The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity

Dental Materials Journal

Volumn 34, Issue 1, 2015, Pages 31-40

  Lochaiwatana, Yossakit ^a   Poolthong, Suchit ^a   Hirata, Isao ^b   Okazaki, Masayuki ^b   Swasdison, Somporn ^a   Vongsavan, Noppakun ^c  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b HIROSHIMA UNIVERSITY   (Japan)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Dentin hypersensitivity; Dentin permeability; Fluoridated hydroxyapatite; Potassium chloride; Varnish

Indexed keywords

BIOCOMPATIBILITY; CELL CULTURE; CHARACTERIZATION; CHLORINE COMPOUNDS; CYTOTOXICITY; FLUORINE COMPOUNDS; HYDROXYAPATITE; IONS; POTASH; SCANNING ELECTRON MICROSCOPY; VARNISH;

CYTOTOXICITY TEST; DENTIN HYPERSENSITIVITY; DENTINAL TUBULES; FLUORIDATED HYDROXYAPATITE; HYDRAULIC CONDUCTANCE; POTENTIAL MATERIALS; SCANNING ELECTRON MICROSCOPY IMAGE; SYNTHESIS AND CHARACTERIZATIONS;

POTASSIUM CHLORIDE;

DESENSITIZING AGENT; FLUOR-HYDROXYLAPATITE; FLUORIDE VARNISH; HYDROXYAPATITE; POTASSIUM CHLORIDE; SODIUM FLUORIDE; SODIUM FLUORIDE TOPICAL PREPARATION;

CHEMISTRY; CYTOLOGY; DENTIN PERMEABILITY; DENTIN SENSITIVITY; DRUG EFFECTS; FIBROBLAST; GINGIVA; HUMAN; IN VITRO STUDY; MATERIALS TESTING; SCANNING ELECTRON MICROSCOPY; SYNTHESIS; TOOTH PULP; TOXICITY TESTING;

DENTAL PULP; DENTIN DESENSITIZING AGENTS; DENTIN PERMEABILITY; DENTIN SENSITIVITY; FIBROBLASTS; FLUORIDES, TOPICAL; GINGIVA; HUMANS; HYDROXYAPATITES; IN VITRO TECHNIQUES; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; POTASSIUM CHLORIDE; SODIUM FLUORIDE; TOXICITY TESTS;

EID: 84922182856     PISSN: 02874547     EISSN: 18811361     Source Type: Journal    
DOI: 10.4012/dmj.2014-102     Document Type: Article

References (46)

1. Rees JS, Jin LJ, Lam S, Kudanowska I, Vowles R. The prevalence of dentine hypersensitivity in a hospital clinic population in Hong Kong. J Dent 2003; 31: 453-461.
2. Taani DQ, Awartani F. Prevalence and distribution of dentin hypersensitivity and plaque in a dental hospital population. Quintessence Int 2001; 32: 372-376.
3. Bartold PM. Dentinal hypersensitivity: a review. Aust Dent J 2006; 51: 212-218; quiz 276.
4. Ritter AV, de LDW, Miguez P, Caplan DJ, Swift EJ, Jr. Treating cervical dentin hypersensitivity with fluoride varnish: a randomized clinical study. J Am Dent Assoc 2006; 137: 1013-1020; quiz 1029.
5. Addy M. Etiology and clinical implications of dentine hypersensitivity. Dent Clin North Am 1990; 34: 503-514.
6. Bekes K, John MT, Schaller HG, Hirsch C. Oral healthrelated quality of life in patients seeking care for dentin hypersensitivity. J Oral Rehabil 2009; 36: 45-51.
7. Braennstroem M, Astroem A. A study on the mechanism of pain elicited from the dentin. J Dent Res 1964; 43: 619-625.
8. Pashley DH. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med 1996; 7: 104-133.
9. Chidchuangchai W, Vongsavan N, Matthews B. Sensory transduction mechanisms responsible for pain caused by cold stimulation of dentine in man. Arch Oral Biol 2007; 52: 154-160.
10. Orchardson R, Gillam DG. The efficacy of potassium salts as agents for treating dentin hypersensitivity. J Orofac Pain 2000; 14: 9-19.
11. Markowitz K, Bilotto G, Kim S. Decreasing intradental nerve activity in the cat with potassium and divalent cations. Arch Oral Biol 1991; 36: 1-7.
12. Poulsen S, Errboe M, Lescay Mevil Y, Glenny AM. Potassium containing toothpastes for dentine hypersensitivity. Cochrane Database Syst Rev 2006: CD001476.
13. Kishore A, Mehrotra KK, Saimbi CS. Effectiveness of desensitizing agents. J Endod 2002; 28: 34-35.
14. Frechoso SC, Menendez M, Guisasola C, Arregui I, Tejerina JM, Sicilia A. Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial. J Clin Periodontol 2003; 30: 315-320.
15. Hodosh M, Hodosh SH, Hodosh AJ. KNO3/benzocaine/ tetracaine gel use for maintenance visit pain control. Gen Dent 2007; 55: 312-315.
16. Suge T, Kawasaki A, Ishikawa K, Matsuo T, Ebisu S. Effects of ammonium hexafluorosilicate concentration on dentin tubule occlusion and composition of the precipitate. Dent Mater 2010; 26: 29-34.
17. Shetty S, Kohad R, Yeltiwar R. Hydroxyapatite as an inoffice agent for tooth hypersensitivity: a clinical and scanning electron microscopic study. J Periodontol 2010; 81: 1781-1789.
18. Suge T, Kawasaki A, Ishikawa K, Matsuo T, Ebisu S. Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion. Dent Mater 2008; 24: 192-198.
19. Mukai Y, Tomiyama K, Okada S, Mukai K, Negishi H, Fujihara T. Dentinal tubule occlusion with lanthanum fluoride and powdered apatite glass ceramics in vitro. Dent Mater J 1998; 17: 253-263.
20. Tomiyama K, Mukai Y, Okada S, Negishi H, Fujihara T, Kawase T, Ueda M, Nakagawa S, Teranaka T. Durability of FTLA treatment as a medicament for dentin hypersensitivity--abrasion resistance and profiles of fluoride release. Dent Mater J 2004; 23: 585-592.
21. Brannstrom M. The cause of postrestorative sensitivity and its prevention. J Endod 1986; 12: 475-481.
22. Wycoff SJ. Current treatment for dentinal hypersensitivity. In-office treatment. Compend Contin Educ Dent 1982: S113-115.
23. Pashley DH, O'Meara JA, Williams EC, Kepler EE. Dentin permeability: effects of cavity varnishes and bases. J Prosthet Dent 1985; 53: 511-516.
24. Corona SA, Nascimento TN, Catirse AB, Lizarelli RF, Dinelli W, Palma-Dibb RG. Clinical evaluation of low-level laser therapy and fluoride varnish for treating cervical dentinal hypersensitivity. J Oral Rehabil 2003; 30: 1183-1189.
25. Gaffar A. Treating hypersensitivity with fluoride varnish. Compend Contin Educ Dent 1999; 20: 27-33; quiz 35.
26. Gaffar A. Treating hypersensitivity with fluoride varnishes. Compend Contin Educ Dent 1998; 19: 1088-1090, 1092, 1094 passim.
27. Clark DC, Hanley JA, Geoghegan S, Vinet D. The effectiveness of a fluoride varnish and a desensitizing toothpaste in treating dentinal hypersensitivity. J Periodontal Res 1985; 20: 212-219.
28. Mazor Z, Brayer L, Friedman M, Steinberg D. Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity. Clin Prev Dent 1991; 13: 21-25.
29. Zhang Q, van 't Hof MA, Truin GJ, Bronkhorst EM, van Palenstein Helderman WH. Caries-inhibiting effect of chlorhexidine varnish in pits and fissures. J Dent Res 2006; 85: 469-472.
30. Czerninski R, Sivan S, Steinberg D, Gati I, Kagan L, Friedman M. A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. Clin Oral Investig 2010; 14: 71-78.
31. Matthijs S, Adriaens PA. Chlorhexidine varnishes: a review. J Clin Periodontol 2002; 29: 1-8.
32. Grossman LI. A systematic method for the treatment of hypersensitive dentine. J Am Dent Assoc 1935; 22: 592-598.
33. McFall WT, Jr. A review of the active agents available for treatment of dentinal hypersensitivity. Endod Dent Traumatol 1986; 2: 141-149.
34. Miglani S, Aggarwal V, Ahuja B. Dentin hypersensitivity: Recent trends in management. J Conserv Dent 2010; 13: 218-224.
35. Tian L, Peng C, Shi Y, Guo X, Zhong B, Qi J, Wang G, Cai Q, Cui F. Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis. Dent Mater J 2014; 33: 125-132.
36. Lee BS, Kang SH, Wang YL, Lin FH, Lin CP. In vitro study of dentinal tubule occlusion with sol-gel DP-bioglass for treatment of dentin hypersensitivity. Dent Mater J 2007; 26: 52-61.
37. Okazaki M, Aoba T, Doi Y, Takahashi J, Moriwaki Y. Solubility and crystallinity in relation to fluoride content of fluoridated hydroxyapatites. J Dent Res 1981; 60: 845-849.
38. Shen C, Autio-Gold J. Assessing fluoride concentration uniformity and fluoride release from three varnishes. J Am Dent Assoc 2002; 133: 176-182.
39. Nakabayashi N, Saimi Y. Bonding to intact dentin. J Dent Res 1996; 75: 1706-1715.
40. Greenhill JD, Pashley DH. The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. J Dent Res 1981; 60: 686-698.
41. Okazaki M, Miake Y, Tohda H, Yanagisawa T, Takahashi J. Fluoridated apatite synthesized using a multi-step fluoride supply system. Biomaterials 1999; 20: 1303-1307.
42. Hack GD, Thompson VP. Occlusion of dentinal tubules with cavity varnishes. Archs Oral Biol 1994; 39: 149.
43. Gangarosa LP, Sr. Current strategies for dentist-applied treatment in the management of hypersensitive dentine. Arch Oral Biol 1994; 39 Suppl: 101S-106S.
44. Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc 2006; 137: 990-998; quiz 1028-1029.
45. Kara C, Orbak R. Comparative evaluation of Nd:YAG laser and fluoride varnish for the treatment of dentinal hypersensitivity. J Endod 2009; 35: 971-974.
46. Kielbassa AM, Attin T, Hellwig E, Schade-Brittinger C. In vivo study on the effectiveness of a lacquer containing CaF2/ NaF in treating dentine hypersensitivity. Clin Oral Investig 1997; 1: 95-99.