Effects of L-Malic Acid on Alpha-Glucosidase: Inhibition Kinetics and Computational Molecular Dynamics Simulations

Applied Biochemistry and Biotechnology

Volumn 175, Issue 4, 2015, Pages 2232-2245

  Gou, Lin ^a   Zhan, Yi ^b   Lee, Jinhyuk ^c,d   Li, Xuan ^e   Lü, Zhi Rong ^b   Zhou, Hai Meng ^b   Lu, Hang ^a   Wang, Xi Yao ^a   Park, Yong Doo ^b   Yang, Jun Mo ^f  

^a SICHUAN AGRICULTURAL UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d University of Science and Technology (UST)   (South Korea)

^e ZHEJIANG SCI TECH UNIVERSITY   (China)

^f Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Alpha glucosidase; Inhibition; Malic acid

Indexed keywords

CATALYSIS; COMPUTATIONAL CHEMISTRY; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE; KINETICS; REACTION KINETICS; RED SHIFT;

ALPHA GLUCOSIDASE; COMPUTATIONAL SIMULATION; DOSE-DEPENDENT MANNER; INTRINSIC FLUORESCENCE; MALIC ACIDS; MOLECULAR DYNAMICS SIMULATIONS; STRUCTURAL CONFORMATIONS; TYPE 2 DIABETES MELLITUS;

MOLECULAR DYNAMICS;

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ALPHA GLUCOSIDASE; MALIC ACID; 8-ANILINO-1-NAPHTHALENESULFONIC ACID; ANTIDIABETIC AGENT; FLUORESCENT DYE; GLYCOSIDASE INHIBITOR; MALIC ACID DERIVATIVE; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME STRUCTURE; INHIBITION KINETICS; MOLECULAR DYNAMICS; SPECTROFLUOROMETRY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; KINETICS; MOLECULAR DOCKING; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; THERMODYNAMICS;

ALPHA-GLUCOSIDASES; ANILINO NAPHTHALENESULFONATES; CATALYTIC DOMAIN; FLUORESCENT DYES; GLYCOSIDE HYDROLASE INHIBITORS; HYPOGLYCEMIC AGENTS; KINETICS; MALATES; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; THERMODYNAMICS;

EID: 84922456035     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-014-1429-6     Document Type: Article

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