Increasing varenicline dose in smokers who do not respond to the standard dosage a randomized clinical trial

JAMA Internal Medicine

Volumn 175, Issue 2, 2015, Pages 266-271

  Hajek, Peter ^a   McRobbie, Hayden ^a   Smith, Katherine Myers ^a   Phillips, Anna ^a   Cornwall, Danielle ^a   Dhanji, Al Rehan ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; PLACEBO; VARENICLINE; BENZAZEPINE DERIVATIVE; NICOTINIC AGENT; QUINOXALINE DERIVATIVE;

ABNORMAL DREAMING; ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DECREASED APPETITE; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DYSGEUSIA; FATIGUE; FEMALE; FLATULENCE; FOLLOW UP; HEADACHE; HUMAN; INSOMNIA; LETHARGY; MAJOR CLINICAL STUDY; MALE; NAUSEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SLEEP DISORDER; SMOKING; SMOKING CESSATION; TREATMENT DURATION; TREATMENT RESPONSE; VOMITING; WITHDRAWAL SYNDROME; DRUG THERAPY; MIDDLE AGED; PROCEDURES; STATISTICS AND NUMERICAL DATA; TREATMENT FAILURE;

ADULT; BENZAZEPINES; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINIC AGONISTS; QUINOXALINES; SMOKING; SMOKING CESSATION; TREATMENT FAILURE; VARENICLINE;

EID: 84922214301     PISSN: 21686106     EISSN: 21686114     Source Type: Journal    
DOI: 10.1001/jamainternmed.2014.6916     Document Type: Article

References (17)

1. West R, Baker CL, Cappelleri JC, Bushmakin AG. Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology (Berl). 2008;197(3):371-377
2. Gonzales D, Rennard SI, NidesM, et al; Varenicline Phase 3 Study Group. Varenicline, an 42 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation. JAMA. 2006;296 (1):47-55
3. Jorenby DE, Hays JT, Rigotti NA, et al; Varenicline Phase 3 Study Group. Efficacy of varenicline, an 42 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation. JAMA. 2006;296(1):56-63
4. Aubin HJ, Bobak A, Britton JR, et al. Varenicline versus transDermal nicotine patch for smoking cessation. Thorax. 2008;63(8):717-724
5. Hajek P, McRobbie HJ, Myers KE, Stapleton J, Dhanji AR. Use of varenicline for 4 weeks before quitting smoking: decrease in ad lib smoking and increase in smoking cessation rates. Arch Intern Med. 2011;171(8):770-777
6. Faessel HM, Smith BJ, Gibbs MA, Gobey JS, Clark DJ, Burstein AH. Single-dose pharmacokinetics of varenicline, a selective nicotinic receptor partial agonist, in healthy smokers and nonsmokers. J Clin Pharmacol. 2006;46(9):991-998
7. Faessel HM, Gibbs MA, Clark DJ, Rohrbacher K, Stolar M, Burstein AH. Multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers. J Clin Pharmacol. 2006;46(12):1439-1448
8. Rollema H, Faessel HM, Williams KE. Varenicline overdose in a teenager. Clin Toxicol (Phila). 2009;47 (6):605
9. Jimez-Ruiz CA, BarriosM, Pe S, et al. Increasing the dose of varenicline in patients who do not respond to the standard dose. Mayo Clin Proc. 2013;88(12):1443-1445
10. Hedlund AJ, BroDerickM, Shah N, Cantrell L. Varenicline overdose in a teenager. Clin Toxicol (Phila). 2009;47(4):371
11. McEwan A, Hajek P, McRobbie H,West R. Manual of Smoking Cessation: A Guide for Counsellors and Practitioners. Oxford, England: Wiley-Blackwell; 2006
12. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstr KO. The Fagerstr Test for Nicotine Dependence: a revision of the Fagerstr Tolerance Questionnaire. Br J Addict. 1991;86(9): 1119-1127
13. West R, Hajek P. Evaluation of the Mood and Physical Symptoms Scale (MPSS) to assess cigarette withdrawal. Psychopharmacology (Berl). 2004;177 (1-2):195-199
14. West R, Hajek P, Burrows S. Effect of glucose tablets on craving for cigarettes. Psychopharmacology (Berl). 1990;101(4):555-559
15. McRobbie H, Hajek P. Effects of rapid smoking on post-cessation urges to smoke. Addiction. 2007; 102(3):483-489
16. West R, Hajek P, Stead L, Stapleton J. Outcome criteria in smoking cessation trials. Addiction. 2005; 100(3):299-303
17. Niaura R, Hays JT, Jorenby DE, et al. The efficacy and safety of varenicline for smoking cessation using a flexible dosing strategy in adult smokers. Curr Med Res Opin. 2008;24(7):1931-1941