Severe hypoglycemia and coronary artery calcification during the diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC) study

Diabetes Research and Clinical Practice

Volumn 107, Issue 2, 2015, Pages 280-289

  Fährmann, Elke R ^a   Adkins, Laura ^b   Loader, Cameron J ^b   Han, Hyoil ^b   Rice, Kevin M ^a   Denvir, James ^a   Driscoll, Henry K ^a,c  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MARSHALL UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cardiovascular disease; Coronary artery calcification; DCCT EDIC study; Severe hypoglycemia; Type 1 diabetes

Indexed keywords

ALBUMIN; HEMOGLOBIN A1C; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

ADOLESCENT; ADULT; AGE; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CLINICAL FEATURE; COHORT ANALYSIS; CORONARY ARTERY CALCIFICATION; CORRELATIONAL STUDY; DIABETIC NEUROPATHY; DISEASE DURATION; DISEASE SEVERITY; EXCRETION; FEMALE; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; RISK ASSESSMENT; SEX DIFFERENCE; SMOKING; SYSTOLIC BLOOD PRESSURE; ATHEROSCLEROSIS; BLOOD; CALCINOSIS; COMPLICATION; CORONARY ARTERY DISEASE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DISEASE MANAGEMENT; FOLLOW UP; GLUCOSE BLOOD LEVEL; METABOLISM; PREVALENCE; RETROSPECTIVE STUDY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADOLESCENT; ADULT; ATHEROSCLEROSIS; BLOOD GLUCOSE; CALCINOSIS; COHORT STUDIES; CORONARY ARTERY DISEASE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DISEASE MANAGEMENT; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; PREVALENCE; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84922019132     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2014.10.007     Document Type: Article

References (50)

1. Soedamah-Muthu S.S., Fuller J.H., Mulnier H.E., Raleigh V.S., Lawrenson R.A., Colhoun H.M. High risk of cardiovascular disease in patients with type 1 diabetes in the U.K.: a cohort study using the general practice research database. Diabetes Care 2006, 29:798-804.
2. Laing S.P., Swerdlow A.J., Slater S.D., Burden A.C., Morris A., Waugh N.R., et al. Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes. Diabetologia 2003, 46:760-765.
3. Orchard T.J., Costacou T., Kretowski A., Nesto R.W. Type 1 diabetes and coronary artery disease. Diabetes Care 2006, 29:2528-2538.
4. The DCCT Research Group, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329:977-986.
5. Nathan D.M., Cleary P.A., Backlund J.Y., Genuth S.M., Lachin J.M., Orchard T.J., Raskin P., et al. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005, 353:2643-2653.
6. The DCCT Research Group, Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003; 290:2159-2167.
7. The DCCT Research Group, Adverse events and their association with treatment regimens in the diabetes control and complications trial. Diabetes Care 1995; 18:1415-1427.
8. The DCCT Research Group, Hypoglycemia in the Diabetes Control and Complications Trial. Diabetes 1997; 46:271-286.
9. Ahrén B. Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes. Vasc Health Risk Manag 2013, 9:155-163.
10. Holt P. Taking hypoglycaemia seriously: diabetes, dementia and heart disease. Br J Community Nurs 2011, 16:246-249.
11. Castaldo E., Sabato D., Lauro D., Sesti G., Marini M.A. Hypoglycemia assessed by continuous glucose monitoring is associated with preclinical atherosclerosis in individuals with impaired glucose tolerance. PLoS One 2011, 6:e28312.
12. Wright R.J., Frier B.M. Vascular disease and diabetes: is hypoglycaemia an aggravating factor?. Diabetes Metab Res Rev 2008, 24:353-363.
13. Opie L.H., Yellon D.M., Gersh B.J. Controversies in the cardiovascular management of type 2 diabetes. Heart 2011, 97:6-14.
14. Johnston S.S., Conner C., Aagren M., Smith D.M., Bouchard J., Brett J. Evidence linking hypoglycemic events to an increased risk of acute cardiovascular events in patients with type 2 diabetes. Diabetes Care 2011, 34:1164-1170.
15. Snell-Bergeon J.K., Wadwa R.P. Hypoglycemia, diabetes, and cardiovascular disease. Diabetes Technol Ther 2012, 14(Suppl 1):S51-S58.
16. Vigersky R. Mad about "U". J Clin Endocrinol Metab 2014, 99:771-773.
17. Gruden G., Barutta F., Chaturvedi N., Schalkwijk C., Stehouwer C.D., Witte D.R., et al. Severe hypoglycemia and cardiovascular disease incidence in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 2012, 35:1598-1604.
18. Giménez M., Gilabert R., Monteagudo J., Alonso A., Casamitjana R., Pare C., et al. Repeated episodes of hypoglycemia as a potential aggravating factor for preclinical atherosclerosis in subjects with type 1 diabetes. Diabetes Care 2011, 34:198-203.
19. Giménez M., López J.J., Castell C., Conget I. Hypoglycaemia and cardiovascular disease in type 1 diabetes. Results from the Catalan National Public Health registry on insulin pump therapy. Diabetes Res Clin Pract 2012, 96:e23-e25.
20. Gruden G., Barutta F., Perin P., Bruno G. Response to Comment on: Gruden et al. Severe Hypoglycemia and Cardiovascular Disease Incidence in Type 1 Diabetes: The EURODIAB Prospective Complications Study. Diabetes Prospective Complications Study. Diabetes Care 2012; 35:1598-1604 (letter). Diabetes Care 2012, 35:e89.
21. Giménez M., Conget I. Comment on: Gruden et al. Severe hypoglycemia and cardiovascular disease incidence in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 2012;35:1598-1604 (letter). Diabetes Care 2012, 35:e88.
22. Yamagishi S.I., Edelstein D., Du X.L., Brownlee M. Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes 2001, 50:1491-1494.
23. Funk S.D., Yurdagul A., Orr A.W. Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes. Int J Vasc Med 2012, 569654.
24. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005, 54:1615-1625.
25. Dalsgaard-Nielsen J., Madsbad S., Hilsted J. Changes in platelet function, blood coagulation and fibrinolysis during insulin-induced hypoglycaemia in juvenile diabetics and normal subjects. Thromb Haemost 1982, 47:254-258.
26. Fisher B.M., Hepburn D.A., Smith J.G., Frier B.M. Responses of peripheral blood cells to acute insulin-induced hypoglycaemia in humans: effect of alpha-adrenergic blockade. Horm Metab Res Suppl 1992, 26:109-110.
27. Wright R.J., Newby D.E., Stirling D., Ludlam C.A., Macdonald I.A., Frier B.M. Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes. Diabetes Care 2010, 33:1591-1597.
28. Dandona P., Chaudhuri A., Dhindsa S. Proinflammatory and Prothrombotic Effects of Hypoglycemia. Diabetes Care 2010, 33:1686-1687.
29. Desouza C.V., Bolli G.B., Fonseca V. Hypoglycemia, diabetes, and cardiovascular events. Diabetes Care 2010, 33:1389-1394.
30. Nakagami H., Kaneda Y., Ogihara T., Morishita R. Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Curr Diabetes Rev 2005, 1:59-63.
31. Davignon J., Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004, 109(suppl III):III-27-III-32.
32. Agarwal S., Cox A.J., Herrington D.M., Jorgensen N.W., Xu J., Freedman B.I., et al. Coronary calcium score predicts cardiovascular mortality in diabetes: diabetes heart study. Diabetes Care 2013, 36:972-977.
33. Kramer C.K., Zinman B., Gross J.L., Canani L.H., Rodrigues T.C., Azevedo M.J., et al. Coronary artery calcium score prediction of all-cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis. BMJ 2013, 346:f1654.
34. Greenland P., Bonow R.O., Brundage B.H., et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 2007, 49:378-402.
35. Hoffmann U., Brady T.J., Muller J. Cardiology patient page. Use of new imaging techniques to screen for coronary artery disease. Circulation 2003, 108:e50-e53.
36. Cleary P.A., Orchard T.J., Genuth S., Wong N.D., Detrano R., Backlund J.Y., et al. The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes 2006, 55:3556-3565.
37. Manual of Operations for the Diabetes Control and Complications Trial 1987, DCCT Research Group, Department of Commerce, Washington, DC, US.
38. Epidemiology of Diabetes Interventions and Complications Protocol and Manual of Operations 2010, EDIC Data Coordinating Center, Biostatistics Center, The George Washington University, Washington, DC, amended December 2010.
39. National Institute for Clinical Excellence. 2002. Available at:. http://www.nice.org.uk/.
40. Morioka T., Emoto M., Tabata T., Shoji T., Tahara H., Kishimoto H., et al. Glycemic control is a predictor of survival for diabetic patients on hemodialysis. Diabetes Care 2001, 24:909-913.
41. Rewers M., Pihoker C., Donaghue K., Hanas R., Swift P., Klingensmith G.J. Assessment and monitoring of glycemic control in children and adolescents with diabetes. ISPAD Clinical Practice Consensus Guidelines, 2006-2007. Pediatr Diabet 2007, 8:408-418.
42. Snell-Bergeon J.K., Hokanson J.E., Jensen L., MacKenzie T., Kinney G., Dabelea D., et al. Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control. Diabetes Care 2003, 26:2923-2928.
43. Lachin J. The Assessment of Relative Risks. Biostatistical Methods 2000, John Wiley and Sons.
44. White N.H., Cleary P.A., Dahms W., Goldstein D., Malone J., Tamborlane W.V. Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr 2001, 139:804-812.
45. Lopes-Virella M.F., Baker N.L., Hunt K.J., Lachin J., Nathan D., Virella G., Group D.E.R. Oxidized LDL immune complexes and coronary artery calcification in type 1 diabetes. Atherosclerosis 2011, 214:462-467.
46. Aguilera E., Serra E., Granada M., Alonso N., Pellitero S., Pizarro E., Reverter J., et al. Low prevalence of subclinical atherosclerosis in asymptomatic patients with Type 1 Diabetes in a European Mediterranean population diabetes care 2014, 37:814-820.
47. Zou G. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004, 159:702-706.
48. Lipska K.J., Warton E.M., Huang E.S., Moffet H.H., Inzucchi S.E., Krumholz H., et al. HbA1c and risk of severe hypoglycemia in type 2 diabetes: the Diabetes and Aging study. Diabetes Care 2013, 36:3535-3542.
49. Currie C.J., Peters J.R., Tynan A., Evans M., Heine R.J., Bracco O.L., Zagar T., Poole C.D. Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study. Lancet 2010, 375:481-489.
50. Schoenaker D.A., Simon D., Chaturvedi N., Fuller J.H., Soedamah-Muha S.S. Glycemic control and all-cause mortality risk in type 1 diabetes patients: the EURODIAB Prospective Complications Study. J Clin Endocrinol Metab 2014, 99:800-807.