Spinal sample showing p-JNK and P38 associated with the pain signaling transduction of glial cell in neuropathic pain

Spinal Cord

Volumn 53, Issue 2, 2015, Pages 92-97

  Cao, J ^a   Wang, J S ^b   Ren, X H ^a   Zang, W D ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Luohe Medical College   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; VIMENTIN; CELL NUCLEUS ANTIGEN; NERVE PROTEIN; NEUN PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BEHAVIOR CHANGE; CHRONIC CONSTRICTION INJURY; COMPARATIVE STUDY; CONTROLLED STUDY; GLIA CELL; IMMUNOHISTOCHEMISTRY; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL GANGLION; ANIMAL; CHRONIC DISEASE; DISEASE MODEL; ENZYMOLOGY; INJURIES; LUMBAR VERTEBRA; METABOLISM; NEURALGIA; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIGENS, NUCLEAR; ASTROCYTES; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GLIAL FIBRILLARY ACIDIC PROTEIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUMBAR VERTEBRAE; MALE; MAP KINASE SIGNALING SYSTEM; NERVE TISSUE PROTEINS; NEURALGIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN THRESHOLD; PHOSPHORYLATION; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD; VIMENTIN;

EID: 84922414926     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2014.188     Document Type: Article

References (17)

1. Uga H, Tsuda S. A one-step reverse transcription-polymerase chain reaction system for the simultaneous detection and identification of multiple tospovirus infections. Phytopathology 2005; 95: 166-171.
2. Raghavendra V, Tanga FY, DeLeo JA. Attenuation of morphine tolerance, withdrawalinduced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. Neuropsychopharmacology 2004; 29: 327-334.
3. Ji RR, Strichartz G. Cell signaling and the genesis of neuropathic pain. Sci STKE 2004; 2004: reE14.
4. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 2005; 438: 1017-1021.
5. Lee HJ, Shin YK, Park HT. Mitogen activated protein kinase family proteins and c-jun signaling in injury-induced Schwann cell plasticity. Exp Neurobiol 2014; 23: 130-137.
6. Yang DP, Kim J, Syed N, Tung YJ, Bhaskaran A, Mindos T et al. p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination. J Neurosci 2012; 32: 7158-7168.
7. Hossain S, de la Cruz-Morcillo MA, Sanchez-Prieto R, Almazan G. Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination. Glia 2012; 60: 1130-1144.
8. Zhuang ZY, Kawasaki Y, Tan PH, Wen YR, Huang J, Ji RR et al. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun 2007; 21: 642-651.
9. Zhu C, Yu ZB, Zhu JG, Hu XS, Chen YL, Qiu YF et al. Differential expression profile of micrornas during differentiation of cardiomyocytes exposed to polychlorinated biphenyls. Int J Mol Sci 2012; 13: 15955-15966.
10. Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y et al. PRSS3 promotes tumour growth and metastasis of human pancreatic cancer. Gut 2010; 59: 1535-1544.
11. Liu MG, Zhang FK, Guo SW, Zhao LF, An YY, Cui XY et al. Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex. Neurosci Lett 2007; 427: 39-43.
12. Basbaum AI, Braz JM. Transgenic mouse models for the tracing of 'pain' pathways. In: Kruger L, Light AR (eds). Translational Pain Research: From Mouse to Man. Frontiers in Neuroscience: Boca Raton, FL. 2010.
13. Wang YX, Xu XY, Su WL, Wang Q, Zhu WX, Chen F et al. Activation and clinical significance of p38 MAPK signaling pathway in patients with severe trauma. J Surg Res 2010; 161: 119-125.
14. Ji RR, Kawasaki Y, Zhuang ZY, Wen YR, Decosterd I. Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway. Neuron Glia Biol 2006; 2: 259-269.
15. Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR et al. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 2006; 26: 3551-3560.
16. Naik AK, Tandan SK, Dudhgaonkar SP, Jadhav SH, Kataria M, Prakash VR et al. Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J Pain 2006; 10: 573-579.
17. Warwick RA, Hanani M. The contribution of satellite glial cells to chemotherapyinduced neuropathic pain. Eur J Pain 2013; 17: 571-580.