The effect of intravenous tranexamic acid on hemoglobin and hematocrit levels after vaginal delivery: A randomized controlled trial

Iranian Journal of Obstetrics, Gynecology and Infertility

Volumn 16, Issue 60, 2013, Pages 1-8

  Mirghafourvand, Mojgan ^a   Alizadeh Charandabi, Sakineh Mohamad ^a   Abasalizadeh, Fatemeh ^a   Shirdel, Mina ^a  

^a NONE

Author keywords

Anemia; Delivery Obstetric; Hematocrit; Hemoglobins; Tranexamic acid

Indexed keywords

OXYTOCIN; PLACEBO; TRANEXAMIC ACID;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MATERNAL WELFARE; POSTPARTUM HEMORRHAGE; PREGNANT WOMAN; PUERPERIUM; RANDOMIZED CONTROLLED TRIAL; TRIPLE BLIND PROCEDURE; VAGINAL DELIVERY;

EID: 84921997756     PISSN: 16802993     EISSN: 20082363     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Milman N. Postpartum anemia: definition, prevalence, causes, and consequences. Ann Hematol 2011 Nov;90(11):1247-53.
2. Breymann C, Krafft A. Treatment of iron deficiency anemia in pregnancy and postpartum. Transfus Altern Transfus Med 2012;12(3-4):135-42.
3. Corwin EJ, Arbour M. Postpartum fatigue and evidence-based interventions. MCN Am J Matern Child Nurs 2007 Jul-ug;32(4):215-20.
4. World Health Organization, Geneva. Iron deficiency anemia;Prevention and Control; A guide for programme managers. United Nations Children's Fund UNU 2001. Available at: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en/index.html.
5. Tsu VD, Langer A, Aldrich T. Postpartum hemorrhage in developing countries: is the public health community using the right tools? Int J Gynaecol Obstet 2004 Jun;85 Sppl 1:S42-51. Review.
6. Novikova N, Hofmeyr GJ. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2010 Jul 7;(7):CD007872.
7. Ferrer P, Roberts I, Sydenham E, Blackhall K, Shakur H. Anti-fibrinolytic agents in post partum haemorrhage: a systematic review. BMC Pregnancy Childbirth 2009 Jul 15;9:29.
8. World Health Organization. WHO recommendations for the prevention and treatment of postpartum haemorrhage 2012. Available at: http://ww.who.int/iris/bitstream/ 10665/75411/9789241548502_eng.pdf. Accessed 2012.
9. Kaewpradub P, Apipan B, Rummasak D. Does tranexamic acid in an irrigating fluid reduce intraoperative blood loss in orthognathic surgery? A double-blind, randomized clinical trial. J Oral Maxillofac Surg 2011 Jun;69(6):e186-9.
10. Imai N, Dohmae Y, Suda K, Miyasaka D, Ito T, Endo N. Tranexamic acid for reduction of blood loss during total hip arthroplasty. J Arthroplasty 2012 Dec;27(10):1838-43.
11. Williams-Johnson JA, McDonald AH, Strachan GG, Williams EW. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) A randomised, placebo-controlled trial. West Indian Med J 2010 Dec;59(6):612-24.
12. Roberts I, Ker K. Tranexamic acid for postpartum bleeding. Int J Gynaecol Obstet 2011 Dec;115(3):220-1.
13. Beigi A, Tabarestani H, Moini A, Zarrinkoub F, Kazempour M. [Sublingual misoprostol versus intravenous oxytocin in the management of postpartum hemorrhage] [Article in Persian]. J Tehran Univ Med Sci 2009;67(8):556-61
14. Gungorduk K, Yildirim G, Asicioglu O, Gungorduk OC, Sudolmus S, Ark C. Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study. Am J Perinatol 2011 Mar;28(3):233-40.
15. Movafegh A, Eslamian L, Dorabadi A. Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. Int J Gynaecol Obstet 2011 Dec;115(3):224-6.
16. Senturk MB, Cakmak Y, Yildiz G, Yildiz P. Tranexamic acid for cesarean section: a double-blind, placebo-controlled, randomized clinical trial. Arch Gynecol Obstet 2013 Apr;287(4):641-5
17. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br 2001 Jul;83(5):702-5.
18. Shakur H, Elbourne D, Gulmezoglu M, Alfirevic Z, Ronsmans C, Allen E, et al. The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials 2010 Apr 16;11:40.
19. Sekhavat L, Tabatabaii A, Dalili M, Farajkhoda T, Tafti AD. Efficacy of tranexamic acid in reducing blood loss after cesarean section. J Matern Fetal Neonatal Med 2009 Jan;22(1):72-5.
20. Gai MY, Wu LF, Su QF, Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 2004 Feb 10;112(2):154-7.