Allopurinol initiation and change in blood pressure in older adults with hypertension

Hypertension

Volumn 64, Issue 5, 2014, Pages 1102-1107

  Beattie, Catherine J ^a   Fulton, Rachael L ^a   Higgins, Peter ^a   Padmanabhan, Sandosh ^a   McCallum, Linsay ^a   Walters, Matthew R ^a   Dominiczak, Anna F ^a   Touyz, Rhian M ^a   Dawson, Jesse ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Allopurinol; Hypertension; Therapeutics; Uric acid; Xanthine oxidase

Indexed keywords

ALLOPURINOL; URIC ACID; ENZYME INHIBITOR; XANTHINE OXIDASE;

AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE; CLINICAL PRACTICE; CLINICAL RESEARCH; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; DRUG MEGADOSE; DRUG USE; FEMALE; FOLLOW UP; GENERAL PRACTICE; HUMAN; HYPERTENSION; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TREND STUDY; URIC ACID BLOOD LEVEL; AGE; ANTAGONISTS AND INHIBITORS; BLOOD; CASE CONTROL STUDY; DOSE RESPONSE; DRUG EFFECTS; FACTUAL DATABASE; PATHOPHYSIOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS; TREATMENT OUTCOME; UNITED KINGDOM;

AGE FACTORS; AGED; ALLOPURINOL; BLOOD PRESSURE; CASE-CONTROL STUDIES; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GREAT BRITAIN; HUMANS; HYPERTENSION; MALE; REGRESSION ANALYSIS; TREATMENT OUTCOME; URIC ACID; XANTHINE OXIDASE;

EID: 84922393187     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.03953     Document Type: Article

References (24)

1. Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2011;63:102-110.
2. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38:1101-1106.
3. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ. Hyperuricaemia induces a primary renal arteriopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol. 2001;282:911-997.
4. Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300:924-932.
5. Soletsky B, Feig DI. Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension. 2012;60:1148-1156.
6. Dawson J, Jeemon P, Hetherington L, Judd C, Hastie C, Schulz C, Sloan W, Muir S, Jardine A, McInnes G, Morrison D, Dominiczak AF, Padmanabhan S, Walters M. Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension. 2013;62:105-111.
7. Agarwal V, Hans N, Messerli FH. Effect of allopurinol on blood pressure: a systematic review and meta-analysis. J Clin Hypertens (Greenwich). 2013;15:435-442.
8. Wood L, Martinez C. The general practice research database: role in pharmacovigilance. Drug Saf. 2004;27:871-881.
9. Walley T, Mantgani A. The UK General Practice Research Database. Lancet. 1997;350:1097-1099.
10. Lawson DH, Sherman V, Hollowell J. The General Practice Research Database. Scientific and Ethical Advisory Group. QJM. 1998;91:445-452.
11. Jick H, Jick SS, Derby LE. Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ. 1991;302:766-768.
12. Higgins P, Walters MR, Murray HM, McArthur K, McConnachie A, Lees KR, Dawson J. Allopurinol reduces brachial and central blood pressure, and carotid intima-media thickness progression after ischaemic stroke and transient ischaemic attack: a randomised controlled trial. Heart. 2014;100:1085-1092.
13. Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008;27:608-619.
14. Dawson J, Walters M. Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? Br J Clin Pharmacol. 2006;62:633-644.
15. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003;41:1183-1190.
16. Farquharson CA, Butler R, Hill A, Belch JJ, Struthers AD. Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation. 2002;106:221-226.
17. Butler R, Morris AD, Belch JJ, Hill A, Struthers AD. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension. 2000;35:746-751.
18. Rekhraj S, Gandy S, Szweijkowski B, Nadir MA, Noman A, Houston JG, Lang CC, George J, Struthers AD.High-Dose Allopurinol Reduces Left Ventricular Mass in Patients with Ischemic Heart Disease. Circulation. 2013;106:221-226.
19. Cappola TP, Kass DA, Nelson GS, Berger RD, Rosas GO, Kobeissi ZA, Marbán E, Hare JM. Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation. 2001;104:2407-2411.
20. Hirsch GA, Bottomley PA, Gerstenblith G, Weiss RG. Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol. 2012;59:802-808.
21. National Institute for Health and Care Excellence: British National Formulary. Allopurinol. http://www.evidence.nhs.uk/formulary/bnf/current/10-musculoskeletal-and-joint-diseases/101-drugs-used-in-rheumatic-diseases-and-gout/1014-gout-and-cytotoxic-induced-hyperuricaemia/long-term-control-of-gout/allopurinol. Accessed April 10, 2014.
22. Brand FN, McGee DL, Kannel WB, Stokes J III, Castelli WP. Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study. Am J Epidemiol. 1985;121:11-18.
23. Grodzicki T, Palmer A, Bulpitt CJ. Incidence of diabetes and gout in hypertensive patients during 8 years of follow-up. The General Practice Hypertension Study Group. J Hum Hypertens. 1997;11:583-585.
24. Morrison A, Ramey DR, van Adelsberg J, Watson DJ. Systematic review of trials of the effect of continued use of oral non-selective NSAIDs on blood pressure and hypertension. Curr Med Res Opin. 2007;23:2395-2404.