Tramadol and hypoglycemia one more thing toworry about

JAMA Internal Medicine

Volumn 175, Issue 2, 2015, Pages 194-195

  Nelson, Lewis S ^a   Juurlink, David N ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; GLUCOSE; OPIATE; PAROXETINE; TRAMADOL; NARCOTIC ANALGESIC AGENT;

ANALGESIA; BRAIN CORTEX; CHRONIC PAIN; GLUCONEOGENESIS; GLUCOSE UTILIZATION; HOSPITAL ADMISSION; HUMAN; HYPOGLYCEMIA; HYPOTHALAMUS; MEDICAL RECORD; NONHUMAN; NOTE; PRESCRIPTION; PRIORITY JOURNAL; UNITED KINGDOM; CHEMICALLY INDUCED; FEMALE; MALE; PAIN;

ANALGESICS, OPIOID; FEMALE; HUMANS; HYPOGLYCEMIA; MALE; PAIN; TRAMADOL;

EID: 84922210875     PISSN: 21686106     EISSN: 21686114     Source Type: Journal    
DOI: 10.1001/jamainternmed.2014.5260     Document Type: Note

References (7)

1. Kirchheiner J, Keulen JT, Bauer S, Roots I, Brockmller J. Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J Clin Psychopharmacol. 2008;28(1):78-83
2. Babalonis S, Lofwall MR, Nuzzo PA, Siegel AJ, Walsh SL. Abuse liability and reinforcing efficacy of oral tramadol in humans. Drug Alcohol Depend. 2013;129(1-2):116-124
3. Erowid Experience Vaults. Tramadol. http://www.erowid.org/experiences/subs/exp-Pharms-Tramadol.shtml. Accessed September 15, 2014
4. Office for National Statistics. Deaths Related to Drug Poisoning, England and Wales-2013. http://www.ons.gov.uk/ons/rel/subnational-health3/deaths-related-to-drug-poisoning/england-And-wales-2013/index.html. Accessed September 15, 2014
5. Fournier J-P, Azoulay L, Yin H, Montastruc J-L, Suissa S. Tramadol use and the risk of hospitalization for hypoglycemia in patients with noncancer pain [published online December 8, 2014]. JAMA Intern Med. doi:10.1001/jamainternmed.2014.6512
6. Cheng JT, Liu IM, Chi TC, Tzeng TF, Lu FH, Chang CJ. Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats. Diabetes. 2001;50(12):2815-2821
7. Choi SB, Jang JS, Park S. Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats. Brain Res Bull. 2005;67(1-2):77-86