Bringing cancer care to the poor: Experiences from Rwanda

Nature Reviews Cancer

Volumn 14, Issue 12, 2014, Pages 815-821

  Shulman, Lawrence N ^a,b   Mpunga, Tharcisse ^c,d   Tapela, Neo ^e,f   Wagner, Claire M ^a   Fadelu, Temidayo ^e   Binagwaho, Agnes ^c,g,h  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b Government of Rwanda ^*  (United States)

^c Ministry of Health   (Rwanda)

^d UNIVERSITY OF RWANDA   (Rwanda)

^e PARTNERS IN HEALTH   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CANCER VACCINE; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ERLOTINIB; GEFITINIB; GENERIC DRUG; METHOTREXATE; VINBLASTINE; VINCRISTINE;

BASIC RESEARCH; CANCER CARE; CANCER CHEMOTHERAPY; CANCER IMMUNIZATION; CANCER PREVENTION; CANCER RESEARCH; CANCER SCREENING; CANCER THERAPY; CLINICAL TRIAL (TOPIC); EARLY DIAGNOSIS; HEALTH CARE DELIVERY; HUMAN; LOWEST INCOME GROUP; MALIGNANT NEOPLASTIC DISEASE; MEDICAL ONCOLOGIST; PATIENT CARE; PRIORITY JOURNAL; REVIEW; RWANDA; SOCIAL STATUS; HEALTH CARE PLANNING; NEOPLASMS; POVERTY; STATISTICS AND NUMERICAL DATA;

DELIVERY OF HEALTH CARE; EARLY DETECTION OF CANCER; HEALTH RESOURCES; HEALTH SERVICES ACCESSIBILITY; HUMANS; NEOPLASMS; POVERTY; RWANDA;

EID: 84922480321     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3848     Document Type: Review

References (51)

1. Cancer Facts and Statistics. American Cancer Society [online], http://www.cancer.org/research/ cancerfactsstatistics/index
2. Schiffer, C. A. BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N. Engl. J. Med. 257, 258-265 (2007
3. Millot, F. et al. Imatinib is effective in children with previously untreated chronic myelogenous leukemia in early chronic phase: results of the French national phase IV trial. J. Clin. Oncol. 29, 2827-2832 (2011
4. Hudson, M. M., Link, M. P. & Simone, J. V. Milestones in the curability of pediatric cancers. J. Clin. Oncol. 32, 2391-2398 (2014
5. Ferlay, J. et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. International Agency for Research on Cancer [online], http://globocan.iarc.fr (2013
6. Sloan, F. A. & Gelgank, H. (eds) Cancer Control Opportunities in Low- and Middle-income Countries. (National Academies Press, 2007
7. Kanavos, P. The rising burden of cancer in the developing world. Ann. Oncol. 17 (Suppl. 8), viii15-viii23 (2006
8. Farmer, P. et al. Expansion of cancer care and control in countries of low and middle income: a call to action. Lancet. 376, 1186-1193 (2010
9. Magrath, I. & Litvak, J. Cancer in developing countries: opportunity and challenge. J. Natl Cancer Inst. 85, 862-874 (1993
10. Ngoma, T. WHO cancer priorities in developing countries. Ann. Oncol. 17 (Suppl. 8), viii9-viii14 (2006
11. United Nations General Assembly. Political Declaration of the High-Level Meeting of the General assembly on the Prevention and Control of Non-communicable Diseases. (UN, 2011
12. Farmer, P. et al. Community-based approaches to HIV treatment in resource-poor settings. Lancet. 358, 404-409 (2001
13. Bhakta, N., Martiniuk, A. L., Gupta, S. & Howard, S. C. The cost effectiveness of treating paediatric cancer in low-income and middle-income countries: a case-study approach using acute lymphocytic leukaemia in Brazil and Burkitt lymphoma in Malawi. Arch. Dis. Childhood 98, 155-160 (2013
14. Ruiz-Delgado, G. J. et al. Is there a benefit to adding rituximab to CHOP in the overall survival of patients with B cell non-Hodgkin's lymphoma in a developing country?. Hematology 17, 193-197 (2012
15. Mori, A. T., Kaale, E. A., Ngalesoni, F., Norheim, O. F. & Robberstad, B. The role of evidence in the decision-making process of selecting essential medicines in developing countries: the case of Tanzania. PloS one 9, e84824 (2014
16. Bazargani, Y. T., de Boer, A., Schellens, J. H. M., Leufkens, H. G. M. & Mantel-Teeuwisse, A. K. Selection of oncology medicines in low-And middle-income countries. Ann. Oncol., 25, 270-276 (2014
17. AIDSInfo. Joint U.N. Programme on HIV/AIDS. AIDSInfo online database [online], http:// aidsinfoonline.org/ (accessed 19 August, 2014
18. Rich, M. L. et al. Excellent clinical outcomes and high retention in care among adults in a community-based HIV treatment program in rural Rwanda. J. Acquir. Immun. Defic. Syndr. 59, e35-e42 (2012
19. Barton, M. B., Frommer, M. & Shafiq, J. Role of radiotherapy in cancer control in low-income and middle-income countries. Lancet Oncol. 7, 584-595 (2006
20. Rodin, D., Jaffray, D., Atun, R., Knaul, F. M. & Gospodarowicz, M. The need to expand global access to radiotherapy. Lancet Oncol. 15, 378-380 (2014
21. Gyorki, D. E., Muyco, A., Kushner, A. L., Brennan, M. F. & Kingham, T. P. Cancer surgery in low-income countries: an unmet need. Arch. Surg. 147, 1135-1140 (2012
22. Hopkins, J., Burns, E. & Eden, T. International twinning partnerships: An effective method of improving diagnosis, treatment and care for children with cancer in low-middle income countries. J. Cancer Policy. 1, e8-e19 (2013
23. Kutluk, T. & Torode, J. in Pediatric Hematology- Oncology in Countries with Limited Resources (eds Stefan, D. C. & Rodriguez-Galindo, C.) 19-24 (Springer, 2014
24. Ribeiro, R. C. Improving survival of children with cancer worldwide: the St. Jude International Outreach Program approach. Stud. Health Technol. Inform. 172, 9-13 (2012
25. Kingham, T. P. et al. Treatment of cancer in sub- Saharan Africa. Lancet. 14, e158-e167 (2013
26. Stefan, D. C. et al. Developing cancer control plans in Africa: examples from five countries. Lancet Onco. 14, e189-e195 (2013
27. National Institute of Statistics of Rwanda & Ministry of Finance and Economic Planning. Fourth Rwanda Population and Housing Census. Rwanda Labour Market Information System [online], http://www.lmis.gov.rw/scripts/publication/reports/Fourth%20 Rwanda%20Population%20and%20Housing%20 Census-Housing.pdf (2012
28. Farmer, P. E. et al. Reduced premature mortality in Rwanda: Lessons from success. BMJ 346, f65 (2013
29. Binagwaho, A. et al. Achieving high coverage in Rwanda's national human papillomavirus vaccination programme. Bull. World Health Organiz. 90, 623-628 (2012
30. World Health Organization. Global health expenditure database. WHO [online], http://apps. who.int/ (2014
31. Binagwaho, A. et al. Rwanda 20 years on: Investing in Life. Lancet 384, 371-375 (2014
32. Binagwaho, A. et al. The Human Resources For Health Program in Rwanda-A new partnership. N. Engl. J. Med. 369, 2054-2059 (2013
33. Hoverman, J. R. et al. Pathways, outcomes, and the costs in colon cancer: Retrospective evaluations in two distinct databases. J. Oncol. Pract. 7, 52s-59s (2011
34. Ávila, C., Loncar, D., Amico, P. & De Lay, P. Determinants of government HIV/AIDS financing: a 10 year trend analysis from 125 low- and middle-income countries. BMC Publ. Health 13, 673 (2013
35. Vermund, S. H. et al. Transitioning HIV care and treatment programs in southern Africa to full local management. AIDS 26, 1303 (2012
36. World Health Organization. Model List of Essential Medicines; Adults (18th Edition). WHO [online], http:// apps.who.int/iris/bitstream/10665/93142/1/EML-18- eng.pdf?ua=1 (2013
37. World Health Organization. Model List of Essential Medicines; Children (4th Edition). WHO [online], http:// apps.who.int/iris/bitstream/10665/93143/1/EMLc-4- eng.pdf?ua=1 (2013
38. Cleary, J. et al. Formulary availability and regulatory barriers to accessibility of opioids for cancer pain in Africa: A report from the Global Opioid Policy Initiative (GOPI). Ann. Oncol. 24 (Suppl. 11), xi14-xi23 (2013
39. Lamas, D. & Rosenbaum, L. Painful inequities- palliative care in developing countries. New Engl. J. Med. 366, 199-201 (2012
40. Neuss, M. N. et al. Measuring the improving quality of outpatient care in medical oncology practices in the United States. J. Clin. Oncol. 31, 1471-1477 (2013
41. American College of Surgeons. Commission on Cancer, Cancer Quality Improvement Program (CQIP). American College of Surgeons [online], http://www. facs.org/cancer/cocsource/2014/march.html (2014
42. Mubiligi, J. M. et al. Caring for patients with surgically resectable cancers: experience from a specialised centre in rural Rwanda. Publ. Health Action 4, 128-132 (2014
43. Mpunga, T. et al. Diagnosis of cancer in rural Rwanda: Early outcomes of a phased approach to implement anatomical pathology services in resource-limited settings. Am. J. Clin. Path. 143, 541-545 (2014
44. Pace, L. E. et al. Detailed analysis of reasons for delay in breast cancer diagnosis experienced by women prior to presentation at two cancer centers in Rwanda (Poster). NCI Symposium on Global Cancer Research. (2014
45. Tapela, N. et al. Implementation and preliminary findings of a comprehensive cancer center of excellence in rural Rwanda. Poster presentation at the Africa Organization for Research and Training in Cancer (AORTIC) Conference, Durban, South Africa. (21-24 November, 2013
46. Shyirambere, C. et al. Preliminary treatment outcomes for Wilms' tumor at a cancer center of excellence in rural Rwanda. Poster presentation at International Society of Pediatric Oncology (SIOP) Conference, Toronto, Canada. (22-25 October, 2014
47. Carey, L. et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295, 2492-2502 (2006
48. Murphy, A. et al. Molecular characterization of Wilms' tumor from a resource-constrained region of sub- Saharan Africa. Int. J. Cancer 131, E983-E994 (2012
49. Rebbeck, T. et al. Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of African descent. Prostate Cancer 2013, 560857 (2013
50. Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004
51. Singh, O., Chan, J., Lin, K., Heng, C. & Chowbay, B. ALC22A1 ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with Chronic Myeloid Leukemia. PLoS ONE 7, e51771 (2012