Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer

Cancer Discovery

Volumn 5, Issue 1, 2015, Pages 35-42

  Junankar, Simon ^a   Shay, Gemma ^b,f   Jurczyluk, Julie ^a   Ali, Naveid ^a   Down, Jenny ^a   Pocock, Nicholas ^a,c   Parker, Andrew ^c   Nguyen, Akira ^a   Sun, Shuting ^d   Kashemirov, Boris ^d   McKenna, Charles E ^d   Croucher, Peter I ^a   Swarbrick, Alexander ^a   Weilbaecher, Katherine ^e   Phan, Tri Giang ^a   Rogers, Michael J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c ST VINCENT S HOSPITAL   (Australia)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; ALEXA FLUOR 647; BONE DENSITY CONSERVATION AGENT; CARBOCYANINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CELL STRUCTURE; CONTROLLED STUDY; CT SPECT SCANNER; DRUG UPTAKE; ERYTHROCYTE; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIMIT OF DETECTION; MIDDLE AGED; MOLECULAR IMAGING; MOUSE; NEOPLASM; NONHUMAN; PHAGOCYTOSIS; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CALCINOSIS; TUMOR CELL; TUMOR VASCULARIZATION; ANIMAL; BREAST NEOPLASMS; CALCINOSIS; CANCER GRADING; COMPUTER ASSISTED TOMOGRAPHY; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; IMMUNOLOGY; MACROPHAGE; METABOLISM; NEOPLASMS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR INVASION;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; BREAST NEOPLASMS; CALCINOSIS; CARBOCYANINES; DIPHOSPHONATES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MACROPHAGES; MICE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASMS; PHAGOCYTOSIS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922386871     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-0621     Document Type: Article

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