Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events

Psychoneuroendocrinology

Volumn 49, Issue 1, 2014, Pages 141-149

  Slavich, George M ^a   Tartter, Molly A ^a   Brennan, Patricia A ^b   Hammen, Constance ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

A118G; Adolescence; Disease; Genetic; Health; Opioid; Pain; Polymorphism; Risk; Stress

Indexed keywords

OPIATE; MU OPIATE RECEPTOR;

ADOLESCENT; ALLELE; ARTICLE; BECK DEPRESSION INVENTORY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENE; GENE EXPRESSION; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; GENOTYPING TECHNIQUE; HEALTH STATUS; HOMOZYGOTE; HUMAN; INTERVIEW; LIFE EVENT; LIFE STRESS; LONGITUDINAL STUDY; MAJOR DEPRESSION; MALE; MENTAL HEALTH; OPIOID REJECTION SENSITIVITY HYPOTHESIS; OPRM1 GENE; QUESTIONNAIRE; SELF REPORT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL REJECTION; ADOLESCENT BEHAVIOR; ATTITUDE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PSYCHOLOGY; YOUNG ADULT;

ADOLESCENT; ADOLESCENT BEHAVIOR; ALLELES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; LIFE CHANGE EVENTS; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU; REJECTION (PSYCHOLOGY); YOUNG ADULT;

EID: 84922419469     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2014.07.009     Document Type: Article

References (58)

1. Adrian C., Hammen C. Stress exposure and stress generation in children of depressed mothers. J. Consult. Clin. Psychol. 1993, 61:354-359.
2. Auerbach R.P., Ho M.H., Kim J.C. Identifying cognitive and interpersonal predictors of adolescent depression. J. Abnorm. Child Psychol. 2014, 42:913-924.
3. Barr C.S., Schwandt M.L., Lindell S.G., Higley J.D., Maestripieri D., Goldman D., Suomi S.J., Heilig M. Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:5277-5281.
4. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 1984, 7:309-338.
5. Beck A.T., Steer R.A., Brown G.K. Manual for the BDI-II 1996, Psychological Corporation, San Antonio, TX.
6. Berrocoso E., Sánchez-Blázquez P., Garzón J., Mico J.A. Opiates as antidepressants. Curr. Pharm. Des. 2009, 15:1612-1622.
7. Bertoletti E., Zanoni A., Giorda R., Battaglia M. Influence of the OPRM1 gene polymorphism upon children's degree of withdrawal and brain activation in response to facial expressions. Dev. Cogn. Neurosci. 2012, 2:103-109.
8. Brown G.W., Harris T.O. Social Origins of Depression: A Study of Psychiatric Disorder in Women 1978, Free Press, New York.
9. Couzin-Frankel J. Inflammation bares a dark side. Science 2010, 330:1621.
10. Dewall C.N., Macdonald G., Webster G.D., Masten C.L., Baumeister R.F., Powell C., Combs D., Schurtz D.R., Stillman T.F., Tice D.M., Eisenberger N.I. Acetaminophen reduces social pain: behavioral and neural evidence. Psychol. Sci. 2010, 21:931-937.
11. Drolet G., Dumont E.C., Gosselin I., Kinkead R., Laforest S., Trottier J.F. Role of endogenous opioid system in the regulation of the stress response. Prog. Neuropsychopharmacol. 2001, 4:729-741.
12. Eisenberger N.I., Lieberman M.D., Williams K.D. Does rejection hurt? An fMRI study of social exclusion. Science 2003, 302:290-292.
13. Farmer A.E., McGuffin P. Humiliation, loss and other types of life events and difficulties: a comparison of depressed subjects, healthy controls and their siblings. Psychol. Med. 2003, 33:1169-1175.
14. First M.B., Spitzer M.B., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version Non-patient Edition (SCID-I/NP) 2002, Biometrics Research Department, New York State Psychiatric Institute, New York.
15. Hammen C. Stress and depression. Annu. Rev. Clin. Psychol. 2005, 1:293-319.
16. Hammen C., Brennan P.A. Depressed adolescents of depressed and nondepressed mothers: tests of an interpersonal impairment hypothesis. J. Consult. Clin. Psychol. 2001, 69:284-294.
17. Hsu D.T., Sanford B.J., Meyers K.K., Love T.M., Hazlett K.E., Wang H., Ni L., Walker S.J., Mickey B.J., Korycinski S.T., Koeppe R.A., Crocker J.K., Langenecker S.A., Zubieta J.K. Response of the μ-opioid system to social rejection and acceptance. J. Mol. Psychiatry 2013, 18:1211-1217.
18. Huang P., Chen C., Mague S.D., Blendy J.A., Liu-Chen L.Y. A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. Biochem. J. 2012, 441:379-386.
19. Kalin N.H., Shelton S.E., Barksdale C.M. Opiate modulation of separation-induced distress in non-human primates. Brain Res. 1988, 440:285-292.
20. Kendler K.S., Hettema J.M., Butera F., Gardner C.O., Prescott C.A. Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch. Gen. Psychiatry 2003, 60:789-796.
21. Kross E., Berman M.G., Mischel W., Smith E.E., Wager T.D. Social rejection shares somatosensory representations with physical pain. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:6270-6275.
22. Liberzon I., Zubieta J.K., Fig L.M., Phan K.L., Koeppe R.A., Taylor S.F. Mu-opioid receptors and limbic responses to aversive emotional stimuli. Proc. Natl. Acad. Sci. U.S.A. 2002, 10:7084-7089.
23. MacDonald G., Leary M.R. Why does social exclusion hurt? The relationship between social and physical pain. Psychol. Bull. 2005, 131:202-223.
24. Mague S.D., Isiegas C., Huang P., Liu-Chen L.Y., Lerman C., Blendy J.A. Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10847-10852.
25. Masten C.L., Eisenberger N.I., Borofsky L.A., McNealy K., Pfeifer J.H., Dapretto M. Subgenual anterior cingulate responses to peer rejection: a marker of adolescents' risk for depression. Dev. Psychopathol. 2011, 23:283-292.
26. Millan M.J. Descending control of pain. Prog. Neurobiol. 2002, 66:355-474.
27. Miller G., Chen E., Cole S.W. Health psychology: developing biologically plausible models linking the social world and physical health. Annu. Rev. Psychol. 2009, 60:501-524.
28. Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65:732-741.
29. Monroe S.M., Slavich G.M., Georgiades K. The social environment and life stress in depression. Handbook of Depression, Second Edition 2009, 340-360. Guilford Press, New York. I.H. Gotlib, C.L. Hammen (Eds.).
30. Monroe S.M., Slavich G.M., Torres L.D., Gotlib I.H. Major life events and major chronic difficulties are differentially associated with history of major depressive episodes. J. Abnorm. Psychol. 2007, 116:116-124.
31. Murphy M.L.M., Slavich G.M., Chen E., Miller G.E. Targeted rejection predicts decreased anti-inflammatory gene expression and increased symptom severity in youth with asthma. Psychol. Sci. 2014, Under invited resubmission.
32. Murphy M.L.M., Slavich G.M., Rohleder N., Miller G.E. Targeted rejection triggers differential pro- and anti-inflammatory gene expression in adolescents as a function of social status. Clin. Psychol. Sci. 2013, 1:30-40.
33. Muscatell K.A., Slavich G.M., Monroe S.M., Gotlib I.H. Stressful life events, chronic difficulties, and the symptoms of clinical depression. J. Nerv. Ment. Dis. 2009, 197:154-160.
34. Oertel B.G., Kettner M., Scholich K., Renné C., Roskam B., Geisslinger G., Schmidt P.H., Lötsch J. A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. J. Biol. Chem. 2009, 284:6530-6535.
35. Panksepp J. Affective Neuroscience: The Foundations of Human and Animal Emotions 1998, Oxford University Press, New York.
36. Panksepp J. Feeling the pain of social loss. Science 2003, 302:237-239.
37. Panksepp J., Herman B., Conner R., Bishop P., Scott J.P. The biology of social attachments: opiates alleviate separation distress. Biol. Psychiatry 1978, 13:607-618.
38. Poole H., White S., Blake C., Murphy P., Bramwell R. Depression in chronic pain patients: prevalence and measurement. Pain Pract. 2009, 9:173-180.
39. Ray R., Ruparel K., Newberg A., Wileyto E.P., Loughead J.W., Divgi C., Blendy J.A., Logan J., Zubieta J.K., Lerman C. Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:9268-9273.
40. Saitoh A., Yamada M. Antidepressant-like effects of δ opioid receptor agonists in animal models. Curr. Neuropharmacol. 2012, 10:231-238.
41. Sia A.T., Lim Y., Lim E.C., Ocampo C.E., Lim W.Y., Cheong P., Tan E.C. Influence of mu-opioid receptor variant on morphine use and self-rated pain following abdominal hysterectomy. J. Pain 2013, 14:1045-1052.
42. Slavich G.M., Cole S.W. The emerging field of human social genomics. Clin. Psychol. Sci. 2013, 1:331-348.
43. Slavich G.M., Irwin M.R. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol. Bull. 2014, 140:774-815.
44. Slavich G.M., O'Donovan A., Epel E.S., Kemeny M.E. Black sheep get the blues: a psychobiological model of social rejection and depression. Neurosci. Biobehav. Rev. 2010, 35:39-45.
45. Slavich G.M., Thornton T., Torres L.D., Monroe S.M., Gotlib I.H. Targeted rejection predicts hastened onset of major depression. J. Soc. Clin. Psychol. 2009, 28:223-243.
46. Slavich G.M., Way B.M., Eisenberger N.I., Taylor S.E. Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:14817-14822.
47. Stroud C.B., Davila J., Hammen C., Vrshek-Schallhorn S. Severe and nonsevere events in first onsets versus recurrences of depression: evidence for stress sensitization. J. Abnorm. Psychol. 2011, 120:142-154.
48. Tan E.C., Lim E.C., Teo Y.Y., Lim Y., Law H.Y., Sia A.T. Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol. Pain 2009, 5:32-38.
49. Troisi A., Frazzetto G., Carola V., Di Lorenzo G., Coviello M., D'Amato F.R., Moles A., Siracusano A., Gross C. Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients. Soc. Neurosci. 2011, 6:88-97.
50. Troisi A., Frazzetto G., Carola V., Di Lorenzo G., Coviello M., Siracusano A., Gross C. Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment. Soc. Cogn. Affect. Neurosci. 2012, 7:542-547.
51. Van Houdenhove B., Luyten P., Tiber Egle U. Stress as a key concept in chronic widespread pain and fatigue disorders. J. Musculoskelet. Pain 2009, 17:390-399.
52. Wang Y.J., Huang P., Ung A., Blendy J.A., Liu-Chen L.Y. Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience 2012, 205:178-184.
53. Way B.M. Social relationships and public health: a social neuroscience perspective focusing on the opioid system. Social Neuroscience and Public Health: Foundations for the Science of Chronic Disease Prevention 2013, Springer, New York. P.A. Hall (Ed.).
54. Way B.M., Taylor S.E., Eisenberger N.I. Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:15079-15084.
55. Zhang Y., Wang D., Johnson A.D., Papp A.C., Sadée W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J. Biol. Chem. 2005, 280:32618-32624.
56. Zubieta J.K., Ketter T.A., Bueller J.A., Xu Y., Kilbourn M.R., Young E.A., Koeppe R.A. Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission. Arch. Gen. Psychiatry 2003, 60:1145-1153.
57. Zubieta J.K., Smith Y.R., Bueller J.A., Xu Y., Kilbourn M.R., Jewett D.M., Meyer C.R., Koeppe R.A., Stohler C.S. Regional mu-opioid receptor regulation of sensory and affective dimensions of pain. Science 2001, 293:311-315.
58. Zubieta J.K., Smith Y.R., Bueller J.A., Xu Y., Kilbourn M.R., Jewett D.M., Meyer C.R., Koeppe R.A., Stohler C.S. Mu-opioid receptor-mediated antinociceptive responses differ in men and women. J. Neurosci. 2002, 12:5100-5107.