Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations

International Journal of Cancer

Volumn 136, Issue 6, 2015, Pages E559-E568

  Kraus, Cornelia ^a   Rau, Tilman T ^a   Lux, Philipp ^a   Erlenbach Wünsch, Katharina ^a   Löhr, Sabine ^a   Krumbiegel, Mandy ^a   Thiel, Christian T ^a   Stöhr, Robert ^a   Agaimy, Abbas ^a   Croner, Roland S ^a   Stürzl, Michael ^a   Hohenberger, Werner ^a   Hartmann, Arndt ^a   Reis, André ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Colorectal cancer; Gene panel; Next generation sequencing; Unbiased

Indexed keywords

APC PROTEIN; B RAF KINASE; GLUTAMIC ACID; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MSH6; VALINE; BRAF PROTEIN, HUMAN; DNA; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; AGED; APC GENE; ARTICLE; BRAF GENE; CARCINOGENICITY; COLORECTAL CANCER; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; FRAMESHIFT MUTATION; GENE; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; MLH1 GENE; MLH3 GENE; MSH2 GENE; MSH3 GENE; MSH6 GENE; NEXT GENERATION SEQUENCING; NONSENSE MUTATION; PENETRANCE; SOMATIC MUTATION; COLORECTAL TUMOR; DNA METHYLATION; GENETICS; MIDDLE AGED; MISMATCH REPAIR; MUTATION; PATHOLOGY; PROSPECTIVE STUDY; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA MISMATCH REPAIR; DNA, NEOPLASM; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 84922146048     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29149     Document Type: Article

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