Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: Application to alcohol and cardiovascular traits

International Journal of Epidemiology

Volumn 43, Issue 6, 2014, Pages 1781-1790

  Silverwood, Richard J ^a   Holmes, Michael V ^a,b   Dale, Caroline E ^a   Lawlor, Debbie A ^c,d   Whittaker, John C ^a,e   Smith, George Davey ^c,d   Leon, David A ^a   Palmer, Tom ^f   Keating, Brendan J ^g   Zuccolo, Luisa ^c,d   Casas, Juan P ^a,b   Dudbridge, Frank ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

^f UNIVERSITY OF WARWICK   (United Kingdom)

^g CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Alcohol consumption; Cardiovascular disease; Causal inference; Instrumental variables; Local average treatment effects; Mendelian randomization

Indexed keywords

ALCOHOL; ADH1B PROTEIN, HUMAN; ALCOHOL DEHYDROGENASE;

ALCOHOL; BIOMARKER; CARDIOVASCULAR DISEASE; DRINKING; ESTIMATION METHOD; GENOTYPE; NONLINEARITY;

ADH1B GENE; ALCOHOL CONSUMPTION; ARTICLE; BINARY GENOTYPE; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; DRINKING; GENE; GENETIC ASSOCIATION; GENETIC PARAMETERS; GENETIC SCREENING; GENOTYPE; HEREDITY; HUMAN; INSTRUMENTAL VARIABLE ANALYSIS; MENDELIAN RANDOMIZATION ANALYSIS; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; NON LINEAR CAUSAL EFFECT; PRIORITY JOURNAL; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; CARDIOVASCULAR DISEASES; DRINKING BEHAVIOR; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; PHENOTYPE;

ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; CARDIOVASCULAR DISEASES; CAUSALITY; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84922357503     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyu187     Document Type: Article

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