Clinical validation of an epigenetic assay to predict negative histopathological results in repeat prostate biopsies

Journal of Urology

Volumn 192, Issue 4, 2014, Pages 1081-1087

  Partin, Alan W ^a   Van Neste, Leander ^b,e   Klein, Eric A ^c   Marks, Leonard S ^d   Gee, Jason R ^f   Troyer, Dean A ^g   Rieger Christ, Kimberly ^f   Jones, J Stephen ^c   Magi Galluzzi, Cristina ^c   Mangold, Leslie A ^a   Trock, Bruce J ^a   Lance, Raymond S ^g   Bigley, Joseph W ^e   Van Criekinge, Wim ^e,h   Epstein, Jonathan I ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MDxHealth   (Belgium)

^f LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^g EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^h GHENT UNIVERSITY   (Belgium)

Author keywords

biopsy; epigenomics; methylation; prostate; prostatic neoplasms

Indexed keywords

APC PROTEIN; GLUTATHIONE TRANSFERASE P1; PROSTATE SPECIFIC ANTIGEN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; DNA; GSTP1 PROTEIN, HUMAN; RASSF1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIGITAL RECTAL EXAMINATION; DNA METHYLATION; EPIGENETICS; FALSE POSITIVE RESULT; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; RACE DIFFERENCE; REPEAT PROCEDURE; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; UNITED STATES; VALIDATION STUDY; BIOPSY; BIOSYNTHESIS; CLINICAL TRIAL; FOLLOW UP; GENETIC EPIGENESIS; GENETICS; METABOLISM; PATHOLOGY; PROCEDURES; PROGNOSIS; PROSTATE; PROSTATE TUMOR; TUMOR SUPPRESSOR GENE; UNNECESSARY PROCEDURE; UTILIZATION;

BIOPSY; DNA METHYLATION; DNA, NEOPLASM; EPIGENESIS, GENETIC; EPIGENOMICS; FOLLOW-UP STUDIES; GENES, APC; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MALE; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSTATE; PROSTATIC NEOPLASMS; TUMOR SUPPRESSOR PROTEINS; UNNECESSARY PROCEDURES;

EID: 84921965151     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2014.04.013     Document Type: Article

References (26)

1. A.R. Zlotta, and R.K. Nam To biopsy or not to biopsy - thou shall think twice Eur Urol 61 2012 1115
2. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2013 CA Cancer J Clin 63 2013 11
3. P.F. Pinsky, E.D. Crawford, and B.S. Kramer Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trial BJU Int 99 2007 775
4. B. Djavan, A. Zlotta, and M. Remzi Optimal predictors of prostate cancer on repeat prostate biopsy: a prospective study of 1,051 men J Urol 163 2000 1144
5. I.M. Thompson, C.M. Tangen, and D.P. Ankerst The performance of prostate specific antigen for predicting prostate cancer is maintained after a prior negative prostate biopsy J Urol 180 2008 544
6. D.A. Troyer, M.S. Lucia, and A.P. de Bruïne Prostate cancer detected by methylated gene markers in histopathologically cancer-negative tissues from men with subsequent positive biopsies Cancer Epidemiol Biomarkers Prev 18 2009 2717
7. K.E. Schuebel, W. Chen, and L. Cope Comparing the DNA hypermethylome with gene mutations in human colorectal cancer PLoS Genet 3 2007 1709
8. J. Mehrotra, S. Varde, and H. Wang Quantitative, spatial resolution of the epigenetic field effect in prostate cancer Prostate 68 2008 152
9. S. Loeb, H.B. Carter, and S.I. Berndt Complications after prostate biopsy: data from SEER-Medicare J Urol 186 2011 1830
10. W.H. Lee, R.A. Morton, and J.I. Epstein Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis Proc Natl Acad Sci U S A 91 1994 11733
11. L. Van Neste, J.G. Herman, and G. Otto The epigenetic promise for prostate cancer diagnosis Prostate 72 2012 1248
12. B.J. Trock, M.J. Brotzman, and L.A. Mangold Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies BJU Int 110 2012 56
13. M. Kanehisa, S. Goto, and M. Furumichi KEGG for representation and analysis of molecular networks involving diseases and drugs Nucleic Acids Res 38 2010 D355
14. V.L. Costa, R. Henrique, and F.R. Ribeiro Epigenetic regulation of Wnt signaling pathway in urological cancer Epigenetics 5 2010 343
15. R. Dammann, U. Schagdarsurengin, and M. Strunnikova Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis Histol Histopathol 18 2003 665
16. G.D. Stewart, L. Van Neste, and P. Delvenne Clinical utility of an epigenetic assay to detect occult prostate cancer in histopathologically negative biopsies: results of the MATLOC study J Urol 189 2013 1110
17. K. Eichler, S. Hempel, and J. Wilby Diagnostic value of systematic biopsy methods in the investigation of prostate cancer: a systematic review J Urol 175 2006 1605
18. D.M. Steinberg, J. Fine, and R. Chappell Sample size for positive and negative predictive value in diagnostic research using case-control designs Biostatistics 10 2009 94
19. P.A. Mancuso, C. Chabert, and P. Chin Prostate cancer detection in men with an initial diagnosis of atypical small acinar proliferation BJU Int 99 2007 49
20. M.M. Amin, S. Jeyaganth, and N. Fahmy Subsequent prostate cancer detection in patients with prostatic intraepithelial neoplasia or atypical small acinar proliferation Can Urol Assoc J 1 2007 245
21. L. Van Neste, J. Bigley, and A. Toll A tissue biopsy-based epigenetic multiplex PCR assay for prostate cancer detection BMC Urol 12 2012 16
22. M. Truong, B. Yang, and A. Livermore Using the epigenetic field defect to detect prostate cancer in biopsy negative patients J Urol 189 2013 2335
23. F.H. Schröder, J. Hugosson, and M.J. Roobol Screening and prostate-cancer mortality in a randomized European study N Engl J Med 360 2009 1320
24. United States Preventive Services Task Force Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement Ann Intern Med 149 2008 185
25. M. Toyota, N. Ahuja, and M. Ohe-Toyota CpG island methylator phenotype in colorectal cancer Proc Natl Acad Sci U S A 96 1999 8681
26. N.A. Damaschke, B. Yang, and S. Bhusari Epigenetic susceptibility factors for prostate cancer with aging Prostate 73 2013 1721