An absorbing sense of sweetness

Diabetes

Volumn 64, Issue 2, 2015, Pages 338-340

  Gribble, Fiona M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 1; GLUCOKINASE; GLUCOSE; INCRETIN; INSULIN; PHLORIZIN; SODIUM GLUCOSE COTRANSPORTER 1; SWEETENING AGENT;

GLUCOSE ABSORPTION; HUMAN; INSULIN RELEASE; NONHUMAN; NOTE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN SECRETION; SWEETNESS; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; MALE; METABOLISM; SMALL INTESTINE;

ANIMALS; GENE EXPRESSION REGULATION; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; INTESTINE, SMALL; MALE;

EID: 84921918795     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1477     Document Type: Note

References (14)

1. Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am J Med 2011;124(Suppl.):S3-S18
2. Kuhre RE, Frost CR, Svendsen B, Holst JJ. Molecular mechanisms of glucose-stimulated GLP-1 secretion from perfused rat small intestine. Diabetes 2015;64:370-382
3. Ashcroft FM, Rorsman P. K (ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol 2013;9:660-669
4. El-Ouaghlidi A, Rehring E, Holst JJ, et al. The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion. J Clin Endocrinol Metab 2007;92:4165-4171
5. Murphy R, Tura A, Clark PM, Holst JJ, Mari A, Hattersley AT. Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor. Diabetologia 2009;52:154-159
6. Pearson ER, Flechtner I, Njølstad PR, et al; Neonatal Diabetes International Collaborative Group. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006;355:467-477
7. Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 2007;104:15069-15074
8. Gribble FM, Williams L, Simpson AK, Reimann F. A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes 2003;52:1147-1154
9. Gorboulev V, Schürmann A, Vallon V, et al. Na (+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 2012;61:187-196
10. Ma J, Bellon M, Wishart JM, et al. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol Gastrointest Liver Physiol 2009;296:G735-G739
11. Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, Gribble FM. Glucose sensing in L cells: a primary cell study. Cell Metab 2008;8:532-539
12. Zambrowicz B, Ogbaa I, Frazier K, et al. Effects of LX4211, a dual sodiumdependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects. Clin Ther 2013;35:116221173.e8
13. Powell DR, Smith M, Greer J, et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1) - mediated absorption of intestinal glucose. J Pharmacol Exp Ther 2013;345:250-259
14. Jørgensen NB, Jacobsen SH, Dirksen C, et al. Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with type 2 diabetes and normal glucose tolerance. AmJ Physiol EndocrinolMetab 2012;303:E122-E131