Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes

Diabetes Care

Volumn 38, Issue 2, 2015, Pages 329-332

  Kemppainen, Kaisa M ^a   Ardissone, Alexandria N ^a   Davis Richardson, Austin G ^a   Fagen, Jennie R ^a   Gano, Kelsey A ^a   León Novelo, Luis G ^b   Vehik, Kendra ^c   Casella, George ^d   Simell, Olli ^e   Ziegler, Anette G ^f   Rewers, Marian J ^g   Lernmark, Åke ^h   Hagopian, William ⁱ   She, Jin Xiong ^j   Krischer, Jeffrey P ^c   Akolkar, Beena ^k   Schatz, Desmond A ^l   Atkinson, Mark A ^l   Triplett, Eric W ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF LOUISIANA AT LAFAYETTE   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d University of Turku ^*  (United States)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g UNIVERSITY OF COLORADO DENVER   (United States)

^h LUND UNIVERSITY   (Sweden)

ⁱ PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^j MEDICAL COLLEGE OF GEORGIA   (United States)

^k NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^l UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; RNA 16S;

AKKERMANSIA; ARTICLE; BACTEROIDES; BIFIDOBACTERIUM; CLOSTRIDIUM; CONTROLLED STUDY; FAECALIBACTERIUM; FINLAND; GENOTYPE; GEOGRAPHY; GERMANY; HIGH RISK INFANT; HIGH THROUGHPUT SEQUENCING; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE FLORA; MICROBIAL COLONIZATION; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; OBSERVATIONAL STUDY; PILOT STUDY; POPULATION ABUNDANCE; PROSPECTIVE STUDY; STREPTOCOCCUS; SWEDEN; UNITED STATES; VEILLONELLA; CLINICAL TRIAL; DEMOGRAPHY; DIABETES MELLITUS, TYPE 1; FECES; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INTESTINE; ISOLATION AND PURIFICATION; MALE; METABOLISM; MICROBIOLOGY; MICROFLORA; MULTICENTER STUDY; PHYSIOLOGY; PRESCHOOL CHILD; RISK FACTOR;

CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FECES; FEMALE; FINLAND; GERMANY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; INFANT; INTESTINES; MALE; MICROBIOTA; PILOT PROJECTS; RESIDENCE CHARACTERISTICS; RISK FACTORS; RNA, RIBOSOMAL, 16S; SWEDEN; UNITED STATES;

EID: 84921900196     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-0850     Document Type: Article

References (18)

1. TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 2007;8:286-298
2. Murri M, Leiva I, Gomez-Zumaquero JM, et al. Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. BMC Med 2013;11:46
3. De Goffau MC, Luopajärvi K, Knip M, et al. Fecal microbiota composition differs between children with b-cell autoimmunity and those without. Diabetes 2013;62:1238-1244
4. Giongo A, Gano KA, Crabb DB, et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J 2011;5:82-91
5. Brown CT, Davis-Richardson AG, Giongo A, et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One 2011;6:e25792
6. Endesfelder D, Zu Castell W, Ardissone A, et al. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 2014;63:2006-2014
7. Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature 2012;486:222-227
8. Echarri PP, Graciá CM, Berruezo GR, et al. Assessment of intestinal microbiota of fullterm breast-fed infants from two different geographical locations. Early Hum Dev 2011;87:511-513
9. Fallani M, Young D, Scott J, et al.; Other Members of the INFABIO Team. Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics. J Pediatr Gastroenterol Nutr 2010;51:77-84
10. Grzéskowiak É, Grönlund MM, Beckmann C, Salminen S, Von Berg A, Isolauri E. The impact of perinatal probiotic intervention on gut microbiota: double-blind placebo-controlled trials in Finland and Germany. Anaerobe 2012;18:7-13
11. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A 2010;107:14691-14696
12. Vehik K, Fiske SW, Logan CA, et al.; TEDDY Study Group. Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY. Diabetes Metab Res Rev 2013;29:557-567
13. Roesch LF, Casella G, Simell O, et al. Influence of fecal sample storage on bacterial community diversity. Open Microbiol J 2009;3:40-46
14. Fagen JR, Giongo A, Brown CT, Davis-Richardson AG, Gano KA, Triplett EW. Characterization of the relative abundance of the citrus pathogen Ca. Liberibacter asiaticus in the microbiome of its insect vector, Diaphorina citri, using high throughput 16S rRNA sequencing. Open Microbiol J 2012;6:29-33
15. R Core Team. R: a language and environment for statistical computing [Internet], 2014. Version 3.0.0. Vienna, Austria, R Foundation for Statistical Computing. Available from http://www.R-project.org. Accessed 5 April 2013
16. Léon-Novelo L, Kemppainen KM, Ardissone A, et al.; TEDDY Study Group. Two applications of permutation tests in biostatistics. Bol Soc Mat Mex 2013;19:255-266
17. Borchers AT, Uibo R, Gershwin ME. The geoepidemiology of type 1 diabetes. Autoimmun Rev 2010;9:A355-A365
18. Scholtens PA, Oozeer R, Martin R, Amor KB, Knol J. The early settlers: intestinal microbiology in early life. Annu Rev Food Sci Technol 2012;3:425-447