Time-related changes in the prognostic significance of the total number of examined lymph nodes in node-negative pancreatic head cancer

Journal of Surgical Oncology

Volumn 110, Issue 7, 2014, Pages 858-863

  Gleisner, Ana L ^a   Spolverato, Gaya ^b   Ejaz, Aslam ^b   Pawlik, Timothy M ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

lymph node; pancreatic cancer; prognosis

Indexed keywords

AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURGERY; CANCER SURVIVAL; FEMALE; HAZARD RATIO; HUMAN; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHATIC SYSTEM EXAMINATION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS SURGERY; PRIORITY JOURNAL; SURVIVAL TIME; TREND STUDY; ADENOCARCINOMA; CANCER REGISTRY; CANCER STAGING; COHORT ANALYSIS; FOLLOW UP; LYMPH NODE DISSECTION; MORTALITY; PANCREAS RESECTION; PANCREATIC NEOPLASMS; PATHOLOGY; PROGNOSIS; SURGERY; SURVIVAL RATE; TIME;

ADENOCARCINOMA; AGED; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; MALE; NEOPLASM STAGING; PANCREATECTOMY; PANCREATIC NEOPLASMS; PROGNOSIS; SEER PROGRAM; SURVIVAL RATE; TIME FACTORS;

EID: 84922331048     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.23715     Document Type: Article

References (36)

1. Reber HA:, Lymph node involvement as a prognostic factor in pancreatic cancer. Int J Pancreatol 1990; 7: 125-127.
2. Benassai G, Mastrorilli M, Mosella F, et al.,: Significance of lymph node metastases in the surgical management of pancreatic head carcinoma. J Exp Clin Cancer Res 1999; 18: 23-28.
3. Sohn TA, Yeo CJ, Cameron JL, et al.,: Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators. J Gastrointest Surg 2000; 4: 567-579.
4. Tomlinson JS, Jain S, Bentrem DJ, et al.,: Accuracy of staging node-negative pancreas cancer: A potential quality measure. Arch Surg 2007; 142: 723-767.
5. Huebner M, Kendrick M, Reid-Lombardo KM, et al.,: Number of lymph nodes evaluated: Prognostic value in pancreatic adenocarcinoma. J Gastrointest Surg 2012; 16: 920-926.
6. Schwarz RE, Smith DD:, Extent of lymph node retrieval and pancreatic cancer survival: Information from a large US population database. Ann Surg Oncol 2006; 13: 1189-1200.
7. Pawlik TM, Gleisner AL, Cameron JL, et al.,: Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer. Surgery 2007; 141: 610-618.
8. Slidell MB, Chang DC, Cameron JL, et al.,: Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: A large, population-based analysis. Ann Surg Oncol 2008; 15: 165-174.
9. Berger AC, Watson JC, Ross EA, et al.,: The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am Surg 2004; 70: 235-240; discussion 240.
10. Riediger H, Keck T, Wellner U, et al.,: The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer. J Gastrointest Surg 2009; 13: 1337-1344.
11. Showalter TN, Winter KA, Berger AC, et al.,: The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: A secondary analysis of RTOG 9704. Int J Radiat Oncol Biol Phys 2011; 81: 1328-1335.
12. Pomianowska E, Westgaard A, Mathisen O, et al.,: Prognostic relevance of number and ratio of metastatic lymph nodes in resected pancreatic, ampullary, and distal bile duct carcinomas. Ann Surg Oncol 2013; 20: 233-241.
13. Massucco P, Ribero D, Sgotto E, et al.,: Prognostic significance of lymph node metastases in pancreatic head cancer treated with extended lymphadenectomy: Not just a matter of numbers. Ann Surg Oncol 2009; 16: 3323-3332.
14. Bhatti I, Peacock O, Awan AK, et al.,: Lymph node ratio versus number of affected lymph nodes as predictors of survival for resected pancreatic adenocarcinoma. World J Surg 2010; 34: 768-775.
15. Parsons HM, Tuttle TM, Kuntz KM, et al.,: Association between lymph node evaluation for colon cancer and node positivity over the past 20 years. JAMA 2011; 306: 1089-1097.
16. Shia J, Wang H, Nash GM, et al.,: Lymph node staging in colorectal cancer: Revisiting the benchmark of at least 12 lymph nodes in R0 resection. J Am Coll Surg 2012; 214: 348-355.
17. Gleisner AL, Mogal H, Dodson R, et al.,: Nodal status, number of lymph nodes examined, and lymph node ratio: What defines prognosis after resection of colon adenocarcinoma ? J Am Coll Surg 2013; 217: 1090-1100.
18. Yamashita H, Katai H, Morita S, et al.,: Optimal extent of lymph node dissection for Siewert type II esophagogastric junction carcinoma. Ann Surg 2011; 254: 274-280.
19. van der Wal BC, Butzelaar RM, van der Meij S, et al.,: Axillary lymph node ratio and total number of removed lymph nodes: Predictors of survival in stage I and II breast cancer. Eur J Surg Oncol 2002; 28: 481-489.
20. Ino Y, Yamazaki-Itoh R, Shimada K, et al.,: Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br J Cancer 2013; 108: 914-923.
21. Schwitalle Y, Kloor M, Eiermann S, et al.,: Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterology 2008; 134: 988-997.
22. Bilimoria KY, Talamonti MS, Wayne JD, et al.,: Effect of hospital type and volume on lymph node evaluation for gastric and pancreatic cancer. Arch Surg 2008; 143: 671-678; discussion 678.
23. Pedrazzoli S, DiCarlo V, Dionigi R, et al.,: Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: A multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg 1998; 228: 508-517.
24. Farnell MB, Pearson RK, Sarr MG, et al.,: A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 2005; 138: 618-628 discussion 628-630.
25. Yeo CJ, Cameron JL, Lillemoe KD, et al.,: Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: Randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 2002; 236: 355-366; discussion 358-366.
26. Nimura Y, Nagino M, Takao S, et al.,: Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: Long-term results of a Japanese multicenter randomized controlled trial. J Hepatobiliary Pancreat Sci 2012; 19: 230-241.
27. Michalski CW, Kleeff J, Wente MN, et al.,: Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer. Br J Surg 2007; 94: 265-273.
28. Iqbal N, Lovegrove RE, Tilney HS, et al.,: A comparison of pancreaticoduodenectomy with extended pancreaticoduodenectomy: A meta-analysis of 1909 patients. Eur J Surg Oncol 2009; 35: 79-86.
29. Rupp CC, Linehan DC:, Extended lymphadenectomy in the surgery of pancreatic adenocarcinoma and its relation to quality improvement issues. J Surg Oncol 2009; 99: 207-214.
30. Fielding LP, Arsenault PA, Chapuis PH, et al.,: Clinicopathological staging for colorectal cancer: An International Documentation System (IDS) and an International Comprehensive Anatomical Terminology (ICAT). J Gastroenterol Hepatol 1991; 6: 325-344.
31. NCCN Clinical Practice Guidelines in Oncology: Pancreatic adenocarcinoma. Version 1. 2013.
32. Surveillance Research Program, NCI: Surveillance, epidemiology, and end results program. Available at seer.cancer.gov
33. Falconi M, Crippa S, Dominguez I, et al.,: Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma. Ann Surg Oncol 2008; 15: 3178-3186.
34. Bilimoria KY, Bentrem DJ, Stewart AK, et al.,: Lymph node evaluation as a colon cancer quality measure: A national hospital report card. J Natl Cancer Inst 2008; 100: 1310-1317.
35. Bilimoria KY, Talamonti MS, Sener SF, et al.,: Effect of hospital volume on margin status after pancreaticoduodenectomy for cancer. J Am Coll Surg 2008; 207: 510-519.
36. Millikan KW, Deziel DJ, Silverstein JC, et al.,: Prognostic factors associated with resectable adenocarcinoma of the head of the pancreas. Am Surg 1999; 65: 618-623; discussion 614-623.