Measurement of the retinal arteriolar response to a hyperoxic provocation in nonsmokers and smokers, using a high-resolution confocal scanning laser ophthalmoscope

Journal of Biomedical Optics

Volumn 19, Issue 7, 2014, Pages

  O'Halloran, Margaret ^a   O'Donoghue, Eamonn ^b   Dainty, Chris ^c  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY HOSPITAL GALWAY   (Ireland)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

endothelium; high resolution imaging.; hyperoxia; retina; retinal vessel diameter; scanning laser ophthalmoscope; smoking; vascular reactivity

Indexed keywords

COMPUTER VISION; IMAGE RECONSTRUCTION; IMAGING TECHNIQUES; OXYGEN;

ENDOTHELIUM; HIGH-RESOLUTION IMAGING; HYPEROXIA; RETINA; RETINAL VESSELS; SCANNING LASER OPHTHALMOSCOPE; SMOKING;

OPHTHALMOLOGY;

ADULT; ANATOMY AND HISTOLOGY; CONFOCAL MICROSCOPY; DEVICES; FEMALE; HUMAN; HYPEROXIA; IMAGE PROCESSING; MALE; OPHTHALMOSCOPE; OPHTHALMOSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RETINA BLOOD VESSEL; SMOKING; YOUNG ADULT;

ADULT; FEMALE; HUMANS; HYPEROXIA; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MICROSCOPY, CONFOCAL; OPHTHALMOSCOPES; OPHTHALMOSCOPY; RETINAL VESSELS; SMOKING; YOUNG ADULT;

EID: 84922390734     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.19.7.076012     Document Type: Article

References (63)

1. J. R. Levick, An Introduction to Cardiovascular Physiology, 5th ed., Hodder Arnold, London, UK (2011).
2. I. O. Haefliger et al., "Endothelium-dependent vasoactive modulation in the ophthalmic circulation," Prog. Retin. Eye Res. 20(2), 209-225 (2001). (Pubitemid 32149927)
3. S. T. Venkataraman et al., "Retinal arteriolar and capillary vascular reactivity in response to isoxic hypercapnia," Exp. Eye Res. 87, 535-542 (2008).
4. M. J. Dumskyj et al., "Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis," Microvasc. Res. 51, 378-392 (1996).
5. P. Jeppesen, J. Sanye-Hajari, and T. Bek, "Increased blood pressure induces a diameter response of retinal arterioles that increases with decreasing arteriolar diameter," IOVS 48(1), 328-331 (2007). (Pubitemid 47251420)
6. F. Robinson et al., "Retinal blood flow autoregulation in response to an acute increase in blood pressure," IOVS 27(5), 722-726 (1986). (Pubitemid 16080489)
7. H. Tachibana, F. Gotoh, and Y. Ishikawa, "Retinal vascular autoregulation in normal subjects," Stroke 13(2), 149-155 (1982). (Pubitemid 12183634)
8. C. E. Riva, J. E. Grunwald, and B. L. Petrig, "Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry," IOVS 27(12), 1706-1712 (1986). (Pubitemid 17207842)
9. G. Garhöfer et al., "Effect of regular smoking on flicker induced retinal vasodilatation in healthy subjects," Microvasc. Res. 82(3), 351-355 (2011).
10. R. Heitmar and R. J. Summers, "Assessing vascular function using dynamic retinal diameter measurements: a new insight on the endothelium," Thromb. Haemost. 107, 1019-1026 (2012).
11. E. Nagel, W. Vilser, and I. Lanzl, "Age, blood pressure, and vessel diameter as factors influencing the arterial retinal flicker response," IOVS 45(5), 1486-1492 (2004). (Pubitemid 38859329)
12. K. Polak, L. Schmetterer, and C. E. Riva, "Influence of flicker frequency on flicker-induced changes of retinal vessel diameter," IOVS 43(8), 2721-2726 (2002). (Pubitemid 34809465)
13. C. J. Pournaras et al., "Regulation of retinal blood flow in health and disease," Prog. Retin. Eye Res. 27, 284-330 (2008).
14. S. Jean-Louis, J. V. Lovasik, and H. Kergoat, "Systemic hyperoxia and retinal vasomotor responses," IOVS 46(5), 1714-1720 (2005). (Pubitemid 44843608)
15. B. Kiss et al., "Retinal blood flow during hyperoxia in humans revisited: concerted results using different measurement techniques," Microvasc. Res. 64(1), 75-85 (2002). (Pubitemid 34713233)
16. A. Luksch et al., "Effect of inhalation of different mixtures of O2 and CO2 on retinal blood flow," Br. J. Ophthalmol. 86(10), 1143-1147 (2002).
17. B. L. Justesen et al., "Retinal arterioles have impaired reactivity to hyperoxia in type 1 diabetes," Acta Ophthalmol. 88(4), 453-457 (2010).
18. S. J. Pakola and J. E. Grunwald, "Effects of oxygen and carbon dioxide on human retinal circulation," IOVS 34(10), 2866-2870 (1993). (Pubitemid 23269139)
19. W. E. Sponsel, K. L. DePaul, and S. R. Zetlan, "Retinal hemodynamic effects of carbon dioxide, hyperoxia, and mild hypoxia," IOVS 33(6), 1864-1869 (1992).
20. Y. Tamaki et al., "Acute effects of cigarette smoking on tissue circulation in human optic nerve head and choroid-retina," Ophthalmology 106(3), 564-569 (1999). (Pubitemid 30191593)
21. Y. Tamaki et al., "The acute effects of cigarette smoking on human optic nerve head and posterior fundus circulation in light smokers," Eye 14(1), 67-72 (2000). (Pubitemid 30133001)
22. R. Heitmar et al., "Continuous retinal vessel diameter measurements-the future of retinal vessel assessment?," IOVS 51(11), 5833-5839 (2010).
23. F. Tayyari et al., "The relationship between retinal vascular reactivity and arteriolar diameter in response to metabolic provocation," IOVS 50(10), 4814-4821 (2009).
24. S. T. Venkataraman et al., "Novel methodology to comprehensively assess retinal arteriolar vascular reactivity to hypercapnia," Microvasc. Res. 72, 101-107 (2006). (Pubitemid 44692752)
25. G. Garhöfer et al., "Use of the retinal vessel analyser in ocular blood flow research," Acta Ophthalmol. 88, 717-722 (2010).
26. K. Guan et al., "Retinal hemodynamics in early diabetic macular edema," Diabetes 55, 813-818 (2006). (Pubitemid 43343241)
27. C. A. Girkin, "Principles of confocal scanning laser ophthalmoscopy for the clinician," http://goo.gl/WGmq88.
28. S. Stevenson and A. Roorda, "Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy," Proc. SPIE 5688, 145-151 (2005). (Pubitemid 40953800)
29. A. Dubra and Z. Harvey, "Registration of 2D images from fast scanning ophthalmic instruments," Lec. Notes Comput. Sci. 6204, 60-71 (2010).
30. D. W. Arathorn et al., "Retinally stabilized cone-targeted stimulus delivery," Opt. Express 15, 13731-13744 (2007). (Pubitemid 47610548)
31. C. R. Vogel et al., "Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy," Opt. Express 14, 487-497 (2006). (Pubitemid 43133597)
32. J. P. Lewis, "Fast template matching," Vision Interface 10(1), 120-123 (1995).
33. N. Chapman et al., "Computer algorithms for the automated measurement of retinal arteriolar diameters," Br. J. Ophthalmol. 85(1), 74-79 (2001). (Pubitemid 32060199)
34. M. Sehi et al., "Relative magnitude of vascular reactivity in the major arterioles of the retina," Microvasc. Res. 83, 200-204 (2012).
35. C. E. Riva, J. E. Grunwald, and S. H. Sinclair, "Laser Doppler velocimetry study of the effect of pure oxygen breathing on retinal blood flow," IOVS 24(1), 47-51 (1983). (Pubitemid 13187233)
36. L. F. Schmetterer et al., "Topical measurement of fundus pulsations," Opt. Eng. 34(3), 711-716 (1995).
37. R. Cubbidge, R. J. Summers, and R. Heitmar, "Retinal vessel reactivity after cigarette smoking," Acta Ophthalmol. 90, 0-0 (2012).
38. B. Wimpissinger et al., "Effects of isometric exercise on subfoveal choroidal blood flow in smokers and nonsmokers," IOVS 44(11), 4859-4863 (2003). (Pubitemid 37315301)
39. P. B. Morgado et al., "The acute effect of smoking on retinal blood flow in subjects with and without diabetes," Ophthalmology 101, 1220-1226 (1994). (Pubitemid 24236080)
40. N. Chapman et al., "Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects," Clin. Sci. 99, 483-488 (2000). (Pubitemid 32014553)
41. T. A. Deutsch et al., "Effects of oxygen and carbon dioxide on the retinal vasculature in humans," Arch. Ophthalmol. 101(8), 1278-1280 (1983). (Pubitemid 13030949)
42. S. M. B. Rassam et al., "Regional retinal blood flow and vascular autoregulation," Eye 10, 331-337 (1996). (Pubitemid 26241503)
43. G. T. Feke et al., "Blood flow in the normal human retina," IOVS 30(1), 58-65 (1989). (Pubitemid 19039880)
44. C. E. Riva et al., "Blood velocity and volumetric flow rate in human retinal vessels," IOVS 26(8), 1124-1132 (1985). (Pubitemid 15003355)
45. H. S. Chung et al., "Regional differences in retinal vascular reactivity," IOVS 40(10), 2448-2453 (1999). (Pubitemid 29418407)
46. M. J. Mulvany and C. Aalkjaer, "Structure and function of small arteries," Physiol. Rev. 70(4), 921-961 (1990). (Pubitemid 20364819)
47. C. A. Giller et al., "Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy," Neurosurgery 32, 737-741 (1993).
48. B. Wimpissinger et al., "Response of choroidal blood flow to carbogen breathing in smokers and non-smokers," Br. J. Ophthalmol. 88(6), 776-781 (2004). (Pubitemid 38725587)
49. M. Langhans, G. Michelson, and M. J. M. Groh, " Effect of breathing 100% oxygen on retinal and optic nerve head capillary blood flow in smokers and non-smokers," Br. J. Ophthalmol. 81(5), 365-369 (1997). (Pubitemid 27271852)
50. B. Wimpissinger et al., "Response of retinal blood flow to systemic hyperoxia in smokers and nonsmokers," Graefes Arch. Clin. Exp. Ophthalmol. 243, 646-652 (2005). (Pubitemid 40975487)
51. F. Robinson, B. L. Petrig, and C. E. Riva, "The acute effect of cigarette smoking on macular capillary blood flow in humans," IOVS 26(5), 609-613 (1985). (Pubitemid 15067801)
52. R. L. Rogers et al., "The effects of chronic cigarette smoking on cerebrovascular responsiveness to 5% CO2 and 100% O2 inhalation," J. Am. Geriatr. Soc. 32(6), 415-420 (1984). (Pubitemid 14077699)
53. A. M. Zeiher, V. Schachinger, and J. Minners, "Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function," Circulation 92, 1094-1100 (1995).
54. D. S. Celermajer et al., "Cigarette smoking is associated with doserelated and potentially reversible impairment of endothelium-dependent dilation in healthy young adults," Circulation 88(5), 2149-2155 (1993). (Pubitemid 23326094)
55. D. S. Celermajer et al., "Passive smoking and impaired endotheliumdependent arterial dilation in healthy young adults," N. Engl. J. Med. 334, 150-154 (1996). (Pubitemid 26017952)
56. R. S. Barua et al., "Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation," Circulation 104, 1905-1910 (2001). (Pubitemid 32983232)
57. P. Poredos, M. Orehek, and E. Tratnik, "Smoking is associated with dose-related increase of intima-media thickness and endothelial dysfunction," Angiology 50(3), 201-208 (1999). (Pubitemid 29138426)
58. R. G. Ijzerman et al., "Cigarette smoking is associated with an acute impairment of microvascular function in humans," Clin. Sci. 104, 247-252 (2003). (Pubitemid 36308170)
59. M. M. Rahman and I. Laher, "Structural and functional alteration of blood vessels caused by cigarette smoking: an overview of molecular mechanisms," Curr. Vasc. Pharmacol. 5, 276-292 (2007).
60. J. A. Ambrose and R. S. Barua, "The pathophysiology of cigarette smoking and cardiovascular disease: an update," J. Am. Coll. Cardiol. 43(10), 1731-1737 (2004). (Pubitemid 38622506)
61. M. A. H. Talukder et al., "Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice," Am. J. Physiol.-Heart C. 300(1), 388-396 (2011).
62. J. Lekakis et al., "Effect of acute cigarette smoking on endotheliumdependent brachial artery dilation in healthy individuals," Am. J. Cardiol. 79, 529-531 (1997). (Pubitemid 127440432)
63. G. E. McVeigh et al., "Effects of long-term cigarette smoking on endothelium-dependent responses in humans," Am. J. Cardiol. 78, 668-672 (1996). (Pubitemid 126658622)