, Geyer CE Jr, Ewer MS, et al. Seven-year follow-up assessment of cardiac function in NSABP B-31, a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel (ACP) with ACP plus trastuzumab as adjuvant therapy for patients with node-positive, human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol (2012) 30(31):3792-9. doi:10.1200/JCO.2011.40.0010
    • (2012) J Clin Oncol , vol.30 , Issue.31 , pp. 3792-3799
    • Romond, E.H.1    Jeong, J.H.2    Rastogi, P.3    Swain, S.M.4    Geyer, C.E.5    Ewer, M.S.6
  • 60
    • 0036498781 scopus 로고    scopus 로고
    • Cardiac dysfunction in the trastuzumab clinical trials experience
    • Seidman A, Hudis C, Pierri MK, Shak S, Paton V, Ashby M, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol (2002) 20(5):1215-21. doi:10.1200/JCO.20.5.1215
    • (2002) J Clin Oncol , vol.20 , Issue.5 , pp. 1215-1221
    • Seidman, A.1    Hudis, C.2    Pierri, M.K.3    Shak, S.4    Paton, V.5    Ashby, M.6
  • 61
    • 75149145066 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort
    • Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet (2010) 375(9712):377-84. doi:10.1016/S0140-6736(09)61964-4
    • (2010) Lancet , vol.375 , Issue.9712 , pp. 377-384
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3    Manikhas, A.4    Lluch, A.5    Tjulandin, S.6
  • 62
    • 19444378256 scopus 로고    scopus 로고
    • Type II chemotherapy-related cardiac dysfunction: time to recognize a new entity
    • Ewer MS, Lippman SM. Type II chemotherapy-related cardiac dysfunction: time to recognize a new entity. J Clin Oncol (2005) 23(13):2900-2. doi:10.1200/JCO.2005.05.827
    • (2005) J Clin Oncol , vol.23 , Issue.13 , pp. 2900-2902
    • Ewer, M.S.1    Lippman, S.M.2
  • 63
    • 32144448027 scopus 로고    scopus 로고
    • Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment
    • Ewer MS, Vooletich MT, Durand JB, Woods ML, Davis JR, Valero V, et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol (2005) 23(31):7820-6. doi:10.1200/JCO.2005.13.300
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 7820-7826
    • Ewer, M.S.1    Vooletich, M.T.2    Durand, J.B.3    Woods, M.L.4    Davis, J.R.5    Valero, V.6
  • 64
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • Kuramochi Y, Guo X, Sawyer DB. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol (2006) 41(2):228-35. doi:10.1016/j.yjmcc.2006.04.007
    • (2006) J Mol Cell Cardiol , vol.41 , Issue.2 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 65
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 8(5):459-65. doi:10.1038/nm0502-459
    • (2002) Nat Med , vol.8 , Issue.5 , pp. 459-465
    • Crone, S.A.1    Zhao, Y.Y.2    Fan, L.3    Gu, Y.4    Minamisawa, S.5    Liu, Y.6
  • 66
    • 33847708258 scopus 로고    scopus 로고
    • Heat shock protein 90 and ErbB2 in the cardiac response to doxorubicin injury
    • Gabrielson K, Bedja D, Pin S, Tsao A, Gama L, Yuan B, et al. Heat shock protein 90 and ErbB2 in the cardiac response to doxorubicin injury. Cancer Res (2007) 67(4):1436-41. doi:10.1158/0008-5472.CAN-06-3721
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1436-1441
    • Gabrielson, K.1    Bedja, D.2    Pin, S.3    Tsao, A.4    Gama, L.5    Yuan, B.6
  • 67
    • 74049164266 scopus 로고    scopus 로고
    • The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy
    • De Keulenaer GW, Doggen K, Lemmens K. The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy. Circ Res (2010) 106(1):35-46. doi:10.1161/CIRCRESAHA.109.205906
    • (2010) Circ Res , vol.106 , Issue.1 , pp. 35-46
    • De Keulenaer, G.W.1    Doggen, K.2    Lemmens, K.3
  • 68
    • 2342444610 scopus 로고    scopus 로고
    • Essential roles of Her2/erbB2 in cardiac development and function.
    • Negro A, Brar BK, Lee KF. Essential roles of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res (2004) 59:1-12. doi:10.1210/rp.59.1.1
    • (2004) Recent Prog Horm Res , vol.59 , pp. 1-12
    • Negro, A.1    Brar, B.K.2    Lee, K.F.3
  • 69
    • 34548132413 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure
    • Lemmens K, Doggen K, De Keulenaer GW. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation (2007) 116(8):954-60. doi:10.1161/CIRCULATIONAHA.107.690487
    • (2007) Circulation , vol.116 , Issue.8 , pp. 954-960
    • Lemmens, K.1    Doggen, K.2    De Keulenaer, G.W.3
  • 70
    • 85043219815 scopus 로고    scopus 로고
    • Long-term risk of heart failure associated with adjuvant trastuzumab in breast cancer patients
    • Goldhar HA, Yan A, Ko D, Earle C, Tomlinson GA, Trudeau M, et al. Long-term risk of heart failure associated with adjuvant trastuzumab in breast cancer patients. J Clin Oncol (2014) 32(15s):abstr9504.
    • (2014) J Clin Oncol , vol.32 , Issue.15
    • Goldhar, H.A.1    Yan, A.2    Ko, D.3    Earle, C.4    Tomlinson, G.A.5    Trudeau, M.6
  • 71
    • 84922558436 scopus 로고    scopus 로고
    • San Francisco, CA: Genentech, Inc
    • Herceptin (R) [package insert]. San Francisco, CA: Genentech, Inc (2014).
    • (2014)
  • 72
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med (2006) 355(26):2733-43. doi:10.1056/NEJMoa064320
    • (2006) N Engl J Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3    Chan, S.4    Romieu, C.G.5    Pienkowski, T.6
  • 73
    • 44949253343 scopus 로고    scopus 로고
    • Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials
    • Perez EA, Koehler M, Byrne J, Preston AJ, Rappold E, Ewer MS. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc (2008) 83(6):679-86. doi:10.4065/83.6.679
    • (2008) Mayo Clin Proc , vol.83 , Issue.6 , pp. 679-686
    • Perez, E.A.1    Koehler, M.2    Byrne, J.3    Preston, A.J.4    Rappold, E.5    Ewer, M.S.6
  • 74
    • 84905920752 scopus 로고    scopus 로고
    • First results from the phase III ALTTO trial (BIG 2-06; NCCTG [Alliance] N063D) comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T ? L), or their combination (T+L) in the adjuvant treatment of HER2-positive early breast cancer (EBC)
    • Piccart-Gebhart MJ, Holmes AP, Baselga J, De Azambuja E, Dueck AC, Viale G, et al. First results from the phase III ALTTO trial (BIG 2-06; NCCTG [Alliance] N063D) comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T ? L), or their combination (T+L) in the adjuvant treatment of HER2-positive early breast cancer (EBC). J Clin Oncol (2014) 32(18s):abstrLBA4.
    • (2014) J Clin Oncol , vol.32 , Issue.18
    • Piccart-Gebhart, M.J.1    Holmes, A.P.2    Baselga, J.3    De Azambuja, E.4    Dueck, A.C.5    Viale, G.6
  • 75
    • 84876970810 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
    • Swain SM, Kim SB, Cortes J, Ro J, Semiglazov V, Campone M, et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol (2013) 14(6):461-71. doi:10.1016/S1470-2045(13)70130-X
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. 461-471
    • Swain, S.M.1    Kim, S.B.2    Cortes, J.3    Ro, J.4    Semiglazov, V.5    Campone, M.6
  • 76
    • 84875421601 scopus 로고    scopus 로고
    • Cardiac tolerability of pertuzumab plus trastuzumab plus docetaxel in patients with HER2-positive metastatic breast cancer in CLEOPATRA: a randomized, double-blind, placebo-controlled phase III study
    • Swain SM, Ewer MS, Cortes J, Amadori D, Miles D, Knott A, et al. Cardiac tolerability of pertuzumab plus trastuzumab plus docetaxel in patients with HER2-positive metastatic breast cancer in CLEOPATRA: a randomized, double-blind, placebo-controlled phase III study. Oncologist (2013) 18(3):257-64. doi:10.1634/theoncologist.2012-0448
    • (2013) Oncologist , vol.18 , Issue.3 , pp. 257-264
    • Swain, S.M.1    Ewer, M.S.2    Cortes, J.3    Amadori, D.4    Miles, D.5    Knott, A.6
  • 77
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med (2012) 367(19):1783-91. doi:10.1056/NEJMoa1209124
    • (2012) N Engl J Med , vol.367 , Issue.19 , pp. 1783-1791
    • Verma, S.1    Miles, D.2    Gianni, L.3    Krop, I.E.4    Welslau, M.5    Baselga, J.6
  • 78
    • 0037303885 scopus 로고    scopus 로고
    • E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer
    • Miller KD. E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer. Clin Breast Cancer (2003) 3(6):421-2. doi:10.3816/CBC.2003.n.007
    • (2003) Clin Breast Cancer , vol.3 , Issue.6 , pp. 421-422
    • Miller, K.D.1
  • 79
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, Cortes J, Pivot X, Tomczak P, et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol (2010) 28(20):3239-47. doi:10.1200/JCO.2008.21.6457
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3    Cortes, J.4    Pivot, X.5    Tomczak, P.6
  • 80
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J, Brufsky AM, Bondarenko I, Lipatov ON, et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol (2011) 29(10):1252-60. doi:10.1200/JCO.2010.28.0982
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3    Brufsky, A.M.4    Bondarenko, I.5    Lipatov, O.N.6
  • 81
    • 84855161152 scopus 로고    scopus 로고
    • Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis
    • Cortes J, Calvo V, Ramirez-Merino N, O'Shaughnessy J, Brufsky A, Robert N, et al. Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis. Ann Oncol (2012) 23(5):1130-7. doi:10.1093/annonc/mdr432
    • (2012) Ann Oncol , vol.23 , Issue.5 , pp. 1130-1137
    • Cortes, J.1    Calvo, V.2    Ramirez-Merino, N.3    O'Shaughnessy, J.4    Brufsky, A.5    Robert, N.6
  • 82
    • 84883050174 scopus 로고    scopus 로고
    • Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial
    • Cameron D, Brown J, Dent R, Jackisch C, Mackey J, Pivot X, et al. Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial. Lancet Oncol (2013) 14(10):933-42. doi:10.1016/S1470-2045(13)70335-8
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 933-942
    • Cameron, D.1    Brown, J.2    Dent, R.3    Jackisch, C.4    Mackey, J.5    Pivot, X.6
  • 83
    • 84899906863 scopus 로고    scopus 로고
    • Primary results from BETH, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab ± bevacizumab in patients with HER2-positive, node-positive, or high-risk node-negative breast cancer. 2013 San Antonio Breast Cancer Symposium.
    • Slamon D, Swain S, Buyse MMM, Geyer CE, Im YH, et al. Primary results from BETH, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab ± bevacizumab in patients with HER2-positive, node-positive, or high-risk node-negative breast cancer. 2013 San Antonio Breast Cancer Symposium. Abstract S1-03 Cancer Res (2013) 73:S1-3. doi:10.1158/0008-5472.SABCS13-S1-03
    • (2013) Abstract S1-03 Cancer Res , vol.73 , pp. S1-S3
    • Slamon, D.1    Swain, S.2    Buyse, M.M.M.3    Geyer, C.E.4    Im, Y.H.5
  • 84
    • 84920917423 scopus 로고    scopus 로고
    • Bevacizumab (Bv) in the adjuvant treatment of HER2-negative breast cancer: Final results from Eastern cooperative oncology group E5103
    • Miller K, O'Neill A, Dang C, Northfelt DW, Gradishar WJ, Goldstein L. Bevacizumab (Bv) in the adjuvant treatment of HER2-negative breast cancer: Final results from Eastern cooperative oncology group E5103. J Clin Oncol (2014) 32(15s):abstr500.
    • (2014) J Clin Oncol , vol.32 , Issue.15
    • Miller, K.1    O'Neill, A.2    Dang, C.3    Northfelt, D.W.4    Gradishar, W.J.5    Goldstein, L.6
  • 85
    • 0031943236 scopus 로고    scopus 로고
    • VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
    • Hood JD, Meininger CJ, Ziche M, Granger HJ. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol (1998) 274(3 Pt 2):H1054-8.
    • (1998) Am J Physiol , vol.274 , Issue.3 , pp. H1054-H1058
    • Hood, J.D.1    Meininger, C.J.2    Ziche, M.3    Granger, H.J.4
  • 86
    • 0033855860 scopus 로고    scopus 로고
    • Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy
    • Cardinale D, Sandri MT, Martinoni A, Tricca A, Civelli M, Lamantia G, et al. Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy. J Am Coll Cardiol (2000) 36(2):517-22. doi:10.1016/S0735-1097(00)00748-8
    • (2000) J Am Coll Cardiol , vol.36 , Issue.2 , pp. 517-522
    • Cardinale, D.1    Sandri, M.T.2    Martinoni, A.3    Tricca, A.4    Civelli, M.5    Lamantia, G.6
  • 87
    • 2942522528 scopus 로고    scopus 로고
    • Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy
    • Cardinale D, Sandri MT, Colombo A, Colombo N, Boeri M, Lamantia G, et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation (2004) 109(22):2749-54. doi:10.1161/01.CIR.0000130926.51766.CC
    • (2004) Circulation , vol.109 , Issue.22 , pp. 2749-2754
    • Cardinale, D.1    Sandri, M.T.2    Colombo, A.3    Colombo, N.4    Boeri, M.5    Lamantia, G.6
  • 88
    • 23044510968 scopus 로고    scopus 로고
    • N-terminal pro-B-type natriuretic peptide after high-dose chemotherapy: a marker predictive of cardiac dysfunction?
    • Sandri MT, Salvatici M, Cardinale D, Zorzino L, Passerini R, Lentati P, et al. N-terminal pro-B-type natriuretic peptide after high-dose chemotherapy: a marker predictive of cardiac dysfunction? Clin Chem (2005) 51(8):1405-10. doi:10.1373/clinchem.2005.050153
    • (2005) Clin Chem , vol.51 , Issue.8 , pp. 1405-1410
    • Sandri, M.T.1    Salvatici, M.2    Cardinale, D.3    Zorzino, L.4    Passerini, R.5    Lentati, P.6
  • 89
    • 73549087024 scopus 로고    scopus 로고
    • Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy
    • Cardinale D, Colombo A, Lamantia G, Colombo N, Civelli M, De Giacomi G, et al. Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol (2010) 55(3):213-20. doi:10.1016/j.jacc.2009.03.095
    • (2010) J Am Coll Cardiol , vol.55 , Issue.3 , pp. 213-220
    • Cardinale, D.1    Colombo, A.2    Lamantia, G.3    Colombo, N.4    Civelli, M.5    De Giacomi, G.6
  • 90
    • 33845206791 scopus 로고    scopus 로고
    • Protective effects of carvedilol against anthracycline-induced cardiomyopathy
    • Kalay N, Basar E, Ozdogru I, Er O, Cetinkaya Y, Dogan A, et al. Protective effects of carvedilol against anthracycline-induced cardiomyopathy. J Am Coll Cardiol (2006) 48(11):2258-62. doi:10.1016/j.jacc.2006.07.052
    • (2006) J Am Coll Cardiol , vol.48 , Issue.11 , pp. 2258-2262
    • Kalay, N.1    Basar, E.2    Ozdogru, I.3    Er, O.4    Cetinkaya, Y.5    Dogan, A.6
  • 91
    • 33845402341 scopus 로고    scopus 로고
    • Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition
    • Cardinale D, Colombo A, Sandri MT, Lamantia G, Colombo N, Civelli M, et al. Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. Circulation (2006) 114(23):2474-81. doi:10.1161/CIRCULATIONAHA.106.635144
    • (2006) Circulation , vol.114 , Issue.23 , pp. 2474-2481
    • Cardinale, D.1    Colombo, A.2    Sandri, M.T.3    Lamantia, G.4    Colombo, N.5    Civelli, M.6
  • 92
    • 85043224319 scopus 로고    scopus 로고
    • Prevention of cardiac dysfunction during adjuvant breast cancer therapy: the PRADA study
    • Gulati G, Heck S, Ree AH, Bratland A, Stein K, Schulz-Menger J, et al. Prevention of cardiac dysfunction during adjuvant breast cancer therapy: the PRADA study. Cancer Res (2014) 74(19s):CT321. doi:10.1158/1538-7445.am2014-ct321
    • (2014) Cancer Res , vol.74 , Issue.19
    • Gulati, G.1    Heck, S.2    Ree, A.H.3    Bratland, A.4    Stein, K.5    Schulz-Menger, J.6
  • 93
    • 84885845957 scopus 로고    scopus 로고
    • ACCF/AHA guideline for the management of heart failure. A report of the American college of cardiology foundation/American heart association task force on practice guidelines.
    • O'Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, et al. 2013 ACCF/AHA guideline for the management of heart failure. A report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation (2013) 128:e240-327. doi:10.1161/CIR.0b013e31829e8776
    • (2013) Circulation 2013 , vol.128 , pp. e240-e327
    • O'Gara, P.T.1    Kushner, F.G.2    Ascheim, D.D.3    Casey, D.E.4    Chung, M.K.5    de Lemos, J.A.6
  • 94
    • 84866599720 scopus 로고    scopus 로고
    • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines
    • vii155-vii166
    • Curigliano G, Cardinale D, Suter T, Plataniotis G, de Azambuja E, Sandri MT, et al. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines. Ann Oncol (2012) 23(Suppl 7):vii155-66. doi:10.1093/annonc/mds293
    • (2012) Ann Oncol , vol.23
    • Curigliano, G.1    Cardinale, D.2    Suter, T.3    Plataniotis, G.4    de Azambuja, E.5    Sandri, M.T.6
  • 95
    • 73349115249 scopus 로고    scopus 로고
    • Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial
    • Joensuu H, Bono P, Kataja V, Alanko T, Kokko R, Asola R, et al. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. J Clin Oncol (2009) 27(34):5685-92. doi:10.1200/JCO.2008.21.4577
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5685-5692
    • Joensuu, H.1    Bono, P.2    Kataja, V.3    Alanko, T.4    Kokko, R.5    Asola, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.