Effectiveness of TNF inhibitor treatment with various methotrexate doses in patients with rheumatoid arthritis: Results from clinical practice

Annals of the Rheumatic Diseases

Volumn 74, Issue 3, 2015, Pages e24-

  Manders, Sofie H M ^a   Kievit, Wietske ^a   Adang, Eddy ^a   Jansen, Tim J ^a   Stolk, Jan N ^b   Visser, Henk ^c   Schilder, Annemarie M ^d   Vonkeman, Harald E ^e   Van De Laar, Mart A F J ^e   Van Riel, Piet L C M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GELDERSE VALLEI HOSPITAL   (Netherlands)

^c Department of Rheumatic Diseases Radboud University Medical Center ^*  (Netherlands)

^d MEDICAL CENTER LEEUWARDEN   (Netherlands)

^e MEDISCH SPECTRUM TWENTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ETANERCEPT; INFLIXIMAB; METHOTREXATE; TUMOR NECROSIS FACTOR INHIBITOR; ANTIRHEUMATIC AGENT; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; CLINICAL PRACTICE; CONTROLLED STUDY; DAS28; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; LETTER; MALE; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; AGED; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; DRUG COMBINATION; MIDDLE AGED; REGISTER; STATISTICAL MODEL; TREATMENT OUTCOME;

ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LINEAR MODELS; MALE; METHOTREXATE; MIDDLE AGED; REGISTRIES; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84922356018     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-207005     Document Type: Letter

References (4)

1. Klareskog L, van der Heijde D, de Jager J, et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 2004; 363: 675-81.
2. van der Heijde D, Klareskog L, Rodriguez-Valverde V, et al. Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. Arthritis Rheum 2006; 54: 1063-74.
3. Breedveld FC, Weisman MH, Kavanaugh AF, et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 2006; 54: 26-37.
4. Burmester GR, Kivitz AJ, Kupper H, et al. Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial. Ann Rheum Dis 2014.