Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models

Human molecular genetics

Volumn 23, Issue 23, 2014, Pages 6212-6222

  Li, Tianxia ^a   Yang, Dejun ^a   Zhong, Shijun ^a   Thomas, Joseph M ^a   Xue, Fengtian ^a   Liu, Jingnan ^a   Kong, Lingbo ^a   Voulalas, Pamela ^a   Hassan, Hazem E ^a   Park, Jae Sung ^a   MacKerell, Alexander D ^a   Smith, Wanli W ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE; LIPOPOLYSACCHARIDE; LRRK1 PROTEIN, HUMAN; LRRK2 PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SULFONE; THIAZOLE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CELL CULTURE; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; INFLAMMATION; METABOLISM; MICROGLIA; MOUSE; MUTATION; NERVE CELL; PARKINSON DISEASE; PATHOLOGY; PHOSPHORYLATION; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GUANOSINE TRIPHOSPHATE; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; MICROGLIA; MUTATION; NEURONS; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SULFONES; THIAZOLES;

EID: 84922239503     PISSN: None     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu341     Document Type: Article

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