Clarifying the impact of polycomb complex component disruption in human cancers

Molecular Cancer Research

Volumn 12, Issue 4, 2014, Pages 479-484

  Yamamoto, Yukiya ^a   Abe, Akihiro ^a   Emi, Nobuhiko ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; HISTONE H2A; POLYCOMB GROUP PROTEIN; PROTEIN BCL 6; RETINOIC ACID RECEPTOR ALPHA; RING FINGER PROTEIN; BCORL1 PROTEIN, HUMAN; CCNB3 PROTEIN, HUMAN; CYCLIN B; DNA BINDING PROTEIN; ELF4 PROTEIN, HUMAN; ONCOPROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; CANCER DIAGNOSIS; CANCER PROGNOSIS; CHRONIC MYELOMONOCYTIC LEUKEMIA; GENE MUTATION; HUMAN; LIVER CELL CARCINOMA; MEDULLOBLASTOMA; MICROPHTHALMIA; MYELODYSPLASTIC SYNDROME; OSTEOSARCOMA; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; RETINOBLASTOMA; REVIEW; SEQUENCE ANALYSIS; TREATMENT RESPONSE; TUMOR SUPPRESSOR GENE; UBIQUITINATION; FEMALE; GENETICS; GERMLINE MUTATION; MALE; NEOPLASM;

CYCLIN B; DNA-BINDING PROTEINS; FEMALE; GENES, TUMOR SUPPRESSOR; GERM-LINE MUTATION; HUMANS; LEUKEMIA, MYELOID, ACUTE; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; NEOPLASMS; POLYCOMB-GROUP PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84921999404     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-13-0596     Document Type: Review

References (29)

1. Huynh KD, Fischle W, Verdin E, Bardwell VJ. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev 2000;14:1810-23.
2. Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol 2006; 26:6880-9.
3. Sanchez C, Sanchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 2007;6: 820-34.
4. Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, et al. KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife 2012;1:e00205.
5. Simon JA, Kingston RE. Mechanisms of polycomb gene silencing: knowns and unknowns. Nature Rev 2009;10:697-708.
6. Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, et al. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell 2012;45:344-56.
7. Wu X, Johansen JV, Helin K. Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell 2013;49:1134-46.
8. Lagarou A, Mohd-Sarip A, Moshkin YM, Chalkley GE, Bezstarosti K, Demmers JA, et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev 2008;22:2799-810.
9. Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, Kouzarides T. Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 2010;143:470-84.
10. Wu X, Gong Y, Yue J, Qiang B, Yuan J, Peng X. Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Res 2008;36:3590-9.
11. Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, et al. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 2012; 119:4152-61.
12. He J, Kallin EM, Tsukada Y, Zhang Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol 2008;15:1169-75.
13. He J, Nguyen AT, Zhang Y. KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood 2011;117:3869-80.
14. Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, et al. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol 2009;11:1002-9.
15. Junco SE, Wang R, Gaipa JC, Taylor AB, Schirf V, Gearhart MD, et al. Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. Structure 2013;21:665-71.
16. Ng D, Thakker N, Corcoran CM, Donnai D, Perveen R, Schneider A, et al. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Nat Genet 2004;36:411-6.
17. Hilton E, Johnston J, Whalen S, Okamoto N, Hatsukawa Y, Nishio J, et al. BCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects. Eur J Hum Genet 2009;17:1325-35.
18. Wamstad JA, Corcoran CM, Keating AM, Bardwell VJ. Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development. PLoS ONE 2008;3:e2814.
19. Yamamoto Y, Tsuzuki S, Tsuzuki M, Handa K, Inaguma Y, Emi N. BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. Blood 2010;116:4274-83.
20. Grossmann V, Tiacci E, Holmes AB, Kohlmann A, Martelli MP, Kern W, et al. Whole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 2011;118:6153-63.
21. Damm F, Chesnais V, Nagata Y, Yoshida K, Scourzic L, Okuno Y, et al. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood 2013;122:3169-77.
22. Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, et al. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 2012;481:329-34.
23. Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 2012;488:106-10.
24. Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, et al. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem 2007;282:15248-57.
25. Li M, Collins R, Jiao Y, Ouillette P, Bixby D, Erba H, et al. Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia. Blood 2011;118:5914-7.
26. Pierron G, Tirode F, Lucchesi C, Reynaud S, Ballet S, Cohen-Gogo S, et al. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion. Nat Genet 2012;44:461-6.
27. Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, et al. High-resolution characterization of a hepatocellular carcinoma genome. Nat Genet 2011;43:464-9.
28. Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, et al. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell 2006;9:175-87.
29. Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, et al. MEF promotes stemness in the pathogenesis of gliomas. Cell Stem Cell 2012;11:836-44.