Ligand-directed stearic acid grafted chitosan micelles to increase therapeutic efficacy in hepatic cancer

Molecular Pharmaceutics

Volumn 12, Issue 2, 2015, Pages 644-652

  Yang, Yuan ^a   Yuan, Sheng Xian ^a   Zhao, Ling Hao ^a   Wang, Chao ^a   Ni, Jun Sheng ^a   Wang, Zhen Guang ^a   Lin, Chuan ^a   Wu, Meng Chao ^a   Zhou, Wei Ping ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Innovation Alliance for Hepatitis and Liver Cancer   (China)

Author keywords

antitumor efficacy; apoptosis; doxorubicin; lactobionic acid; polymeric micelles

Indexed keywords

CHITOSAN; DOXORUBICIN; LACTOBIONIC ACID; NANOCARRIER; STEARIC ACID; DISACCHARIDE; DRUG CARRIER; MICELLE; POLYMER; STEARIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL MEMBRANE; CELL STRUCTURE; CHROMATIN CONDENSATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG TARGETING; DRUG TISSUE LEVEL; DRUG UPTAKE; FLOW CYTOMETRY; HEPG2 CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER CANCER; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; MICELLE; MORPHOLOGY; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR REGRESSION; TUMOR XENOGRAFT; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG SCREENING; LIVER NEOPLASMS; NUDE MOUSE; PROCEDURES; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHITOSAN; DISACCHARIDES; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICE, NUDE; MICELLES; POLYMERS; STEARIC ACIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922112597     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500723k     Document Type: Article

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