Assessment of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis

BMC Veterinary Research

Volumn 10, Issue 1, 2014, Pages

  Vilar, Jose M ^a   Batista, Miguel ^a   Morales, Manuel ^a   Santana, Angelo ^a   Cuervo, Belén ^b,c,d   Rubio, Mónica ^b,c,d   Cugat, Ramón ^b,c,e   Sopena, Joaquín ^b,c,d   Carrillo, Jose M ^b,c,d  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b UNIVERSIDAD CEU CARDENAL HERRERA   (Spain)

^c Garcia Cugat Foundation   (Spain)

^d Garcia Cugat Foundation UCH Chair   (Spain)

^e HOSPITAL QUIRÓN   (Spain)

Author keywords

Adipose derived mesenchymal stem cells; Force platform; Hip; MSC; Osteoarthrosis

Indexed keywords

ADIPOSE TISSUE; ANIMAL; ANIMAL LAMENESS; CASE CONTROL STUDY; CYTOLOGY; DOG; DOG DISEASES; DOUBLE BLIND PROCEDURE; FEMALE; GAIT; INTRAARTICULAR DRUG ADMINISTRATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; OSTEOARTHRITIS; PHYSIOLOGY; VETERINARY; WEIGHT BEARING;

ADIPOSE TISSUE; ANIMALS; CASE-CONTROL STUDIES; DOG DISEASES; DOGS; DOUBLE-BLIND METHOD; FEMALE; GAIT; INJECTIONS, INTRA-ARTICULAR; LAMENESS, ANIMAL; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; OSTEOARTHRITIS; WEIGHT-BEARING;

EID: 84922480296     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-10-143     Document Type: Article

References (38)

1. Bockstahler B, Krautler C, Holler P, Kotschwar A, Vobornik A, Peham C: Pelvic limb kinematics and surface electromyography of the vastus lateralis, biceps femoris, and gluteus medius muscle in dogs with hip osteoarthritis. Vet Surg 2012, 41:54-62.
2. Silvestre AM, Ginja MM, Ferreira AJ, Colaço J: Comparison of estimates of hip dysplasia genetic parameters in Estrela Mountain dog using linear and threshold models. J Anim Sci 2007, 85:1880-1884.
3. Maldonado M, Nam J: The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. Biomed Res Int 2013. http://dx.doi.org/10.1155/2013/284873.
4. Oldershaw R: Cell sources for the regeneration of articular cartilage: the past, the horizon and the future. Int Exp Path 2012, 93:389-400.
5. Pigott JH, Ishihara A, Wellman ML, Russell DS, Bertone AL: Inflammatory effects of autologous, genetically modified autologous, allogeneic, and xenogeneic mesenchymal stem cells after intra-articular injection in horses. Vet Comp Orthop Traumatol. In press.
6. Vilar JM, Morales M, Santana A, Spinella G, Rubio M, Cuervo B, Cugat R, Carrillo JM: Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs. BMC Vet Res 2013, 9:131.
7. Takemitsu H, Zhao D, Yamamoto I, Harada Y, Michishita M, Arai T: Comparison of bone marrow and adipose tissue-derived canine mesenchymal stem cells. BMC Vet Res 2012, 8:150.
8. Guercio A, Di Marco P, Casella S, Cannella V, Russotto L, Purpari G, Di Bella S, Piccione G: Production of canine mesenchymal stem cells from adipose tissue and their application in dogs with chronic osteoarthritis of the humeroradial joints. Cell Biol Int 2012, 36:189-94.
9. Agung M, Ochi M, Yanada S, Adachi N, Izuta Y, Yamasaki T, Toda K: Mobilization of bone marrow-derived mesenchymal stem cells into theinjured tissues after intraarticular injection and their contribution to tissueregeneration. Knee Surg Sports Traumatol Arthrosc 2006, 14:1307-1314.
10. Harman R, Cowles B, Orava C: A retrospective review of 62 cases of suspensory ligament injury insport horses treated with adipose-derived stem and regenerative cell therapy. In Proceedings of the Veterinary Orthopedic Society. Veterinary Orthopedic Society: Keystone; 2006:212-214.
11. Dahlgren LA: Use of adipose derived stem cells in tendon and ligament injuries. In Proceedings of the American College of Veterinary Surgeons Symposium Equine and Small Animal. Washington: American College of Veterinary Surgeons; 2006:150-151.
12. Nixon A, Dahlgren L, Haupt J, Yeager AE, Ward DL: Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis. Am J Vet Res 2008, 69:928-937.
13. Black LL, Gaynor J, Gahring D, Adams C, Aron D, Harman S, Gingerich DA, Harman R: Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther 2007, 8:272-84.
14. Black LL, Gaynor J, Adams C, Dhupa S, Sams AE, Taylor R, Harman S, Gingerich DA, Harman R: Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther 2008, 9:192-200.
15. Ball SG, Shuttleworth A, Kielty CM: Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells 2012, 30:548-60.
16. Rodríguez FJ, Valdés T, Carrillo JM, Rubio M, Monleon M, García DM, García M, Cugat R, Moreno V: Platelet-rich plasma favors proliferation of canine adipose-derived mesenchymal stem cells in methacrylate-endcapped caprolactone porous scaffold niches. J Funct Biomater 2012, 3:556-568.
17. Bennett RL, DeCamp CE, Flo GL, Hauptman JG, Stajich M: Kinematic gait analysis in dogs with hip dysplasia. Am J Vet Res 1996, 7:966-971.
18. Poy NS, DeCamp CE, Bennett RL, Hauptman JG: Additional kinematic variables to describe differences in the trot between clinically normal dogs and dogs with hip dysplasia. Am J Vet Res 2000, 8:974-978.
19. Gordon WJ, Conzemius MG, Riedesel E, Besancon MF, Evans R, Wilke V, Ritter MJ: The relationship betweenlimb function and radiographic osteoarthrosis in dogs with stifle osteoarthrosis. Vet Surg 2003, 32:451-454.
20. Voss K, Imhof J, Kaestner S, Montavon PM: Force plate gaitanalysis at the walk and trot in dogs with low-grade hindlimb lameness. Vet Comp Orthop Traumatol 2007, 20:299-304.
21. Evans R, Gordon W, Conzemius M: Effect of velocity on ground reaction forces in dogs with lameness attributable to tearing of the cranial cruciate ligament. Am J Vet Res 2003, 64:1479-1481.
22. Vilar JM, Morales M, Santana A, Batista M, Miró F, Spinella G: Long-term valuation of oral mavacoxib in Osteoarthrosic dogs using force platform analysis. Pak Vet J 2013, 33:229-233.
23. Moreau M, Lussier B, Doucet M, Vincent G, Martel-Pelletier J, Pelletier JP: Efficacy of licofelone in dogs with clinical osteoarthritis. Vet Rec 2007, 160:584-588.
24. Bennett RL, DeCamp CE, Flo GL, Hauptman JG, Stajich M: Kinematic gait analysis in dogs with hip dysplasia. Am J Vet Res 1996, 57:966-71.
25. DeCamp CE, Riggs CM, Olivier NB, Hauptman JG, Hottinger HA, Soutas-Little RW: Kinematic evaluation of gait in dogs with cranial cruciate ligament rupture. Am J Vet Res 1996, 57:120-126.
26. Budsberg SC, Johnston SA, Schwarz PD, DeCamp CE, Claxton R: Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs. J Am Vet Med Assoc 1999, 214:206-210.
27. Bigham-Sadegh A, Mirshokraei P, Karimi I, Oryan A, Aparviz A, Shafiei-Sarvestani Z: Effects of adipose tissue stem cell concurrent with greater omentum on experimental long-bone healing in dog. Connect Tissue Res 2012, 53:334-342.
28. Haghighat A, Akhavan A, Hashemi-Beni B, Deihimi P, Yadegari A, Heidari F: Adipose derived stem cells for treatment of mandibular bone defects: an autologous study in dogs. Dent Res J (Isfahan) 2011, 8(Suppl1):51-57.
29. Kang BJ, Ryu HH, Park SS, Koyama Y, Kikuchi M, Woo HM, Kim WH, Kweon OK: Comparing the osteogenic potential of canine mesenchymal cells derived from adipose tissues, bone marrow, umbilical cord blood, and wharton's jelly for treating bone defects. J Vet Sci 2012, 13:299-310.
30. Oh HJ, Park EJ, Lee SY, Soh JW, Kong IS, Choi SW, Ra JC, Kang SK, Lee BC: Comparison of cell proliferation and epigenetic modification of gene expression patterns in canine foetal fibroblasts and adipose tissue-derived mesenchymal stem cells. Cell Prolif 2012, 45:438-444.
31. Murphy JM, Fink DJ, Hunziker EB, Barry FP: Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003, 48:3464-3474.
32. Vogel PL: Surgeon's use of adipose stem cell therapy [abstract]. Vet Comp Orthop Traumatol 2012, 3:10.
33. Koh YG, Jo SB, Kwon OR, Suh DS, Lee SW, Park SH, Choi YJ: Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy 2013, 29:748-755.
34. Pinheiro J, Bates D: Fitting linear mixed-effects models. In Mixed-effects models in S and S-PLUS. 1st edition. Edited by Chambers J. New York: Springer-Verlag; 2000:133-197.
35. Milliken GA, Johnson DE: Analysis of mixed models/case studies of a mixed model. In Analysis of Messy Data, Volume 1. 2nd edition. Florida: Chapman and Hall; 2009:385-417.
36. Certificate for hip and elbow dysplasia. http://www.fci.be/uploaded_files/77-2001.pdf.
37. Piermattei D, Flo G, DeCamp C: Orthopedic examination and diagnostic tools. In Brinker, Piermattei and Flo's Handbook of Small Orthopedics and Fracture Repair. 4th edition. Edited by Fathman L. Missoury: Saunders; 2006:3-24.
38. R Development Core Team: R: A language and environment for statistical computing. http://www.R-project.org/.