Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

Angewandte Chemie - International Edition

Volumn 54, Issue 7, 2015, Pages 2179-2184

  Adams, Luke A ^a   Sharma, Pooja ^a   Mohanty, Biswaranjan ^a   Ilyichova, Olga V ^a   Mulcair, Mark D ^a   Williams, Martin L ^a   Gleeson, Ellen C ^a   Totsika, Makrina ^b,d   Doak, Bradley C ^a   Caria, Sofia ^a   Rimmer, Kieran ^a   Horne, James ^a   Shouldice, Stephen R ^b   Vazirani, Mansha ^a   Headey, Stephen J ^a   Plumb, Brent R ^a   Martin, Jennifer L ^b   Heras, Begoҫa ^b,c   Simpson, Jamie S ^a   Scanlon, Martin J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; PROTEINS; SULFUR COMPOUNDS;

ANTIBACTERIAL COMPOUNDS; ANTIVIRULENCE AGENTS; BACTERIAL MOTILITY; CELL-BASED ASSAYS; FRAGMENT-BASED SCREENINGS; GRAM-NEGATIVE BACTERIA; MEDICINAL CHEMISTRY; SELECTIVE INHIBITION;

ESCHERICHIA COLI;

ANTIINFECTIVE AGENT; DSBA PROTEIN, E COLI; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; PROTEIN DISULFIDE ISOMERASE;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING;

ANTI-BACTERIAL AGENTS; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN DISULFIDE-ISOMERASES;

EID: 84922450745     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201410341     Document Type: Article

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